Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Keiko Komuro"'
Autor:
Shunsuke Kondo, Yuki Katsuya, Kan Yonemori, Keiko Komuro, Masatoshi Sugeno, Toshio Kawata, Dana Ghiorghiu, Didier Meulendijks, Noboru Yamamoto
Publikováno v:
Cancer Treatment and Research Communications, Vol 39, Iss , Pp 100809- (2024)
Introduction: We aimed to assess the safety, pharmacokinetic profile, and antitumor activity of adavosertib monotherapy in Japanese patients with advanced solid tumors. Materials and methods: This was a single-center, open-label, phase I study with t
Externí odkaz:
https://doaj.org/article/c5e3b71ea3544fcba7e6ccf11b726a69
Autor:
Yuichiro Doki, Makoto Ueno, Chih‐Hung Hsu, Do‐Youn Oh, Keunchil Park, Noboru Yamamoto, Tatsuya Ioka, Hiroki Hara, Manabu Hayama, Masahiro Nii, Keiko Komuro, Mariko Sugimoto, Makoto Tahara
Publikováno v:
Cancer Medicine, Vol 11, Iss 13, Pp 2550-2560 (2022)
Abstract Background Agents targeting the programmed cell death‐1 pathway have demonstrated encouraging activity across multiple solid tumor types. The dose expansion phase of this phase I study evaluated the safety, tolerability, and antitumor acti
Externí odkaz:
https://doaj.org/article/72cee212174440e8a67e123a8cdd7829
Autor:
Daisuke, Shinoda, Hiroyuki, Tsukagoshi, Keiko, Komuro, Daisuke, Yoshida, Toshikazu, Yanaoka, Mariko, Saito, Nobuhiro, Saruki
Publikováno v:
Japanese Journal of Infectious Diseases. 75:530-532
Respiratory infections are common, and the most common causative agent is a virus. Therefore, routine surveillance of respiratory viruses is useful in the case of novel viral diseases such as coronavirus disease 2019 (COVID-19). In this study, to cla
Autor:
Yutaka Fujiwara, Yasuo Takahashi, Morihito Okada, Takumi Kishimoto, Shunsuke Kondo, Koshi Fujikawa, Manabu Hayama, Masatoshi Sugeno, Shinya Ueda, Keiko Komuro, Mark Lanasa, Takashi Nakano
Publikováno v:
Oncologist
Background The primary objective of this phase I, open-label trial was to assess safety and tolerability of tremelimumab monotherapy and combination therapy with durvalumab in Japanese patients with advanced cancer. Tremelimumab is a fully human mono
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39231c03ef97ce344d67716280206415
https://europepmc.org/articles/PMC9438922/
https://europepmc.org/articles/PMC9438922/
Autor:
Masahiro Nii, Toshiyuki Kozuki, Manabu Hayama, Haruo Iguchi, Noboru Yamamoto, Shinya Ueda, Gordana Vlahovic, Yutaka Fujiwara, Mariko Sugimoto, Keiko Komuro
Publikováno v:
Cancer Science
Blockade of programmed cell death ligand-1 with durvalumab has shown efficacy and safety in large, international studies of patients with advanced solid tumors. A phase 1, non-randomized, open-label multicenter study was initiated to evaluate durvalu
Autor:
Makoto Ueno, Manabu Hayama, Do-Youn Oh, Yutaka Fujiwara, Gordana Vlahovic, Keiko Komuro, Jen-Shi Chen, Akinori Asagi, Tatsuya Ioka, Mariko Sugimoto, Masafumi Ikeda, Keunchil Park, Nobumasa Mizuno, Yuichiro Doki, Masahiro Nii
Publikováno v:
Journal of Clinical Oncology. 37:387-387
387 Background: This Phase 1 study (NCT01938612) evaluated D (anti-PD-L1 mAb) and T (anti-CTLA-4 mAb) in Asian pts, in whom optimal dosing of D and T is undetermined. No dose-limiting toxicities were observed, and durable responses were seen in a dos
Publikováno v:
The Journal of antibiotics. 43(11)
The preparation and antitumor effects of 3'-deamino-3'-morpholino derivatives of pirarubicin are described. Di-N-alkylation of pirarubicin with bis(2-iodoethyl)ether gave 3'-morpholino-pirarubicin, which was converted into its 13-tosylhydrazone, 13-d
Autor:
Setsuko Kunimoto, Shunzo Fukatsu, Tsutomu Tsuchiya, Keiko Komuro, Tomio Takeuchi, Chisato Nosaka
Publikováno v:
The Journal of antibiotics. 43(5)
From various new anthracyclines containing fluorine in their sugar moieties, 7-O-(2,6-dideoxy-2-fluoro-alpha-L-talopyranosyl)adriamycinone-14-hemi pimerate (FAD104) has been selected for clinical investigation, because of its excellent antitumor acti
Publikováno v:
Bulletin of the Chemical Society of Japan. 61:2493-2497
1-O-(2-Aminoethyl)-4′-O-demethyl-1-epipodophyllotoxin derivatives were synthesized by a stereoselective BF3-catalyzed coupling of 4′-O-benzyloxycarbonyl-1-epipodophyllotoxin with the corresponding 2-aminoethanol derivatives, and with ethylene gly
Autor:
Tomio Takeuchi, Daishiro Ikeda, Nobuko Wako, Keiko Komuro, Keiichi Ajito, Chisato Nosaka, Shinichi Kondo
Publikováno v:
The Journal of antibiotics. 42(7)
The preparation and biological evaluation of N-salicylidene derivatives of pirarubicin are described. Pirarubicin was treated with various kinds of aryl aldehydes. Most of compounds synthesized here were more active than pirarubicin in vitro. Some of