Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Keiko Tamiya-Koizumi"'
Autor:
Hanxiao Shi, Takashi Murate, Keiko Tamiya-Koizumi, Takashi Takahashi, Naoki Mizutani, Yoshinori Hasegawa, Tetsuo Taniguchi, Keiko Wakahara, Kouji Tanaka, Takayuki Fukui, Motoshi Suzuki, Seiichi Kato, Atsuko Niimi, Mamoru Kyogashima, Satoshi Fujii, Soichiro Iwaki, Ke Cao, Norie Nakatani, Yukiko Mizutani, Yasuyoshi Mizutani, Chinatsu Arima, Kohei Yokoi, Shuta Tomida, Akira Satou, Kiyoshi Yanagisawa, Toshiyuki Takeuchi, Mei Chee Tai
Publikováno v:
Journal of Cellular and Molecular Medicine
Sphingolipids constitute a class of bio‐reactive molecules that transmit signals and exhibit a variety of physical properties in various cell types, though their functions in cancer pathogenesis have yet to be elucidated. Analyses of gene expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a60a89ffb7b910c3518bac00d6908d
https://pubmed.ncbi.nlm.nih.gov/32902157
https://pubmed.ncbi.nlm.nih.gov/32902157
Autor:
Satoshi Fujii, Chinatsu Arima, Kohei Yokoi, Naoki Mizutani, Takashi Murate, Takashi Takahashi, Keiko Tamiya-Koizumi, Takahiro Shiraishi, Kouji Tanaka, Yasuyuki Igarashi, Ke Cao, Mei Chee Tai, Tetsuo Taniguchi, Yukiko Mizutani, Takayuki Fukui, Motoshi Suzuki, Noriyasu Usami, Yoshinori Hasegawa, Kiyoshi Yanagisawa, Akira Satou, Yoko Matsumoto, Keiko Wakahara, Mitsuhiro Nakamura, Mamoru Kyogashima, Ryuichi Ueoka, Seiichi Kato, Norie Togawa, Yuji Komizu, Soichiro Iwaki, Jin-ichi Inokuchi
Sphingolipids make up a family of molecules associated with an array of biological functions, including cell death and migration. Sphingolipids are often altered in cancer, though how these alterations lead to tumor formation and progression is large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ccbf6b709431999a53dfc068865501a
https://europepmc.org/articles/PMC6819117/
https://europepmc.org/articles/PMC6819117/
Autor:
Naoki Mizutani, Yasuyuki Igarashi, Jin-ichi Inokuchi, Ke Cao, Soichiro Iwaki, Takayuki Fukui, Chinatsu Arima, Noriyasu Usami, Tetsuo Taniguchi, Kohei Yokoi, Yoko Matsumoto, Keiko Wakahara, Takashi Takahashi, Ryuichi Ueoka, Yuji Komizu, Mamoru Kyogashima, Satoshi Fujii, Kiyoshi Yanagisawa, Yukiko Mizutani, Mei Chee Tai, Akira Satou, Seiichi Kato, Norie Togawa, Kouji Tanaka, Motoshi Suzuki, Yoshinori Hasegawa, Takashi Murate, Keiko Tamiya-Koizumi, Mitsuhiro Nakamura, Takahiro Shiraishi
Publikováno v:
Journal of Clinical Investigation. 126:3036-3052
In preclinical models of glioblastoma, antigen escape variants can lead to tumor recurrence after treatment with CAR T cells that are redirected to single tumor antigens. Given the heterogeneous expression of antigens on glioblastomas, we hypothesize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e313d24048ddf5c12e835a83d7e9fb
https://doi.org/10.1172/jci83416
https://doi.org/10.1172/jci83416
Autor:
Yukari Omori, Takashi Murate, Keiko Tamiya-Koizumi, Mamoru Kyogashima, Yoshinori Nozawa, Sayaka Sobue, Motoshi Suzuki, Yoshiyuki Kawamoto, Mitsuhiro Nakamura, Masatoshi Ichihara, Naoki Mizutani
Publikováno v:
Biochemical and Biophysical Research Communications. 470:851-856
Resveratrol (RSV) is a plant-derived phytoalexin present in plants, whose pleiotropic effects for health benefits have been previously reported. Its anti-cancer activity is among the current topics for novel cancer treatment. Here, effects of RSV on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ca9ebc8f2804d3062de901da1eb699
https://doi.org/10.1016/j.bbrc.2016.01.134
https://doi.org/10.1016/j.bbrc.2016.01.134
Autor:
Akira Takagi, Mamoru Kyogashima, Koji Tanaka, Hideo Ogiso, Yukari Omori, Hiromi Ito, Mitsuhiro Nakamura, Takashi Murate, Yoshinori Nozawa, Tetsuhito Kojima, Keiko Tamiya-Koizumi, Motoshi Suzuki, Yoshiyuki Kawamoto, Naoki Mizutani, Masahiro Nakatochi
Publikováno v:
Journal of Cellular Biochemistry. 116:2227-2238
Sphingosine kinases (SPHK) are important to determine cells' fate by producing sphingosine 1-phosphate. Reportedly, exogenous SPHK2 overexpression induces cell cycle arrest or cell death. However, the regulatory mechanism of SPHK2 expression has not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f1dbf216302930ab45f6d7cf1336afc
https://doi.org/10.1002/jcb.25173
https://doi.org/10.1002/jcb.25173
Autor:
Naoki Mizutani, Yoshinori Nozawa, Takashi Murate, Keiko Tamiya-Koizumi, Hiromi Ito, Motoshi Suzuki, Akira Takagi, Yukari Omori, Tetsuhito Kojima, Mitsuhiro Nakamura, Masahiro Nakatochi, Minami Inoue, Soichiro Iwaki
Publikováno v:
Journal of Biochemistry. 158:309-319
Acid ceramidase (ACDase) metabolizes ceramide to sphingosine, leading to sphingosine 1-phosphate production. Reportedly, ACDase has been upregulated in prostate cancer. However, its regulatory mechanism remains unclear. LNCaP (androgen-sensitive pros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d784ca7db2f22b1d0ca7e94437c64f9b
https://doi.org/10.1093/jb/mvv039
https://doi.org/10.1093/jb/mvv039
Autor:
Yayoi Nishida, Minami Inoue, Yukari Omori, Yosuke Minami, Takashi Murate, Keiko Tamiya-Koizumi, Naoki Mizutani, Yoshinori Nozawa, Motoshi Suzuki, Tetsuhito Kojima, Akira Takagi, Kazunori Ohnishi, Tomoki Naoe
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1839:265-274
Multidrug resistance (MDR) is a serious problem faced in the treatment of malignant tumors. In this study, we characterized the expression of non-homologous DNA end joining (NHEJ) components, a major DNA double strand break (DSB) repair mechanism in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ab083dea7b22e684e8f0d7e208aba0
https://doi.org/10.1016/j.bbagrm.2014.02.004
https://doi.org/10.1016/j.bbagrm.2014.02.004
Autor:
Naoki Mizutani, Akira Takagi, Masatoshi Ichihara, Yoshiko Banno, Takashi Murate, Tetsuhito Kojima, Keiko Tamiya-Koizumi, Hiromi Ito, Mitsuhiro Nakamura, Sayaka Sobue, Yoshinori Nozawa, Kouji Tanaka, Motoshi Suzuki, Tomoki Naoe, Yasutomo Ito, Satoshi Fujii, Misa Kobayashi, Soichiro Iwaki
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1833:1006-1016
Sphingosine kinase 1 (SPHK1) overexpression in malignant cells has been reported. Mouse Friend cells showed higher SPHK1 but not SPHK2 expression compared with other mouse cell lines. A Sphk1 promoter analysis demonstrated the region between − 53 b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c103b21daa8a1b520f909fcc04b5b313
https://doi.org/10.1016/j.bbamcr.2013.01.001
https://doi.org/10.1016/j.bbamcr.2013.01.001
Autor:
Mamoru Kyogashima, Kouji Tanaka, Takashi Murate, Masaki Yamada, Keiko Tamiya-Koizumi, Reiji Kannagi
Publikováno v:
Glycoconjugate journal. 32(8)
Oxygen-requiring enzymes, such as Δ4-desaturase (dihydroceramide desaturase), sphingolipid Δ4-desaturase/C-4-hydroxylase, and fatty acid 2-hydroxylase are involved in ceramide synthesis. We prepared free ceramides, sphingomyelins and glycosphingoli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878fd33ae536504df5be1921e7b1f0f2
https://pubmed.ncbi.nlm.nih.gov/26194060
https://pubmed.ncbi.nlm.nih.gov/26194060
Autor:
Naoki, Mizutani, Yukari, Omori, Koji, Tanaka, Hiromi, Ito, Akira, Takagi, Tetsuhito, Kojima, Masahiro, Nakatochi, Hideo, Ogiso, Yoshiyuki, Kawamoto, Mitsuhiro, Nakamura, Motoshi, Suzuki, Mamoru, Kyogashima, Keiko, Tamiya-Koizumi, Yoshinori, Nozawa, Takashi, Murate
Publikováno v:
Journal of cellular biochemistry. 116(10)
Sphingosine kinases (SPHK) are important to determine cells' fate by producing sphingosine 1-phosphate. Reportedly, exogenous SPHK2 overexpression induces cell cycle arrest or cell death. However, the regulatory mechanism of SPHK2 expression has not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3bbe87db413edb4d223f0049c3ab07c8
https://pubmed.ncbi.nlm.nih.gov/25808826
https://pubmed.ncbi.nlm.nih.gov/25808826