Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Keimpe D, Wierda"'
Autor:
Nuno Apóstolo, Samuel N. Smukowski, Jeroen Vanderlinden, Giuseppe Condomitti, Vasily Rybakin, Jolijn ten Bos, Laura Trobiani, Sybren Portegies, Kristel M. Vennekens, Natalia V. Gounko, Davide Comoletti, Keimpe D. Wierda, Jeffrey N. Savas, Joris de Wit
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Mossy fiber synapses are key in CA3 microcircuit function. Here, the authors profile the mossy fiber synapse proteome and cell-surface interactome. They uncover a diverse repertoire of cell-surface proteins and identify the receptor IgSF8 as a regula
Externí odkaz:
https://doaj.org/article/73f057183b374a89915c293d2ed3556b
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000466 (2019)
The pre- and postsynaptic membranes comprising the synaptic junction differ in protein composition. The membrane trafficking mechanisms by which neurons control surface polarization of synaptic receptors remain poorly understood. The sorting receptor
Externí odkaz:
https://doaj.org/article/aa921cae40804c9f9c6e01796fa78195
Autor:
Jeffrey N. Savas, Vasily Rybakin, Nuno Apóstolo, Joris de Wit, Natalia V. Gounko, Samuel N. Smukowski, Jolijn ten Bos, Laura Trobiani, Davide Comoletti, Giuseppe Condomitti, Jeroen Vanderlinden, Sybren Portegies, Keimpe D. Wierda, Kristel M. Vennekens
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Nature Communications
Nature Communications
Excitatory and inhibitory neurons are connected into microcircuits that generate circuit output. Central in the hippocampal CA3 microcircuit is the mossy fiber (MF) synapse, which provides powerful direct excitatory input and indirect feedforward inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dae873c2c28c92eb0329d7eeab65587
http://link.springer.com/article/10.1038/s41467-020-18956-x
http://link.springer.com/article/10.1038/s41467-020-18956-x
Autor:
Keimpe D. Wierda, Vasily Rybakin, Natalia V. Gounko, Pieter Baatsen, Dorien Vandael, Lieve Moons, Katlijn Vints, Lies De Groef
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry
Translational Psychiatry
Biological responses to internal and external stress factors involve highly conserved mechanisms, using a tightly coordinated interplay of many factors. Corticotropin-releasing factor (CRF) plays a central role in organizing these lifesaving physiolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3eb67b771f9fb6f40bfbb25a3fb588c
https://lirias.kuleuven.be/handle/123456789/678744
https://lirias.kuleuven.be/handle/123456789/678744
Autor:
De Strooper B, Kristofer Davie, Ashley Lu, Özturan G, Dietmar Rudolf Thal, Wei Ting Chen, Katleen Craessaerts, van Boekholdt L, Suresh Poovathingal, de Wit J, Mark Fiers, Keimpe D. Wierda, Calafate S, Nicola Thrupp, Creemers E, Jeroen Vanderlinden, Vandenbempt J
In Alzheimer’s disease (AD), pathophysiological changes in the hippocampus cause deficits in episodic memory formation, leading to cognitive impairment 1,2. Neuronal hyperactivity is observed early in AD 3,4. Here, we find that homeostatic mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dad2deafba5bcc306a33dd6275715e1
https://doi.org/10.1101/2021.05.21.445007
https://doi.org/10.1101/2021.05.21.445007
Autor:
Alfredo Cabrera-Socorro, Pei-Yu Shih, Juan Diego Pita Almenar, Jonathan De Smedt, Johanna Van Daele, Devesh Kumar, Tim Vervliet, Katrien Neyrinck, Astrid D'hondt, Melissa Nijs, Catherine M. Verfaillie, Mohamed Kreir, Geert Bultynck, Keimpe D. Wierda, Mélanie Planque, Tom Vanbokhoven, Andreas Ebneth, Vania Broccoli, Frederik Seibt, Sarah-Maria Fendt
Publikováno v:
Stem Cell Reviews and Reports
Astrocytes, the main supportive cell type of the brain, show functional impairments upon ageing and in a broad spectrum of neurological disorders. Limited access to human astroglia for pre-clinical studies has been a major bottleneck delaying our und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4ce022cf34f4dd721e63f788cea507
https://lirias.kuleuven.be/handle/123456789/675277
https://lirias.kuleuven.be/handle/123456789/675277
Autor:
Jef Swerts, Valerie Uytterhoeven, Nuno Apóstolo, Patrik Verstreken, Zsuzsanna Callaerts-Vegh, Pablo Largo-Barrientos, Keimpe D. Wierda, Bart De Strooper, Tara L. Spires-Jones, Caitlin Davies, Eline Creemers, Joris de Wit, Joseph McInnes
Publikováno v:
Largo-Barrientos, P, Apostolo, N, Creemers, E, Callaerts-Vegh, Z, Swerts, J, Davies, C, McInnes, J, Wierda, K, De Strooper, B, Spires-Jones, T, de Wit, J, Uytterhoeven, V & Verstreken, P 2021, ' Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation ', Neuron, vol. N/A, pp. 1-11.e1-e5 . https://doi.org/10.1016/j.neuron.2020.12.016
Neuron
Neuron
Tau is a major driver of neurodegeneration and is implicated in over 20 diseases. Tauopathies are characterized by synaptic loss and neuroinflammation, but it is unclear if these pathological events are causally linked. Tau binds to Synaptogyrin-3 on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac16a252e265e0580a33addcb866c78
https://www.pure.ed.ac.uk/ws/files/188885541/largo_barrientos.pdf
https://www.pure.ed.ac.uk/ws/files/188885541/largo_barrientos.pdf
Autor:
Ellis Pedersen, Trine Lisberg Toft-Bertelsen, Andreas B. Kønig, Jakob B. Sørensen, Casper René Gøtzsche, Irina Korshunova, Janne Nielsen, Melanie Schupp, Sylwia Owczarek, Michelle D. Gjørlund, Marie Louise Bang, Keimpe D. Wierda, Elisabeth Bock
Publikováno v:
Wierda, K D B, Toft-Bertelsen, T L, Gøtzsche, C R, Pedersen, E, Korshunova, I, Nielsen, J, Bang, M L, Kønig, A B, Owczarek, S, Gjørlund, M D, Schupp, M, Bock, E & Sørensen, J B 2020, ' The soluble neurexin-1β ectodomain causes calcium influx and augments dendritic outgrowth and synaptic transmission ', Scientific Reports, vol. 10, no. 1, 18041 . https://doi.org/10.1038/s41598-020-75047-z
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Classically, neurexins are thought to mediate synaptic connections through trans interactions with a number of different postsynaptic partners. Neurexins are cleaved by metalloproteases in an activity-dependent manner, releasing the soluble extracell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674388558f2e2e86d02f25c248aca62e
https://curis.ku.dk/portal/da/publications/the-soluble-neurexin1-ectodomain-causes-calcium-influx-and-augments-dendritic-outgrowth-and-synaptic-transmission(da8a9cb1-c710-4c4a-9321-574eaeb859d3).html
https://curis.ku.dk/portal/da/publications/the-soluble-neurexin1-ectodomain-causes-calcium-influx-and-augments-dendritic-outgrowth-and-synaptic-transmission(da8a9cb1-c710-4c4a-9321-574eaeb859d3).html
Autor:
Joke Terryn, Keimpe D. Wierda, Bart De Strooper, Alfredo Cabrera-Socorro, Frederic Lluis, Francisco Pestana, Andreas Ebneth, Laura Ordovás, Juan Antonio García-León, Ana Quiles, Catherine M. Verfaillie, Ann Swijsen, Fatemeharefeh Nami, Lutgarde Serneels, Kristel Eggermont, Raheem Fazal, Mohamed Kreir, Lieven Thorrez, Annerieke Sierksma, Philip Van Damme
Publikováno v:
Alzheimer's & Dementia. 14:1261-1280
INTRODUCTION: Tauopathies are neurodegenerative diseases characterized by TAU protein-related pathology, including frontotemporal dementia and Alzheimer's disease among others. Mutant TAU animal models are available, but none of them faithfully recap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de2a47a791c9ae9dfaae128748986f6
https://doi.org/10.1016/j.jalz.2018.05.007
https://doi.org/10.1016/j.jalz.2018.05.007
Autor:
Joris de Wit, Sven Vilain, Keimpe D. Wierda, Abigail G. Herrmann, Matthew Holt, Yu-Chun Wang, Patrik Verstreken, Bart De Strooper, Jelle Beyens, Ilse Dewachter, Lujia Zhou, Tara L. Spires-Jones, Diederik Moechars, Joseph McInnes, Jef Swerts, Rosemary J. Jackson, Katarzyna Miskiewicz
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications
Zhou, L, McInnes, J, Wierda, K, Holt, M, Herrmann, A G, Jackson, R J, Wang, Y-C, Swerts, J, Beyens, J, Miskiewicz, K, Vilain, S, Dewachter, I, Moechars, D, De Strooper, B, Spires-Jones, T L, De Wit, J & Verstreken, P 2017, ' Tau association with synaptic vesicles causes presynaptic dysfunction ', Nature Communications, vol. 8, 15295 . https://doi.org/10.1038/ncomms15295
Nature Communications
Zhou, L, McInnes, J, Wierda, K, Holt, M, Herrmann, A G, Jackson, R J, Wang, Y-C, Swerts, J, Beyens, J, Miskiewicz, K, Vilain, S, Dewachter, I, Moechars, D, De Strooper, B, Spires-Jones, T L, De Wit, J & Verstreken, P 2017, ' Tau association with synaptic vesicles causes presynaptic dysfunction ', Nature Communications, vol. 8, 15295 . https://doi.org/10.1038/ncomms15295
Tau is implicated in more than 20 neurodegenerative diseases, including Alzheimer's disease. Under pathological conditions, Tau dissociates from axonal microtubules and missorts to pre- and postsynaptic terminals. Patients suffer from early synaptic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d2a2ab4ee5bea82c948a7a46956481
https://doaj.org/article/29d0e0f57e0642e99099f85ef88b2518
https://doaj.org/article/29d0e0f57e0642e99099f85ef88b2518