Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Keisuke Matsuhara"'
Autor:
Akihiro Ito, Koichi Narita, Singo Dan, Minoru Yoshida, Yui Akiyama, Tadashi Katoh, Jun Itoh, Takao Yamori, Keisuke Matsuhara
Publikováno v:
European journal of medicinal chemistry. 121
Novel C4- and C7-modified FK228 analogues were efficiently synthesized in a highly convergent and unified manner. This synthesis features the amide condensation of glycine-d-cysteine-containing segments with d-valine-containing segments for the direc
Autor:
Toshiya Takizawa, Keisuke Matsuhara, Hideki Abe, Kyosuke Kudo, Takamasa Oguchi, Takuya Kikuchi, Koichi Narita, Tadashi Katoh, Minoru Yoshida, Kazuhiro Watanabe, Takao Yamori
Publikováno v:
Chemistry - A European Journal. 15:11174-11186
The bicyclic depsipeptide histone deacetylase (HDAC) inhibitors spiruchostatins A and B, 5''-epi-spiruchostatin B and FK228 were efficiently synthesized in a convergent and unified manner. The synthetic method involved the following crucial steps: i)