Feasibility of a randomized single-blind crossover trial to assess the effects of the second-generation slow-release dopamine agonists pramipexole and ropinirole on cued recall memory in idiopathic mild or moderate Parkinson's disease without cognitive impairment

Autor: Keira L. Watts, Michael Murray, Thomas A. Shepherd, Simon J. Ellis, Laura Longshaw, Andrew R. Mayes, Julius Sim, Nicola M.J. Edelstyn

Publikováno v: Pilot and Feasibility Studies, Vol 4, Iss 1, Pp 1-12 (2017)
Pilot and Feasibility Studies
Shepherd, T A, Edelstyn, N M J, Longshaw, L, Sim, J, Watts, K, Mayes, A R, Murray, M & Ellis, S J 2018, ' Feasibility of a randomized single-blind crossover trial to assess the effects of the second-generation slow-release dopamine agonists pramipexole and ropinirole on cued recall memory in idiopathic mild or moderate Parkinson's disease without cognitive impairment ', Pilot and Feasibility Studies, vol. 4, no. 1, 11 . https://doi.org/10.1186/s40814-017-0154-7

Background The aim was to assess the feasibility of a single-centre, single-blind, randomized, crossover design to explore the effects of two slow-release dopamine agonists, ropinirole and pramipexole, on cued recall in Parkinson’s disease. As the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c34bd19632db6eded73c31becc422d

Connective tissue growth factor expression and induction by transforming growth factor-β is abrogated by simvastatin via a Rho signaling mechanism

Autor: Monica A. Spiteri, Keira L. Watts

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 287:L1323-L1332

Connective tissue growth factor (CTGF), a potent profibrotic mediator, acts downstream and in concert with transforming growth factor (TGF)-β to drive fibrogenesis. Significant upregulation of CTGF has been reported in fibrogenic diseases, including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043530c398b92bf618ba5f9e1c30379a
https://doi.org/10.1152/ajplung.00447.2003

Repression of IP-10 by interactions between histone deacetylation and hypermethylation in idiopathic pulmonary fibrosis

Autor: Linhua Pang, Keira L. Watts, Gisli Jenkins, Carol Feghali-Bostwick, William R. Coward

Publikováno v: Molecular and cellular biology. 30(12)

Targeted repression of a subset of key genes involved in tissue remodeling is a cardinal feature of idiopathic pulmonary fibrosis (IPF). The mechanism is unclear but is potentially important in disease pathogenesis and therapeutic targeting. We have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d18fbcd55c7dcabdfc515d58d439a28
https://pubmed.ncbi.nlm.nih.gov/20404089

Defective Histone Acetylation Is Responsible for the Diminished Expression of Cyclooxygenase-2 in Idiopathic Pulmonary Fibrosis

Autor: Carol Feghali-Bostwick, Alan J. Knox, Keira L. Watts, William R. Coward, Linhua Pang

Publikováno v: C19. BEYOND THE CODE: EPIGENETICS IN DIFFERENTIATION AND DISEASE.

Diminished cyclooxygenase 2 (COX-2) expression in fibroblasts, with a resultant defect in the production of the antifibrotic mediator prostaglandin E(2), plays a key role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Here, we have chara

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0e5edc8d5a833015e48e5712e21bcec
https://doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3977