Výsledky vyhledávání - "Keisuke, Nagano"

Akademický článek

Cilostazol Induces PGI2 Production via Activation of the Downstream Epac-1/Rap1 Signaling Cascade to Increase Intracellular Calcium by PLCε and to Activate p44/42 MAPK in Human Aortic Endothelial Cells.

Autor: Ayako Hashimoto, Michinori Tanaka, Satoshi Takeda, Hideki Ito, Keisuke Nagano

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0132835 (2015)

Cilostazol, a selective phosphodiesterase 3 (PDE3) inhibitor, is known as an anti-platelet drug and acts directly on platelets. Cilostazol has been shown to exhibit vascular protection in ischemic diseases. Although vascular endothelium-derived prost

Externí odkaz: https://doaj.org/article/28ba264ee24b4258a53a715c1208d144

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Akademický článek

Cilostazol inhibits accumulation of triglyceride in aorta and platelet aggregation in cholesterol-fed rabbits.

Autor: Hideki Ito, Kenji Uehara, Yutaka Matsumoto, Ayako Hashimoto, Chifumi Nagano, Manabu Niimi, Goro Miyakoda, Keisuke Nagano

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e39374 (2012)

Cilostazol is clinically used for the treatment of ischemic symptoms in patients with chronic peripheral arterial obstruction and for the secondary prevention of brain infarction. Recently, it has been reported that cilostazol has preventive effects

Externí odkaz: https://doaj.org/article/300c19786a9747c8885aa7b7d4cabaae

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1-g shaking table tests on seismic enhancement of existing box culvert with partial ground-improvement method and its 2D dynamic simulation

Autor: Haruki Nishi, Keisuke Nagano, Hamayoon Kheradi, Feng Zhang

Publikováno v: Soils and Foundations. 58:563-581

An underground structure buried in a soft ground located in a seismic-active region may experience intolerable deformation due to earthquake loading. The collapse of Daikai Station of the Kobe subway line during the 1995 Hyogoken-Nambu Earthquake dem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::632d173080251677b487880492310589
https://doi.org/10.1016/j.sandf.2018.01.002

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The antimalarial drugs chloroquine and primaquine inhibit pyridoxal kinase, an essential enzyme for vitamin B6 production

Autor: Ryutaro Shirakawa, Takashi Hayashi, Keisuke Nagano, Hisanori Horiuchi, Tomohiro Kimura, Nobuhiro Yaoita

Publikováno v: FEBS Letters. 588:3673-3676

Quinoline derivatives such as chloroquine and primaquine are widely used for the treatment of malaria. These drugs are also used for the treatment of trypanosomiasis, and more recently for cancer therapy. However, molecular target(s) of these drugs r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7b6133c1620b351cf82b946ed44ba0
https://doi.org/10.1016/j.febslet.2014.08.011

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Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity

Autor: Tetsuya Yamada, Hisanori Horiuchi, Tomohiro Kimura, Masahiro Nishibori, Takahiro Horiuchi, Keisuke Nagano, Hideki Katagiri, Takashi Hayashi, Natsumi Sakata, Keyue Liu, Yoshihiro Narumi, Ryutaro Shirakawa, Sohei Tsukita

Publikováno v: The Journal of Biological Chemistry

Metformin is the first-line drug in the treatment of type 2 diabetes. In addition to its hypoglycemic effect, metformin has an anti-inflammatory function, but the precise mechanism promoting this activity remains unclear. High mobility group box 1 (H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d0c98ff022349017607237f0e66e3d
https://pubmed.ncbi.nlm.nih.gov/28373282

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Identification of the active region responsible for the anti-thrombotic activity of anopheline anti-platelet protein from a malaria vector mosquito

Autor: Hideki Hayashi, Toshiki Sudo, Hiroyuki Matsuoka, Hiroyuki Kyushiki, Mitsuhiro Iyori, Keisuke Nagano, Shigeto Yoshida

Publikováno v: Platelets. 24:324-332

We previously identified an anti-platelet protein, anopheline anti-platelet protein (AAPP), from the salivary gland of female Anopheles stephensi (a mosquito vector of human malaria). AAPP specifically blocks platelet adhesion to collagen by binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81800c4cc35b8618d9c2e67e685ebbe2
https://doi.org/10.3109/09537104.2012.698430

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Ubiquitin Ligase Cbl-b Is a Negative Regulator for Insulin-Like Growth Factor 1 Signaling during Muscle Atrophy Caused by Unloading

Autor: Edward M. Mills, Jumpei Goto, Takeshi Nikawa, Kenneth M. Baldwin, Koji Yasutomo, Shin'ichi Takeda, Akira Higashibata, Kazumi Ishidoh, Keisuke Nagano, Reiko Nakao, Ikuya Nonaka, Ayako Ohno, Natsuo Yasui, Eiki Kominami, Keiji Tanaka, Chiharu Yamada, Katsuya Hirasaka, Yuushi Okumura

Publikováno v: Molecular and Cellular Biology. 29:4798-4811

Skeletal muscle atrophy caused by unloading is characterized by both decreased responsiveness to myogenic growth factors (e.g., insulin-like growth factor 1 [IGF-1] and insulin) and increased proteolysis. Here, we show that unloading stress resulted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fcb49b142a0b21d049f7f798e95fd5
https://doi.org/10.1128/mcb.01347-08

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