Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Keiko Shoji"'
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Akademický článek
Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423.
Autor: Tomoko Kashiyama, Katsutoshi Oda, Yuji Ikeda, Yoshinobu Shiose, Yasuhide Hirota, Kanako Inaba, Chinami Makii, Reiko Kurikawa, Aki Miyasaka, Takahiro Koso, Tomohiko Fukuda, Michihiro Tanikawa, Keiko Shoji, Kenbun Sone, Takahide Arimoto, Osamu Wada-Hiraike, Kei Kawana, Shunsuke Nakagawa, Koichi Matsuda, Frank McCormick, Hiroyuki Aburatani, Tetsu Yano, Yutaka Osuga, Tomoyuki Fujii
Publikováno v: PLoS ONE, Vol 9, Iss 2, p e87220 (2014)
DS-7423, a novel, small-molecule dual inhibitor of phosphatidylinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR), is currently in phase I clinical trials for solid tumors. Although DS-7423 potently inhibits PI3Kα (IC50 = 15.6 nM) and
Externí odkaz: https://doaj.org/article/ef12b6d8423a437b933c13dd9570c13b
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2
Akademický článek
Genotype-dependent efficacy of a dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas.
Autor: Keiko Shoji, Katsutoshi Oda, Tomoko Kashiyama, Yuji Ikeda, Shunsuke Nakagawa, Kenbun Sone, Yuichiro Miyamoto, Haruko Hiraike, Michihiro Tanikawa, Aki Miyasaka, Takahiro Koso, Yoko Matsumoto, Osamu Wada-Hiraike, Kei Kawana, Hiroyuki Kuramoto, Frank McCormick, Hiroyuki Aburatani, Tetsu Yano, Shiro Kozuma, Yuji Taketani
Publikováno v: PLoS ONE, Vol 7, Iss 5, p e37431 (2012)
The PI3K (phosphatidylinositol-3-kinase)/mTOR (mammalian target of rapamycin) pathway is frequently activated in endometrial cancer through various PI3K/AKT-activating genetic alterations. We examined the antitumor effect of NVP-BEZ235--a dual PI3K/m
Externí odkaz: https://doaj.org/article/deba6ac38326495e940cd4b60e0f2bad
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8
Data from PIK3CA Cooperates with Other Phosphatidylinositol 3′-Kinase Pathway Mutations to Effect Oncogenic Transformation
Autor: Frank McCormick, Kevan M. Shokat, Zachary A. Knight, Hiroyuki Kuramoto, Yuji Taketani, Keiko Shoji, David Stokoe, Pablo Rodriguez-Viciana, Luika Timmerman, Jennifer Okada, Katsutoshi Oda
Mutations in genes functioning in different pathways frequently occur together in the same cancer, whereas mutations in the same pathway tend to be mutually exclusive. However, the majority of colon, breast, and endometrial cancers that possess mutat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ac2e2158ef495de335ed42681b19195
https://doi.org/10.1158/0008-5472.c.6497862
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10
Aromatase inhibitor anastrozole as a second-line hormonal treatment to a recurrent low-grade endometrial stromal sarcoma: a case report
Autor: Shiro Kozuma, Katsutoshi Oda, Yuji Taketani, Yutaka Takazawa, Kei Kawana, Keiko Shoji, Yuji Ikeda, Toshiharu Yasugi, Shunsuke Nakagawa
Publikováno v: Medical Oncology. 28:771-774
Low-grade endometrial stromal sarcoma (ESS) is a rare neoplasm and is generally an indolent tumor with estrogen and progesterone receptors. Objective responses by hormonal treatment with progestin or aromatase inhibitor have been reported, however, l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e142e6f5e440f76c47221e6fe5b8966
https://doi.org/10.1007/s12032-010-9511-6
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