Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Keinan B Agonias"'
Sarcomere length affects Ca2+ sensitivity of contraction in ischemic but not non-ischemic myocardium
Autor:
Bertrand C.W. Tanner, Peter O. Awinda, Keinan B. Agonias, Seetharamaiah Attili, Cheavar A. Blair, Mindy S. Thompson, Lori A. Walker, Thomas Kampourakis, Kenneth S. Campbell
Publikováno v:
Journal of General Physiology. 155
In healthy hearts, myofilaments become more sensitive to Ca2+ as the myocardium is stretched. This effect is known as length-dependent activation and is an important cellular-level component of the Frank–Starling mechanism. Few studies have measure
Autor:
Bertrand C.W. Tanner, Peter O. Awinda, Keinan B Agonias, Marissa Watanabe, Danuta Szczesna-Cordary, Anna M Huckabee, Katarzyna Kazmierczak, Yemeserach Bishaw
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 320:H881-H890
Mavacamten is a pharmaceutical that binds to myosin, and it is under investigation as a therapy for some forms of heart disease. We show that mavacamten reduces isometric tension and Ca2+ sensitivity of contraction in skinned myocardial strips from a
Autor:
Bertrand C.W. Tanner, Peter O. Awinda, Keinan B. Agonias, Cheavar A. Blair, Mindy S. Thompson, Lori A. Walker, Thomas Kampourakis, Kenneth S. Campbell
Publikováno v:
SSRN Electronic Journal.
Autor:
Peter O, Awinda, Marissa, Watanabe, Yemeserach, Bishaw, Anna M, Huckabee, Keinan B, Agonias, Katarzyna, Kazmierczak, Danuta, Szczesna-Cordary, Bertrand C W, Tanner
Publikováno v:
Am J Physiol Heart Circ Physiol
Morbidity and mortality associated with heart disease is a growing threat to the global population, and novel therapies are needed. Mavacamten (formerly called MYK-461) is a small molecule that binds to cardiac myosin and inhibits myosin ATPase. Mava