Zobrazeno 1 - 10
of 497
pro vyhledávání: '"Keiko NAKAYAMA"'
Autor:
Miki Watanabe-Matsui, Shun Kadoya, Kei Segawa, Hiroki Shima, Tadashi Nakagawa, Yuko Nagasawa, Shuichiro Hayashi, Mitsuyo Matsumoto, Mariko Ikeda, Akihiko Muto, Kyoko Ochiai, Long C. Nguyen, Katsumi Doh-Ura, Mikako Shirouzu, Keiko Nakayama, Kazutaka Murayama, Kazuhiko Igarashi
Publikováno v:
iScience, Vol 28, Iss 1, Pp 111529- (2025)
Summary: Heme is known to bind to the intrinsically disordered region (IDR) to regulate protein function. The binding of heme to the IDR of transcription factor BACH2 promotes plasma cell differentiation, but the molecular basis is unknown. Heme was
Externí odkaz:
https://doaj.org/article/98d104f654714a66b85ac8f7fb33ee3c
Autor:
Rumiko Izumi, Kensuke Ikeda, Tetsuya Niihori, Naoki Suzuki, Matsuyuki Shirota, Ryo Funayama, Keiko Nakayama, Hitoshi Warita, Maki Tateyama, Yoko Aoki, Masashi Aoki
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 3, Pp 577-592 (2024)
Abstract Objective Multisystem proteinopathy type 3 (MSP3) is an inherited, pleiotropic degenerative disorder caused by a mutation in heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1), which can affect the muscle, bone, and/or nervous system. This
Externí odkaz:
https://doaj.org/article/9c37292f249446f1a8c4290b97fe408c
Autor:
Hironari Nishizawa, Mitsuyo Matsumoto, Mie Yamanaka, Riko Irikura, Kazuma Nakajima, Keisuke Tada, Yoshiaki Nakayama, Morichika Konishi, Nobuyuki Itoh, Ryo Funayama, Keiko Nakayama, Kazuhiko Igarashi
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114403- (2024)
Summary: Ferroptosis is a type of regulated cell death characterized by iron-dependent lipid peroxidation. A model cell system is constructed to induce ferroptosis by re-expressing the transcription factor BACH1, a potent ferroptosis inducer, in immo
Externí odkaz:
https://doaj.org/article/e99568b0d1834b299cd30115e6501227
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107267- (2023)
Summary: Biological invasion refers to the introduction, spread, and establishment of non-native species in a novel habitat. The ways in which invasive species successfully colonize new and different environments remain a fundamental topic of researc
Externí odkaz:
https://doaj.org/article/6358768351d0437e8f25dab13aa482cb
Autor:
Katsuhiko Takahashi, Hitoshi Amano, Tomohiko Urano, Minqi Li, Meiko Oki, Kazuhiro Aoki, Norio Amizuka, Keiichi I. Nakayama, Keiko Nakayama, Nobuyuki Udagawa, Nobuaki Higashi
Publikováno v:
PLoS ONE, Vol 18, Iss 2 (2023)
A cyclin-dependent kinase (CDK) inhibitor, p57Kip2, is an important molecule involved in bone development; p57Kip2-deficient (p57-/-) mice display neonatal lethality resulting from abnormal bone formation and cleft palate. The modulator 1α,25-dihydr
Externí odkaz:
https://doaj.org/article/a71aa69fb2fa462f83fc66e330f4eba1
Publikováno v:
Frontiers in Genetics, Vol 13 (2023)
Genomic analysis has revealed that the genes for various chromatin regulators are mutated in many individuals with neurodevelopmental disorders (NDDs), emphasizing the important role of chromatin regulation in nervous system development and function.
Externí odkaz:
https://doaj.org/article/220e7714b9a447b5a624ba44132757de
Autor:
Atsushi Hozawa, Kozo Tanno, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Akira Narita, Mana Kogure, Kotaro Nochioka, Ryohei Sasaki, Nobuyuki Takanashi, Kotaro Otsuka, Kiyomi Sakata, Shinichi Kuriyama, Masahiro Kikuya, Osamu Tanabe, Junichi Sugawara, Kichiya Suzuki, Yoichi Suzuki, Eiichi N Kodama, Nobuo Fuse, Hideyasu Kiyomoto, Hiroaki Tomita, Akira Uruno, Yohei Hamanaka, Hirohito Metoki, Mami Ishikuro, Taku Obara, Tomoko Kobayashi, Kazuyuki Kitatani, Takako Takai-Igarashi, Soichi Ogishima, Mamoru Satoh, Hideki Ohmomo, Akito Tsuboi, Shinichi Egawa, Tadashi Ishii, Kiyoshi Ito, Sadayoshi Ito, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Masao Nagasaki, Kazuhiko Igarashi, Seizo Koshiba, Ritsuko Shimizu, Gen Tamiya, Keiko Nakayama, Hozumi Motohashi, Jun Yasuda, Atsushi Shimizu, Tsuyoshi Hachiya, Yuh Shiwa, Teiji Tominaga, Hiroshi Tanaka, Kotaro Oyama, Ryoichi Tanaka, Hiroshi Kawame, Akimune Fukushima, Yasushi Ishigaki, Tomoharu Tokutomi, Noriko Osumi, Tadao Kobayashi, Fuji Nagami, Hiroaki Hashizume, Tomohiko Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Ryujin Endo, Satoshi Nishizuka, Ichiro Tsuji, Jiro Hitomi, Motoyuki Nakamura, Kuniaki Ogasawara, Nobuo Yaegashi, Kengo Kinoshita, Shigeo Kure, Akio Sakai, Seiichiro Kobayashi, Kenji Sobue, Makoto Sasaki, Masayuki Yamamoto
Publikováno v:
Journal of Epidemiology, Vol 31, Iss 1, Pp 65-76 (2021)
Background: We established a community-based cohort study to assess the long-term impact of the Great East Japan Earthquake on disaster victims and gene-environment interactions on the incidence of major diseases, such as cancer and cardiovascular di
Externí odkaz:
https://doaj.org/article/64f92cd82beb4bfabc4ed85922f051b4
Autor:
Tadashi Nakagawa, Akane Morohoshi, Yuko Nagasawa, Makiko Nakagawa, Masaki Hosogane, Yasuhiro Noda, Toru Hosoi, Keiko Nakayama
Publikováno v:
Cell Reports, Vol 38, Iss 12, Pp 110541- (2022)
Summary: The histone chaperone complex FACT comprises SPT16 and SSRP1 and contributes to DNA replication, transcription, and repair, but how it plays such various roles is unclear. Here, we show that human SPT16 is ubiquitylated at lysine-674 (K674)
Externí odkaz:
https://doaj.org/article/acc2ec7278fc475baaf6a4baafc163bc
Autor:
Takashi Aizawa, Hideaki Karasawa, Ryo Funayama, Matsuyuki Shirota, Takashi Suzuki, Shimpei Maeda, Hideyuki Suzuki, Akihiro Yamamura, Takeshi Naitoh, Keiko Nakayama, Michiaki Unno
Publikováno v:
Cancer Medicine, Vol 8, Iss 14, Pp 6370-6382 (2019)
Abstract Recent studies have shown that the tumor microenvironment plays a significant role in the progression of solid tumors. As an abundant component of the tumor microenvironment, cancer‐associated fibroblasts (CAFs) have been shown to promote
Externí odkaz:
https://doaj.org/article/197ddeca2e3141819d281dfa70132d8b
Autor:
Michio Ozeki, Yoko Aoki, Akifumi Nozawa, Shiho Yasue, Saori Endo, Yumiko Hori, Kentaro Matsuoka, Tetsuya Niihori, Ryo Funayama, Matsuyuki Shirota, Keiko Nakayama, Toshiyuki Fukao
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 14, Iss 1, Pp 1-9 (2019)
Abstract Background Kaposiform lymphangiomatosis (KLA) has recently been distinguished as a novel subtype of generalized lymphatic anomaly (GLA) with foci of spindle endothelial cells. All cases of KLA involve multiple organs and have an unfavorable
Externí odkaz:
https://doaj.org/article/b6246cfbeb3548eaa352aee6bbce0d20