Výsledky vyhledávání - "Keisuke Kohga"

Data from Anticancer Chemotherapy Inhibits MHC Class I–Related Chain A Ectodomain Shedding by Downregulating ADAM10 Expression in Hepatocellular Carcinoma

Autor: Norio Hayashi, Naoki Hiramatsu, Tatsuya Kanto, Kazuyoshi Ohkawa, Hisashi Ishida, Takuya Miyagi, Tomohide Tatsumi, Tetsuo Takehara, Keisuke Kohga

MHC class I–related chain A (MICA) is a ligand for the NKG2D-activating immunoreceptor that mediates activation of natural killer (NK) cells. The ectodomain of MICA is shed from tumor cells, which may be an important means of evading antitumor immu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::778af4d70493cff9589e220b2eab8c5c
https://doi.org/10.1158/0008-5472.c.6499886.v1

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The combination therapy of α-galactosylceramide and 5-fluorouracil showed antitumor effect synergistically against liver tumor in mice

Autor: Hiroshi Aketa, Naoki Hiramatsu, Tatsuya Kanto, Tetsuo Takehara, Hinako Tsunematsu, Takuya Miyagi, Ryotaro Sakamori, Hayato Hikita, Tomohide Tatsumi, Satoshi Aono, Keisuke Kohga, Takatoshi Nawa, Norio Hayashi, Satoshi Shimizu, Atsushi Hosui, Minoru Shigekawa, Takahiro Kodama

Publikováno v: International Journal of Cancer. 133:1126-1134

α-Galactosylceramide (α-GalCer) has been reported to be therapeutic against metastatic liver tumors in mice. However, little is known regarding the efficacy of combined chemo-immunotherapy using α-GalCer and anticancer drugs. In this study, we eva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f59d57544bc2b8ef923da967104689b6
https://doi.org/10.1002/ijc.28118

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Altered interferon-α-signaling in natural killer cells from patients with chronic hepatitis C virus infection

Autor: Kumiko Nishio, Norio Hayashi, Satoshi Shimizu, Keisuke Kohga, Wei Li, Tomohide Tatsumi, Tetsuo Takehara, Tatsuya Kanto, Takuya Miyagi, Naoki Hiramatsu

Publikováno v: Journal of Hepatology. 53:424-430

Background & Aims Natural killer (NK) cells play an important role in the immune response against virus infection. Interferon (IFN)-α, an essential component in therapy against hepatitis C virus (HCV) infection, regulates NK cell function. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99dc5b3745c7b6ba7a7233a89377df3f
https://doi.org/10.1016/j.jhep.2010.03.018

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Fatal exacerbation of type B chronic hepatitis triggered by changes in relaxed circular viral DNA synthesis and virion secretion

Autor: Akio Uemura, Tetsuo Takehara, Hisashi Ishida, Akira Sasakawa, Shinjiro Yamaguchi, Hayato Hikita, Tomohide Tatsumi, Takahiro Kodama, Norio Hayashi, Satoshi Shimizu, Wei Li, Kazuhiro Katayama, Ryotaro Sakamori, Masashi Yamamoto, Takuya Miyagi, Atsushi Hosui, Kazuyoshi Ohkawa, Keisuke Kohga

Publikováno v: Biochemical and Biophysical Research Communications. 394:87-93

Virological features of fulminant liver disease-causing hepatitis B virus (HBV) have not been fully elucidated. We studied longitudinally the viruses obtained before and after fulminant liver disease in a patient with chronic HBV infection showing fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da28063d16becceef012756059ce2547
https://doi.org/10.1016/j.bbrc.2010.02.114

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Supportive Role Played by Precore and PreS2 Genomic Changes in the Establishment of Lamivudine‐Resistant Hepatitis B Virus

Autor: Norio Hayashi, Matsuo Deguchi, Tetsuo Takehara, Akio Uemura, Akira Sasakawa, Ryotaro Sakamori, Hisashi Ishida, Shinjiro Yamaguchi, Tomohide Tatsumi, Michio Kato, Takuya Miyagi, Keisuke Kohga, Masanori Kagita, Kazuyoshi Ohkawa, Hayato Hikita

Publikováno v: The Journal of Infectious Diseases. 198:1150-1158

Background. Hepatitis B virus (HBV) establishes lamivudine resistance via the resistance-causative rtM204V/I mutation and the replication-compensatory rtL180M mutation. However, both lamivudine-resistant viruses with and those without rtL180M can exi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7fd4ee8d3905d0da8f4ae348bf014f8
https://doi.org/10.1086/591941

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Serum levels of soluble major histocompatibility complex (MHC) class I-related chain A in patients with chronic liver diseases and changes during transcatheter arterial embolization for hepatocellular carcinoma

Autor: Kazuyoshi Ohkawa, Norio Hayashi, Keisuke Kohga, Tsutomu Kasugai, Kazuhiro Katayama, Tetsuo Takehara, Michio Kato, Tatsuya Kanto, Takuya Miyagi, Tomohide Tatsumi, Naoki Hiramatsu

Publikováno v: Cancer Science. 99:1643-1649

Soluble forms of major histocompatibility complex (MHC) class I-related chain A and B (MICA/B) are increased in the sera of patients with malignancy and impair the antitumor immune response by downregulating expression of their cognate immunoreceptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feffb3e483a94aa1133d614fe5daa08b
https://doi.org/10.1111/j.1349-7006.2008.00859.x

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Dendritic cell-based vaccines suppress metastatic liver tumor via activation of local innate and acquired immunity

Autor: Akio Uemura, Akira Sasakawa, Tetsuo Takehara, Kazuyoshi Ohkawa, Shinjiro Yamaguchi, Hayato Hikita, Tomohide Tatsumi, Norio Hayashi, Keisuke Kohga, Ryotaro Sakamori

Publikováno v: Cancer Immunology, Immunotherapy. 57:1861-1869

Dendritic cell (DC)-based vaccines have been applied clinically in the setting of cancer, but tumor-associated antigens (TAAs) have not yet been enough identified in various cancers. In this study, we investigated whether preventive vaccination with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d063f770e1aa3f2f990edc7575ab7384
https://doi.org/10.1007/s00262-008-0514-5

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