Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Keisuke, Nagatsuma"'
Autor:
Xian-Yang Qin, Mitsuko Hara, Erik Arner, Yoshikuni Kawaguchi, Ikuyo Inoue, Hideki Tatsukawa, Yutaka Furutani, Keisuke Nagatsuma, Tomokazu Matsuura, Feifei Wei, Jun Kikuchi, Hideko Sone, Carsten Daub, Hideya Kawaji, Timo Lassmann, Masayoshi Itoh, Harukazu Suzuki, Piero Carninci, Yoshihide Hayashizaki, Norihiro Kokudo, Alistair R.R. Forrest, Soichi Kojima
Publikováno v:
EBioMedicine, Vol 24, Iss C, Pp 257-266 (2017)
The acute phase protein orosomucoid-1 (Orm1) is mainly expressed by hepatocytes (HPCs) under stress conditions. However, its specific function is not fully understood. Here, we report a role of Orm1 as an executer of HPC proliferation. Increases in s
Externí odkaz:
https://doaj.org/article/2d67145a46cb4efdaebcf3fdbe40b328
Autor:
Jonghyuk Park, Takahiro Masaki, Yoshihiro Mezaki, Hiroshi Yokoyama, Mariko Nakamura, Haruka Maehashi, Takahiko J Fujimi, Sabine S Gouraud, Keisuke Nagatsuma, Madoka Nakagomi, Naofumi Kimura, Tomokazu Matsuura
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189346 (2017)
We developed a bio-artificial liver (BAL) using a radial-flow bioreactor and rescued mini-pig models with lethal acute liver failure (ALF). The point of the rescue is the recovery from hepatic encephalopathy (HE). HE on ALF has sometimes resulted in
Externí odkaz:
https://doaj.org/article/b6537d1327ff4c668cb7a53d8a4d32d7
Autor:
Akihito Tsubota, Kaoru Mogushi, Hideki Aizaki, Ken Miyaguchi, Keisuke Nagatsuma, Hiroshi Matsudaira, Tatsuya Kushida, Tomomi Furihata, Hiroshi Tanaka, Tomokazu Matsuura
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97078 (2014)
Despite advances in chronic hepatitis C treatment, a proportion of patients respond poorly to treatment. This study aimed to explore hepatic mRNA and microRNA signatures involved in hepatitis C treatment resistance. Global hepatic mRNA and microRNA e
Externí odkaz:
https://doaj.org/article/3db261d955cf4f138548473a638d8423
Autor:
Shigeo Koido, Sadamu Homma, Masato Okamoto, Yoshihisa Namiki, Kazuki Takakura, Akitaka Takahara, Shunichi Odahara, Shintaro Tsukinaga, Toyokazu Yukawa, Jimi Mitobe, Hiroshi Matsudaira, Keisuke Nagatsuma, Kan Uchiyama, Mikio Kajihara, Seiji Arihiro, Hiroo Imazu, Hiroshi Arakawa, Shin Kan, Hideo Komita, Masaki Ito, Toshifumi Ohkusa, Jianlin Gong, Hisao Tajiri
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59280 (2013)
Induction of antitumor immunity by dendritic cell (DC)-tumor fusion cells (DC/tumor) can be modulated by their activation status. In this study, to address optimal status of DC/tumor to induce efficient antigen-specific cytotoxic T lymphocytes (CTLs)
Externí odkaz:
https://doaj.org/article/f9bca064f86b47ee88a708ebda059b2e
Autor:
Shigeo Koido, Sadamu Homma, Masato Okamoto, Yoshihisa Namiki, Kazuki Takakura, Akitaka Takahara, Shunichi Odahara, Shintaro Tsukinaga, Toyokazu Yukawa, Jimi Mitobe, Hiroshi Matsudaira, Keisuke Nagatsuma, Mikio Kajihara, Kan Uchiyama, Seiji Arihiro, Hiroo Imazu, Hiroshi Arakawa, Shin Kan, Kazumi Hayashi, Hideo Komita, Yuko Kamata, Masaki Ito, Eiichi Hara, Toshifumi Ohkusa, Jianlin Gong, Hisao Tajiri
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63498 (2013)
The therapeutic efficacy of fusion cell (FC)-based cancer vaccine generated with whole tumor cells and dendritic cells (DCs) requires the improved immunogenicity of both cells. Treatment of whole tumor cells with ethanol resulted in blockade of immun
Externí odkaz:
https://doaj.org/article/52c8cf7b36164d51a25975fae2501569
Autor:
Shigeo Koido, Sadamu Homma, Akitaka Takahara, Yoshihisa Namiki, Shintaro Tsukinaga, Jimi Mitobe, Shunichi Odahara, Toyokazu Yukawa, Hiroshi Matsudaira, Keisuke Nagatsuma, Kan Uchiyama, Kenichi Satoh, Masaki Ito, Hideo Komita, Hiroshi Arakawa, Toshifumi Ohkusa, Jianlin Gong, Hisao Tajiri
Publikováno v:
Clinical and Developmental Immunology, Vol 2011 (2011)
Pancreatic cancer is a highly aggressive and notoriously difficult to treat. As the vast majority of patients are diagnosed at advanced stage of the disease, only a small population is curative by surgical resection. Although gemcitabine-based chemot
Externí odkaz:
https://doaj.org/article/d18530e749e64929869e2ef3873f94f6
Autor:
Jonghyuk Park, Hiroshi Yokoyama, Takahiro Masaki, Haruki Senoo, Tomokazu Matsuura, Mariko Nakamura, Keisuke Nagatsuma, Rune Blomhoff, Yoshihiro Mezaki
Publikováno v:
Polar Biology. 41:805-815
Vitamin A is a fat-soluble vitamin required for many physiological functions. It is known that polar bears (Ursus maritimus) store a large amount of vitamin A within hepatic stellate cells (HSCs). However, the molecular mechanisms for high-capacity s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a521abf6923d26cd8435a0d4a90ac830
https://doi.org/10.1007/s00300-017-2241-x
https://doi.org/10.1007/s00300-017-2241-x
Autor:
Carsten O. Daub, Hideya Kawaji, Yoshikuni Kawaguchi, Masayoshi Itoh, Alistair R. R. Forrest, Norihiro Kokudo, Mitsuko Hara, Harukazu Suzuki, Jun Kikuchi, Ikuyo Inoue, Timo Lassmann, Hideki Tatsukawa, Yoshihide Hayashizaki, Tomokazu Matsuura, Yutaka Furutani, Feifei Wei, Hideko Sone, Erik Arner, Soichi Kojima, Piero Carninci, Xian-Yang Qin, Keisuke Nagatsuma
Publikováno v:
EBioMedicine, Vol 24, Iss C, Pp 257-266 (2017)
EBioMedicine
EBioMedicine
The acute phase protein orosomucoid-1 (Orm1) is mainly expressed by hepatocytes (HPCs) under stress conditions. However, its specific function is not fully understood. Here, we report a role of Orm1 as an executer of HPC proliferation. Increases in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e9e2186dab5bf3de7d390ed71053d8
https://doi.org/10.1016/j.ebiom.2017.09.008
https://doi.org/10.1016/j.ebiom.2017.09.008
Autor:
Kyoko Itoh, Yuta Aida, Hiroshi Abe, Yoshio Aizawa, Yoichi Tomita, Satoshi Sutoh, Tomonori Sugita, Keisuke Nagatsuma, Tomohisa Nagano, Tomokazu Matsuura, Nobuyoshi Seki, Munenori Itagaki
Publikováno v:
Journal of Gastroenterology and Hepatology. 30:1376-1383
Background and Aim We aimed to clarify the influences of aldehyde dehydrogenase 2 (ALDH2), alcohol dehydrogenase 1B (ADH1B) polymorphisms, and ethanol consumption profile to hepatocellular carcinoma (HCC) development in alcoholic liver cirrhosis with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5952f0a5cc7cf4a683aabd7a49bb79e4
https://doi.org/10.1111/jgh.12948
https://doi.org/10.1111/jgh.12948
Autor:
Takahiro Masaki, Keisuke Nagatsuma, Yoshihiro Mezaki, Naofumi Kimura, Madoka Nakagomi, Tomokazu Matsuura, Mariko Nakamura, Hiroshi Yokoyama, Sabine S. Gouraud, Jonghyuk Park, Takahiko J. Fujimi, Haruka Maehashi
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189346 (2017)
PLoS ONE
PLoS ONE
Background and aims We developed a bio-artificial liver (BAL) using a radial-flow bioreactor and rescued mini-pig models with lethal acute liver failure (ALF). The point of the rescue is the recovery from hepatic encephalopathy (HE). HE on ALF has so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6419a57b657e7c386062e5dd4e2d6c71
http://europepmc.org/articles/PMC5720809?pdf=render
http://europepmc.org/articles/PMC5720809?pdf=render