Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Keisuke S. Iwamoto"'
Autor:
Prabhat K. Purbey, Joowon Seo, Manash K. Paul, Keisuke S. Iwamoto, Allison E. Daly, An-Chieh Feng, Ameya S. Champhekar, Justin Langerman, Katie M. Campbell, Dörthe Schaue, William H. McBride, Steven M. Dubinett, Antoni Ribas, Stephen T. Smale, Philip O. Scumpia
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114289- (2024)
Summary: Type I interferon (IFN-I) and IFN-γ foster antitumor immunity by facilitating T cell responses. Paradoxically, IFNs may promote T cell exhaustion by activating immune checkpoints. The downstream regulators of these disparate responses are i
Externí odkaz:
https://doaj.org/article/1aacdb1bc8d04f2aac55bcac0e7d97b6
Autor:
Dörthe Schaue, Ewa D. Micewicz, Josephine A. Ratikan, Keisuke S. Iwamoto, Erina Vlashi, J. Tyson McDonald, William H. McBride
Publikováno v:
Antioxidants, Vol 11, Iss 9, p 1649 (2022)
Nuclear factor erythroid 2-related factor 2 (NRF2) is recognized as a master transcription factor that regulates expression of numerous detoxifying and antioxidant cytoprotective genes. In fact, models of NRF2 deficiency indicate roles not only in re
Externí odkaz:
https://doaj.org/article/d93c14d74c3a4a43a4f52aa740921de6
Autor:
Ewa D. Micewicz, Robert D. Damoiseaux, Gang Deng, Adrian Gomez, Keisuke S. Iwamoto, Michael E. Jung, Christine Nguyen, Andrew J. Norris, Josephine A. Ratikan, Piotr Ruchala, James W. Sayre, Dörthe Schaue, Julian P. Whitelegge, William H. McBride
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
We previously reported several vignettes on types and classes of drugs able to mitigate acute and, in at least one case, late radiation syndromes in mice. Most of these had emerged from high throughput screening (HTS) of bioactive and chemical drug l
Externí odkaz:
https://doaj.org/article/51771cf263924ecca3296a531a0d3deb
Autor:
Keisuke S. Iwamoto, PhD, Robert E. Sandstrom, MD, Mark Bryan, EdM, Yue Liu, PhD, S. Robin Elgart, PhD, Ke Sheng, PhD, Michael L. Steinberg, MD, William H. McBride, DSc, Daniel A. Low, PhD
Publikováno v:
Advances in Radiation Oncology, Vol 6, Iss 3, Pp 100645- (2021)
Purpose: The clinical efficacy of radiation therapy is mechanistically linked to ionization-induced free radicals that cause cell and tissue injury through direct and indirect mechanisms. Free radical reaction dynamics are influenced by many factors
Externí odkaz:
https://doaj.org/article/09bd2ef75e0c48eaba3967ae6c9af553
Autor:
Chenyang Wang, MD, PhD, Amar U. Kishan, MD, James B. Yu, MD, MHS, Ann Raldow, MD, MPH, Christopher R. King, MD, PhD, Keisuke S. Iwamoto, PhD, Fang-I. Chu, PhD, Michael L. Steinberg, MD, Patrick A. Kupelian, MD
Publikováno v:
Advances in Radiation Oncology, Vol 4, Iss 4, Pp 738-747 (2019)
Purpose: Second malignancies (SMs) after radiation therapy are rare but serious sequelae of treatment. This study investigates whether radiation therapy use is associated with changes in baseline SM risk. Methods and Materials: We extracted all patie
Externí odkaz:
https://doaj.org/article/f7fd2e1cc5dd4ee88af217163b86465e
Autor:
William H. McBride, Richard A. Gatti, Brendan D. Price, James W. Sayre, Keisuke S. Iwamoto, Robert Damoiseaux, Kelly Pettijohn, Ewa Micewicz, Yingli Sun, J. Tyson McDonald, Andrew J. Norris, Julianne M. Pollard, Kwanghee Kim
Supplementary Data from High-Throughput Screening Identifies Two Classes of Antibiotics as Radioprotectors: Tetracyclines and Fluoroquinolones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0960677a01c4e45db8e4978dacbb2369
https://doi.org/10.1158/1078-0432.22440594
https://doi.org/10.1158/1078-0432.22440594
Autor:
William H. McBride, Richard A. Gatti, Brendan D. Price, James W. Sayre, Keisuke S. Iwamoto, Robert Damoiseaux, Kelly Pettijohn, Ewa Micewicz, Yingli Sun, J. Tyson McDonald, Andrew J. Norris, Julianne M. Pollard, Kwanghee Kim
Purpose: Discovery of agents that protect or mitigate normal tissue from radiation injury during radiotherapy, accidents, or terrorist attacks is of importance. Specifically, bone marrow insufficiency, with possible infection due to immunosuppression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05be5f2b77aa2c0354fa03b35a4ceefa
https://doi.org/10.1158/1078-0432.c.6517896.v1
https://doi.org/10.1158/1078-0432.c.6517896.v1
Autor:
Prabhat Kumar Purbey, Manash K. Paul, Keisuke S. Iwamoto, Allison Daly, Joowon Seo, Ameya S. Champhekar, Katie Campbell, Dorthe Schaue, William H. McBride, Steven M. Dubinett, Antoni Ribas, Stephen T. Smale, Philip O. Scumpia
Publikováno v:
Cancer Research. 83:2325-2325
Interferons (IFNs), including IFN-α/β and IFN-γ, are multifaceted cytokines critical for antitumor immunity but contribute to T cell exhaustion through immune checkpoints. Recently, tumor cell expression of IRF1 was shown to enhance antitumor immu
Publikováno v:
NATO Science for Peace and Security Series A: Chemistry and Biology ISBN: 9789402421002
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::713997f4feee852acf822956d95298be
https://doi.org/10.1007/978-94-024-2101-9_6
https://doi.org/10.1007/978-94-024-2101-9_6
Publikováno v:
Health Physics. 118:209-214
The University of California possesses a large number of Cs irradiators that are used in a wide variety of medical and research applications. The university president made a system-wide decision to reduce the potential threat of malevolent use of Cs