Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Keira J.A. Johnston"'
Publikováno v:
HGG Advances, Vol 6, Iss 1, Pp 100381- (2025)
Summary: Chronic overlapping pain conditions (COPCs) are a subset of chronic pain conditions commonly comorbid with one another and more prevalent in women and individuals assigned female at birth (AFAB). Pain experience in these conditions may bette
Externí odkaz:
https://doaj.org/article/a27724388baf496089ebcb0acd719d54
Autor:
Rona J. Strawbridge, Joey Ward, Amy Ferguson, Nicholas Graham, Richard J. Shaw, Breda Cullen, Robert Pearsall, Laura M. Lyall, Keira J.A. Johnston, Claire L. Niedzwiedz, Jill P. Pell, Daniel Mackay, Julie Langan Martin, Donald M. Lyall, Mark E.S. Bailey, Daniel J. Smith
Publikováno v:
EBioMedicine, Vol 41, Iss , Pp 517-525 (2019)
Background: Suicide is a major issue for global public health. Suicidality describes a broad spectrum of thoughts and behaviours, some of which are common in the general population. Although suicide results from a complex interaction of multiple soci
Externí odkaz:
https://doaj.org/article/4f2c70fc50b2469c8422fb03da4fd838
Autor:
Amy Ferguson, Laura M. Lyall, Joey Ward, Rona J. Strawbridge, Breda Cullen, Nicholas Graham, Claire L. Niedzwiedz, Keira J.A. Johnston, Daniel MacKay, Stephany M. Biello, Jill P. Pell, Jonathan Cavanagh, Andrew M. McIntosh, Aiden Doherty, Mark E.S. Bailey, Donald M. Lyall, Cathy A. Wyse, Daniel J. Smith
Publikováno v:
EBioMedicine, Vol 35, Iss , Pp 279-287 (2018)
Background: Circadian rhythms are fundamental to health and are particularly important for mental wellbeing. Disrupted rhythms of rest and activity are recognised as risk factors for major depressive disorder and bipolar disorder. Methods: We conduct
Externí odkaz:
https://doaj.org/article/fed05692b32a4ed1b43ef09cdbe0cc87
Autor:
Laura M. Lyall, Joey Ward, Rona J. Strawbridge, Daniel J. Smith, Richard J. Shaw, Breda Cullen, Amy Ferguson, Mark E.S. Bailey, Nicholas Graham, Rachana Tank, Robert Pearsall, Jill P. Pell, Donald M. Lyall, Keira J.A. Johnston
Publikováno v:
Arterioscler Thromb Vasc Biol
Strawbridge, R J, Ward, J, Bailey, M E S, Cullen, B, Ferguson, A, Graham, N, Johnston, K J A, Lyall, L M, Pearsall, R, Pell, J, Shaw, R J, Tank, R, Lyall, D M & Smith, D J 2019, ' Carotid intima-media thickness novel loci, sex-specific effects, and genetic correlations with obesity and glucometabolic traits in UK Biobank ', Arteriosclerosis, Thrombosis, and Vascular Biology, pp. 446-461 . https://doi.org/10.1161/ATVBAHA.119.313226
Strawbridge, R J, Ward, J, Bailey, M E S, Cullen, B, Ferguson, A, Graham, N, Johnston, K J A, Lyall, L M, Pearsall, R, Pell, J, Shaw, R J, Tank, R, Lyall, D M & Smith, D J 2019, ' Carotid intima-media thickness novel loci, sex-specific effects, and genetic correlations with obesity and glucometabolic traits in UK Biobank ', Arteriosclerosis, Thrombosis, and Vascular Biology, pp. 446-461 . https://doi.org/10.1161/ATVBAHA.119.313226
Objective: Atherosclerosis is the underlying cause of most cardiovascular disease, but mechanisms underlying atherosclerosis are incompletely understood. Ultrasound measurement of the carotid intima-media thickness (cIMT) can be used to measure vascu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d37f5e390f50f3ca5a0b621b09e5c73e
https://doi.org/10.1161/atvbaha.119.313226
https://doi.org/10.1161/atvbaha.119.313226
Autor:
Laura D Howe, Marcus R. Munafò, Keira J.A. Johnston, Daniel J. Smith, Frank Popham, Desmond Campbell, Evangelia Demou, Rona J. Strawbridge, Neil M Davies, Michael J. Green, Sean Harrison, Srinivasa Vittal Katikireddi, Joey Ward
Publikováno v:
Campbell, D, Green, M, Davies, N M, Demou, E, Ward, J, Howe, L D, Harrison, S, Johnston, K, Strawbridge, R J, Popham, F, Smith, D, Munafo, M R & Katikireddi, S V 2021, ' Effects of increased body mass index on employment status : A Mendelian randomisation study ', International Journal of Obesity, vol. 45, no. 8, pp. 1790-1801 . https://doi.org/10.1038/s41366-021-00846-x
International Journal of Obesity (2005)
Campbell, D D, Green, M, Davies, N, Demou, E, Ward, J, Howe, L D, Harrison, S, Johnston, K J A, Strawbridge, R J, Popham, F, Smith, D J, Munafò, M R & Katikireddi, S V 2021, ' Effects of increased body mass index on employment status : a Mendelian randomisation study ', International Journal of Obesity . https://doi.org/10.1038/s41366-021-00846-x
International Journal of Obesity (2005)
Campbell, D D, Green, M, Davies, N, Demou, E, Ward, J, Howe, L D, Harrison, S, Johnston, K J A, Strawbridge, R J, Popham, F, Smith, D J, Munafò, M R & Katikireddi, S V 2021, ' Effects of increased body mass index on employment status : a Mendelian randomisation study ', International Journal of Obesity . https://doi.org/10.1038/s41366-021-00846-x
Background The obesity epidemic may have substantial implications for the global workforce, including causal effects on employment, but clear evidence is lacking. Obesity may prevent people from being in paid work through poor health or through socia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa399216eec65e4bbe454a940522409a
https://research-information.bris.ac.uk/ws/files/309542836/s41366_021_00846_x.pdf
https://research-information.bris.ac.uk/ws/files/309542836/s41366_021_00846_x.pdf
Autor:
Daniel J. Smith, Laura M. Lyall, Keira J.A. Johnston, Angela Silveira, Bruna Gigante, Joey Ward, Amy Ferguson, Hugh Watkins, Bengt Sennblad, Anuj Goel, Philippe Giral, Fabrizio Veglia, Breda Cullen, Damiano Baldassarre, Steve E. Humphries, Julia Morris, Anders Hamsten, Elena Tremoli, Donald M. Lyall, Rona J. Strawbridge, Ulf de Faire, Nicholas Graham, Mark E.S. Bailey, Andries J. Smit
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-43861-9⟩
Scientific Reports, 9:7339. Nature Publishing Group
Morris, J, Bailey, M E S, Baldassarre, D, Cullen, B, de Faire, U, Ferguson, A, Gigante, B, Giral, P, Goel, A, Graham, N, Hamsten, A, Humphries, S E, Johnston, K J A, Lyall, D M, Lyall, L M, Sennblad, B, Silveira, A, Smit, A J, Tremoli, E, Veglia, F, Ward, J, Watkins, H, Smith, D J & Strawbridge, R J 2019, ' Genetic variation in CADM2 as a link between psychological traits and obesity ', Scientific Reports, vol. 9, no. 1, pp. 7339 . https://doi.org/10.1038/s41598-019-43861-9
Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-43861-9⟩
Scientific Reports, 9:7339. Nature Publishing Group
Morris, J, Bailey, M E S, Baldassarre, D, Cullen, B, de Faire, U, Ferguson, A, Gigante, B, Giral, P, Goel, A, Graham, N, Hamsten, A, Humphries, S E, Johnston, K J A, Lyall, D M, Lyall, L M, Sennblad, B, Silveira, A, Smit, A J, Tremoli, E, Veglia, F, Ward, J, Watkins, H, Smith, D J & Strawbridge, R J 2019, ' Genetic variation in CADM2 as a link between psychological traits and obesity ', Scientific Reports, vol. 9, no. 1, pp. 7339 . https://doi.org/10.1038/s41598-019-43861-9
CADM2 has been associated with a range of behavioural and metabolic traits, including physical activity, risk-taking, educational attainment, alcohol and cannabis use and obesity. Here, we set out to determine whether CADM2 contributes to mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5489ce8bf689e3af00bacb1a7415f06b
http://link.springer.com/article/10.1038/s41598-019-43861-9
http://link.springer.com/article/10.1038/s41598-019-43861-9
Autor:
Cynthia Sandor, Laura M. Lyall, Valentina Escott-Price, Caleb Webber, Joey Ward, Keira J.A. Johnston, Daniel J. Smith, Michael Conlon O'Donovan, Nicholas Graham, Elizabeth M. Tunbridge, Donald M. Lyall, Paul Harrison, Amy Ferguson, Mark E.S. Bailey, Jill P. Pell, Breda Cullen, Rona J. Strawbridge
Publikováno v:
Ward, J, Tunbridge, E M, Sandor, C, Lyall, L M, Ferguson, A, Strawbridge, R J, Lyall, D M, Cullen, B, Graham, N, Johnston, K J A, Webber, C, Escott-Price, V, O'Donovan, M, Pell, J P, Bailey, M E S, Harrison, P J & Smith, D J 2020, ' The genomic basis of mood instability : identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function ', Molecular Psychiatry, vol. 25, no. 11, pp. 3091-3099 . https://doi.org/10.1038/s41380-019-0439-8
Molecular psychiatry
Molecular Psychiatry
Molecular psychiatry
Molecular Psychiatry
Genome-wide association studies (GWAS) of psychiatric phenotypes have tended to focus on categorical diagnoses, but to understand the biology of mental illness it may be more useful to study traits which cut across traditional boundaries. Here we rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c78d54c0ea7a55c8774f8e7eb0f98b7
https://orca.cardiff.ac.uk/id/eprint/123563/7/s41380-019-0439-8.pdf
https://orca.cardiff.ac.uk/id/eprint/123563/7/s41380-019-0439-8.pdf
Autor:
Theodore J. Price, Blair H. Smith, Joey Ward, Daniel J. Smith, Pradipta R. Ray, Rona J. Strawbridge, Mark Adams, Mark E.S. Bailey, Keira J.A. Johnston, Andrew M. McIntosh, Barbara I. Nicholl
Publikováno v:
Johnston, K J A, Ward, J, Ray, P R, Adams, M J, Mcintosh, A M, Smith, B H, Strawbridge, R J, Price, T J, Smith, D J, Nicholl, B I, Bailey, M E S & Epstein, M P (ed.) 2021, ' Sex-stratified genome-wide association study of multisite chronic pain in UK Biobank ', PLoS Genetics, vol. 17, no. 4, pp. e1009428 . https://doi.org/10.1371/journal.pgen.1009428
PLoS Genetics
PLoS Genetics, Vol 17, Iss 4, p e1009428 (2021)
PLoS Genetics
PLoS Genetics, Vol 17, Iss 4, p e1009428 (2021)
Chronic pain is highly prevalent worldwide and imparts a significant socioeconomic and public health burden. Factors influencing susceptibility to, and mechanisms of, chronic pain development, are not fully understood, but sex is thought to play a si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c2a9c5ef56c3e53e4e713df5d9a644
Autor:
Daniel J. Smith, Donald M. Lyall, Richard A. I. Bethlehem, Breda Cullen, Nicholas Graham, Graham K. Murray, Laura M. Lyall, Amy Ferguson, Joey Ward, Mark E.S. Bailey, Rona J. Strawbridge, Keira J.A. Johnston
Publikováno v:
Translational Psychiatry, Vol 9, Iss 1, Pp 1-9 (2019)
Ward, J, Lyall, L M, Bethlehem, R A I, Ferguson, A, Strawbridge, R J, Lyall, D M, Cullen, B, Graham, N, Johnston, K J A, Bailey, M E S, Murray, G K & Smith, D J 2019, ' Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure ', Translational Psychiatry, vol. 9, no. 1, pp. 327 . https://doi.org/10.1038/s41398-019-0635-y
Translational Psychiatry
Ward, J, Lyall, L M, Bethlehem, R A I, Ferguson, A, Strawbridge, R J, Lyall, D M, Cullen, B, Graham, N, Johnston, K J A, Bailey, M E S, Murray, G K & Smith, D J 2019, ' Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure ', Translational Psychiatry, vol. 9, no. 1, pp. 327 . https://doi.org/10.1038/s41398-019-0635-y
Translational Psychiatry
Anhedonia is a core feature of several psychiatric disorders but its biological underpinnings are poorly understood. We performed a genome-wide association study of anhedonia in 375,275 UK Biobank participants and assessed for genetic correlation bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec28f1d0c8f0dcfc8b140debcbaf407
https://www.repository.cam.ac.uk/handle/1810/300684
https://www.repository.cam.ac.uk/handle/1810/300684
Autor:
Olivia Burt, Breda Cullen, Rona J. Strawbridge, Donald M. Lyall, Daniel J. Smith, Jill P. Pell, Nicholas Graham, Laura M. Lyall, Joey Ward, Keira J.A. Johnston
Publikováno v:
Genes, Vol 12, Iss 1194, p 1194 (2021)
Genes
Volume 12
Issue 8
Burt, O, Johnston, K J A, Graham, N, Cullen, B, Lyall, D M, Lyall, L M, Pell, J P, Ward, J, Smith, D J & Strawbridge, R J 2021, ' Genetic Variation in the ASTN2 Locus in Cardiovascular, Metabolic and Psychiatric Traits: Evidence for Pleiotropy Rather Than Shared Biology ', Genes, vol. 12, no. 8, pp. 1194 . https://doi.org/10.3390/genes12081194
Genes
Volume 12
Issue 8
Burt, O, Johnston, K J A, Graham, N, Cullen, B, Lyall, D M, Lyall, L M, Pell, J P, Ward, J, Smith, D J & Strawbridge, R J 2021, ' Genetic Variation in the ASTN2 Locus in Cardiovascular, Metabolic and Psychiatric Traits: Evidence for Pleiotropy Rather Than Shared Biology ', Genes, vol. 12, no. 8, pp. 1194 . https://doi.org/10.3390/genes12081194
Background: The link between cardiometabolic and psychiatric illness has long been attributed to human behaviour, however recent research highlights shared biological mechanisms. The ASTN2 locus has been previously implicated in psychiatric and cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8516049e3be588e5d130b00ece40aec
https://doi.org/10.3390/genes12081194
https://doi.org/10.3390/genes12081194