Výsledky vyhledávání - "Keiko Misawa"

Structure–activity relationship studies of imidazo[1,2-c]pyrimidine derivatives as potent and orally effective Syk family kinases inhibitors

Autor: Hiroaki Kobayashi, Motoyasu Ozawa, Harunobu Mukaiyama, Akihito Hirabayashi, Satoko Nakayama, Hiroaki Shiohara, Keiko Misawa, Eiichi Tsuji, Keiji Miyazawa, Masayuki Isaji, Hideki Ohnota

Publikováno v: Bioorganic & Medicinal Chemistry. 16:9247-9260

Spleen tyrosine kinase (Syk) and zeta-associated protein kinase of 70 kDa (ZAP-70) are members of the Syk family and non-receptor-type protein tyrosine kinases, which play crucial roles in B- and T-cell activation. Therefore, a Syk family tyrosine ki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e8455692c661f7759296dc68fb8891
https://doi.org/10.1016/j.bmc.2008.09.015

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A novel Syk family kinase inhibitor: Design, synthesis, and structure–activity relationship of 1,2,4-triazolo[4,3-c]pyrimidine and 1,2,4-triazolo[1,5-c]pyrimidine derivatives

Autor: Harunobu Mukaiyama, Motoyasu Ozawa, Keiko Misawa, Satoko Nakayama, Keiji Miyazawa, Hiroaki Kobayashi, Hiroaki Shiohara, Masayuki Isaji, Akihito Hirabayashi, Hideki Ohnota

Publikováno v: Bioorganic & Medicinal Chemistry. 16:7347-7357

Splenic tyrosine kinase (Syk) family kinases, which are members of the protein tyrosine kinase family, play crucial roles in immune responses, with Syk participating in B-cell activation and the zeta-associated protein 70 kDa (ZAP-70) kinase being in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e323a73ad0a7353bf5b24b4fcdd0cd
https://doi.org/10.1016/j.bmc.2008.06.017

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Characteristics of rat bone marrow cells differentiated into a liver cell lineage and dynamics of the transplanted cells in the injured liver

Autor: Koji Saito, Rika Ishii, Kazuhiko Sugahara, Sumio Kawata, Mai Sanjo, Akihiko Suzuki, Hiroaki Haga, Takafumi Saito, Keiko Misawa, Hitoshi Togashi, Etsuko Hattori, Junitsu Ito, Kazuo Okumoto, Tetsuru Karasawa

Publikováno v: Journal of Gastroenterology. 41:62-69

Bone marrow cells (BMCs) have been shown to differentiate into a liver cell lineage, but little is known about their dynamics following transplantation. BMCs were cultured to investigate the expression of liver-specific genes in vitro and transplante

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716c6128debc9ca4476841f0358be5bb
https://doi.org/10.1007/s00535-005-1723-8

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Highly selective detection of trace copper(II) using bathocuproinesulfonate by flow-injection electrospray ionization mass spectrometry

Autor: Keiko Misawa, Hideyuki Itabashi, Masanobu Mori

Publikováno v: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 30(12)

Trace Cu(2+) was detected with high selectivity using specific complexation with bathocuproinesulfonate (BCS) through flow-injection electrospray ionization mass spectrometry (FI-ESI-MS), which separates Cu(2+) from coexisting metal ions by forming a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba1de9d5eaf880baf4fcf94c15b1264
https://pubmed.ncbi.nlm.nih.gov/25492468

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Expression of Notch signalling markers in bone marrow cells that differentiate into a liver cell lineage in a rat transplant model

Autor: Koji Saito, Keiko Misawa, Takafumi Saito, Kazuhiko Sugahara, Junitsu Ito, Sumio Kawata, Kazuo Okumoto, Mai Sanjyo, Etsuko Hattori, Akihiko Suzuki, Hitoshi Togashi, Tadashi Takeda

Publikováno v: Hepatology Research. 31:7-12

Notch signalling pathway plays an important role in cell differentiation. To investigate the implications of Notch signalling in the differentiation of rat bone marrow (BM) cells into a liver cell lineage, we used cultured BM cells to examine the mRN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b271b49f069bbe54992b7eb0c25d425
https://doi.org/10.1016/j.hepres.2004.11.005

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Prophylactic Effects Of Pilocarpine Hydrochloride On Xerostomia Models Induced By X-Ray Irradiation In Rats

Autor: Keiko Misawa, Yoshimitsu Komatsu, Tetsuya Asari, Kiyoto Hara, Masuo Akahane

Publikováno v: Clinical and Experimental Pharmacology and Physiology. 28:545-550

1. In the present study, we investigated the prophylactic effects of pilocarpine hydrochloride on xerostomia models induced by either single (15 Gy) or repeated (8.6 Gy x3 days) X-ray irradiation in rats. Pilocarpine hydrochloride was administered or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e5c06115b5b4c4e092ec60ad936205
https://doi.org/10.1046/j.1440-1681.2001.03485.x

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Asymmetric synthesis of tricyclic-cyclobutane by means of enantioselective deprotonation and intramolecular Michael–aldol reaction

Autor: Keiko Misawa, Kiyosei Takasu, Masataka Ihara

Publikováno v: Tetrahedron Letters. 42:8489-8491

We have demonstrated the syntheses of enantiomerically enriched tricyclo[4.2.1.03,8]nonanes from Cs symmetric cyclohexanones by means of enantioselective deprotonation, followed by an intramolecular Michael–aldol reaction. The asymmetric deprotonat

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https://doi.org/10.1016/s0040-4039(01)01817-2

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[Case of chronic type C hepatitis complicated with idiopathic thrombocytopenic purpura that was successfully treated by interferon therapy]

Autor: Tetsuru, Karasawa, Hitoshi, Togashi, Katsushi, Tajima, Akihiko, Suzuki, Shigeru, Onodera, Hiroaki, Haga, Rika, Ishii, Keiko, Misawa, Mai, Sanjo, Kazuo, Okumoto, Yuko, Nishise, Junitsu, Ito, Kazuhiko, Sugahara, Koji, Saito, Takafumi, Saito, Sumio, Kawata

Publikováno v: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology. 106(3)

We report a case of chronic hepatitis C complicated with idiopathic thrombocytopenic purpura (ITP), successfully treated with interferon (IFN) beta. A 65-year-old woman was admitted to our hospital for the treatment of chronic hepatitis C with IFN be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7e211144a114cb15473dfe5182fae5b1
https://pubmed.ncbi.nlm.nih.gov/19262055

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