Zobrazeno 1 - 10 of 55 pro vyhledávání: '"Keiko Wanaka"'
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Active site-directed plasmin inhibitors: Extension on the P2 residue
Autor: Keigo Gohda, Naoki Teno, Keiko Wanaka, Yuko Tsuda, Koushi Hidaka
Publikováno v: Bioorganic & Medicinal Chemistry. 24:545-553
Based on the structure of YO-2 [N-(trans-4-aminomethylcyclohexanecarbonyl)- l -Tyr(O-picolyl)-NH-octyl], active site-directed plasmin (Plm) inhibitors were explored. The picolyl moiety in the Tyr(O-picolyl) residue (namely, the P2 residue) was replac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b512c47e65686ad7a9d57e0f54e3b77a
https://doi.org/10.1016/j.bmc.2015.12.009
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4
Novel type of plasmin inhibitors: Providing insight into P4 moiety and alternative scaffold to pyrrolopyrimidine
Autor: Arisa Masuda, Mitsuhito Araki, Eriko Akiduki, Tadamune Otsubo, Maiko Akagawa, Naoki Teno, Keiko Wanaka, Yukiko Yamashita, Keigo Gohda, Yuko Tsuda
Publikováno v: Bioorganic & Medicinal Chemistry. 23:3696-3704
Here we report a series of plasmin inhibitors which were originally derived from the parent structure of 1 and 2. Our efforts focused on the optimization of the P4 moiety of 2 and on the quest of alternative scaffold to pyrrolopyrimidine in the paren
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b781bdc5ccd22e0d076b25880df645da
https://doi.org/10.1016/j.bmc.2015.04.013
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5
Pyrrolopyrimidine-inhibitors with hydantoin moiety as spacer can explore P4/S4 interaction on plasmin
Autor: Naoki Teno, Keigo Gohda, Yuko Tsuda, Tadamune Otsubo, Takuya Sueda, Yukiko Yamashita, Keiko Wanaka
Publikováno v: Bioorganic & Medicinal Chemistry. 22:2339-2352
In the development of plasmin inhibitors, a novel chemotype, pyrrolopyrimidine scaffold possessing two motifs, a hydantoin-containing P4 moiety and a warhead-containing P1 moiety, is uncovered. A unique feature of the new line of the plasmin inhibito
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156557a122a446ec3d184cf4ad231c86
https://doi.org/10.1016/j.bmc.2014.02.002
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6
Novel HIT antibody detection method using Sonoclot® coagulation analyzer
Autor: Kumiko Miyashita, Hirokazu Endo, Keiko Wanaka, Reiko Asada, Yutaka Yatomi, Makoto Kaneko
Publikováno v: Thrombosis Research. 135:127-129
Introduction Since heparin-induced thrombocytopenia (HIT), caused by the generation of antibodies against platelet factor 4 (PF4)/heparin complexes (HIT antibodies), may induce serious complications due to thrombosis, a prompt diagnosis is desirable.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a773fb3b1ee9eb91a036d48a12b525b5
https://doi.org/10.1016/j.thromres.2014.10.024
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7
Synthetic Substrates Specific to Activated Plasmin Can Monitor the Enzymatic Functional Statusin Situin Breast Cancer Cells
Autor: Naoki Teno, Keiko Wanaka, Ko Fujimori, Keigo Gohda, Yuko Tsuda
Publikováno v: Chemical Biology & Drug Design. 83:52-57
We here strove to overcome the limitations of expression analyses such as PCR and IHC, based on molecular recognition between target and probe molecules, by designing synthetic substrates specific to the target molecules to directly estimate the enzy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9038885b4dd925579a076a9a9bda1315
https://doi.org/10.1111/cbdd.12232
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8
Plasmin inhibitors with hydrophobic amino acid-based linker between hydantoin moiety and benzimidazole scaffold enhance inhibitory activity
Autor: Tadamune Otsubo, Yukiko Yamashita, Keigo Gohda, Keiko Wanaka, Yuko Tsuda, Naoki Teno, Masafumi Yamaguchi
Publikováno v: Bioorganicmedicinal chemistry letters. 26(9)
In this letter we report the design and synthesis of a series of plasmin inhibitors, which share the amino acid-based linker with limited free rotation between the hydantoin moiety and the benzimidazole scaffold. Our studies led to potent plasmin inh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b24bd46600f0e9c2839f67ac017a2f46
https://pubmed.ncbi.nlm.nih.gov/27009905
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9
Synthesis and evaluation of tripeptidic plasmin inhibitors with nitrile as warhead
Autor: Kiyoshi Ikeda, Yuko Tsuda, Takuya Sueda, Tadamune Otsubo, Akiko Hijikata-Okunomiya, Naoki Teno, Keiko Wanaka, Keigo Gohda
Publikováno v: Journal of Peptide Science. 18:620-625
Plasmin is best known as the key molecule in the fibrinolytic system, which is critical for clot lysis and can initiate matrix metalloproteinase (MMP) activation cascade. Along with MMP, plasmin is suggested to be involved in physiological processes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f661a8108e737605a2611a1203435bf
https://doi.org/10.1002/psc.2442
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10
Murine Monoclonal Antibody to Platelet Factor 4/Heparin Complexes as a Potential Reference Standard for Platelet Activation Assays in Heparin-Induced Thrombocytopenia
Autor: Margaret Prechel, Vicki Escalante, Chieko Kaneko, Mitsuru Oosawa, Jeanine M. Walenga, Kumiko Miyashita, Nobuhiro Hoshino, Miyako Matsuo, Reiko Asada, Keiko Wanaka
Publikováno v: Clinical and Applied Thrombosis/Hemostasis. 19:37-41
Quality control of the platelet activation assays to diagnose heparin-induced thrombocytopenia (HIT), (14)C-serotonin release assay (SRA) and platelet aggregation test (PAT) has yet to be established due to lack of reference standards and the difficu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3ec67358fe3a71db2b9f85d0b5d93c
https://doi.org/10.1177/1076029612453763
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