Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Keisuke Shibata"'
Publikováno v:
Journal of Physical Fitness and Sports Medicine, Vol 10, Iss 4, Pp 191-198 (2021)
Work-matched high-intensity intermittent cycling training (HIICT) reportedly improves VO2max regardless of the combination of loads and cadences. However, the effect of work-matched HIICT with different combinations of loads and cadences on anaerobic
Externí odkaz:
https://doaj.org/article/f4fce3d500104a7b825dd994599d9581
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 6, Pp n/a-n/a (2021)
Abstract The anticancer agents platinum derivatives and taxanes such as paclitaxel (PCX) often cause neuropathy known as chemotherapy‐induced peripheral neuropathy with high frequency. However, the cellular and molecular mechanisms underlying such
Externí odkaz:
https://doaj.org/article/d4358e8b2ac54721847e4f4f965bd422
Autor:
Manao Kinoshita, Yuri Hirayama, Kayoko Fujishita, Keisuke Shibata, Youichi Shinozaki, Eiji Shigetomi, Akiko Takeda, Ha Pham Ngoc Le, Hideaki Hayashi, Miki Hiasa, Yoshinori Moriyama, Kazuhiro Ikenaka, Kenji F. Tanaka, Schuichi Koizumi
Publikováno v:
EBioMedicine, Vol 32, Iss , Pp 72-83 (2018)
Although psychotropic drugs act on neurons and glial cells, how glia respond, and whether glial responses are involved in therapeutic effects are poorly understood. Here, we show that fluoxetine (FLX), an anti-depressant, mediates its anti-depressive
Externí odkaz:
https://doaj.org/article/0994b8524db94945898522171ad5a080
Autor:
Youichi Shinozaki, Keisuke Shibata, Keitaro Yoshida, Eiji Shigetomi, Christian Gachet, Kazuhiro Ikenaka, Kenji F. Tanaka, Schuichi Koizumi
Publikováno v:
Cell Reports, Vol 19, Iss 6, Pp 1151-1164 (2017)
Microglia and astrocytes become reactive following traumatic brain injury (TBI). However, the coordination of this reactivity and its relation to pathophysiology are unclear. Here, we show that microglia transform astrocytes into a neuroprotective ph
Externí odkaz:
https://doaj.org/article/7887800b970d4006874b04452b89b1d0
Autor:
Satoru Kira, Mitsuharu Yoshiyama, Sachiko Tsuchiya, Eiji Shigetomi, Tatsuya Miyamoto, Hiroshi Nakagomi, Keisuke Shibata, Tsutomu Mochizuki, Masayuki Takeda, Schuichi Koizumi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The role of the P2Y6 receptor in bladder function has recently attracted a great deal of attention in lower urinary tract research. We conducted this study to determine contributions of the P2Y6 receptor in lower urinary tract function of no
Externí odkaz:
https://doaj.org/article/dd34c3d825a442119d3e79bbd1e71e90
Autor:
Akiko Miyamoto, Hiroaki Wake, Ayako Wendy Ishikawa, Kei Eto, Keisuke Shibata, Hideji Murakoshi, Schuichi Koizumi, Andrew J. Moorhouse, Yumiko Yoshimura, Junichi Nabekura
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Microglia contribute to shaping neural circuits in the developing brain. Here, the authors show that microglial contact with pyramidal neuron dendrites induces synapse formation in the developing somatosensory cortex, and ablation of microglia reduce
Externí odkaz:
https://doaj.org/article/45fff4d674a54f38b5ae086508a1e2b5
Autor:
Tatsuya Ihara, Takahiko Mitsui, Yuki Nakamura, Satoru Kira, Hiroshi Nakagomi, Norifumi Sawada, Yuri Hirayama, Keisuke Shibata, Eiji Shigetomi, Yoichi Shinozaki, Mitsuharu Yoshiyama, Karl-Erik Andersson, Atsuhito Nakao, Masayuki Takeda, Schuichi Koizumi
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0168234 (2017)
ClockΔ19/Δ19 mice is an experimental model mouse for nocturia (NOC). Using the bladder mucosa obtained from ClockΔ19/Δ19 mice, we investigated the gene expression rhythms of mechanosensory cation channels such as transient receptor potential cati
Externí odkaz:
https://doaj.org/article/922c06edd20e4109b9c00331a9d3c3cf
Publikováno v:
Sports, Vol 6, Iss 4, p 107 (2018)
The aim of this study is to clarify the effects of 3-week work-matched high-intensity intermittent cycling training (HIICT) with different cadences on the VO2max of university athletes. Eighteen university athletes performed HIICT with either 60 rpm
Externí odkaz:
https://doaj.org/article/e19df40b00634b9b9be1b642908085ad
Autor:
Fuyuko Takata, Shinya Dohgu, Atsushi Yamauchi, Junichi Matsumoto, Takashi Machida, Kayoko Fujishita, Keisuke Shibata, Youichi Shinozaki, Kaoru Sato, Yasufumi Kataoka, Schuichi Koizumi
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55166 (2013)
The blood-brain barrier (BBB) restricts the entry of circulating drugs and xenobiotics into the brain, and thus its permeability to substances is a critical factor that determines their central effects. The infant brain is vulnerable to neurotoxic su
Externí odkaz:
https://doaj.org/article/8610a0338b9b489a8ba4df5efe82da35
Autor:
Yusuke Noguchi, Youichi Shinozaki, Kayoko Fujishita, Keisuke Shibata, Yoshio Imura, Yosuke Morizawa, Christian Gachet, Schuichi Koizumi
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57898 (2013)
Methylmercury (MeHg) is a well known environmental pollutant that induces serious neuronal damage. Although MeHg readily crosses the blood-brain barrier, and should affect both neurons and glial cells, how it affects glia or neuron-to-glia interactio
Externí odkaz:
https://doaj.org/article/6c1336aba9b6489087676e81af51b912