Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Keiko Ikoma"'
Autor:
Mizuho Niibori, Yasushi Kudo, Takuya Hayakawa, Keiko Ikoma-Seki, Ryosuke Kawamata, Atsushi Sato, Kazue Mizumura
Publikováno v:
Heliyon, Vol 6, Iss 5, Pp e03963- (2020)
Aims: The daily activity of osteoarthritis (OA) patients is limited by chronic pain and central sensitization. Although non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen are the first-line drugs for the treatment of OA-related pain, th
Externí odkaz:
https://doaj.org/article/35e080b0843d4176be67c1a87d36a8b8
Autor:
Keiko Ikoma-Seki, Kanae Nakamura, Satoru Morishita, Tomoji Ono, Keikichi Sugiyama, Hoyoku Nishino, Hisashi Hirano, Michiaki Murakoshi
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141378 (2015)
Lactoferrin (LF) is a multifunctional glycoprotein present in milk. A clinical study showed that enteric-coated bovine LF tablets decrease visceral fat accumulation. Furthermore, animal studies revealed that ingested LF is partially delivered to mese
Externí odkaz:
https://doaj.org/article/e723fa076e604ed9b195329b78cae4b4
Publikováno v:
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology. 118(9)
Capsule endoscopy has revealed that nonsteroidal anti-inflammatory drugs may cause damage not only to the stomach but also to the small intestine, which has become one of the most serious issues in gastroenterology. However, few studies have reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::163129c10568a0a7b5947c638b3152ee
https://pubmed.ncbi.nlm.nih.gov/34511551
https://pubmed.ncbi.nlm.nih.gov/34511551
Autor:
Kazue Mizumura, Keiko Ikoma-Seki, Ryosuke Kawamata, Mizuho Niibori, Atsushi Sato, Takuya Hayakawa, Yasushi Kudo
Publikováno v:
Heliyon, Vol 6, Iss 5, Pp e03963-(2020)
Heliyon
Heliyon
Aims The daily activity of osteoarthritis (OA) patients is limited by chronic pain and central sensitization. Although non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen are the first-line drugs for the treatment of OA-related pain, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a56baab87da889951c25f42590a11f5
https://doi.org/10.1016/j.heliyon.2020.e03963
https://doi.org/10.1016/j.heliyon.2020.e03963
Autor:
Jian Liu, Yu Asano, Satoshi Yamashita, Seiji Takahashi, Toru Nakayama, Takefumi Shimoyama, Tokuzo Nishino, Keiko Ikoma, Yoshihiko Hirose
Publikováno v:
Journal of Bioscience and Bioengineering. 114:391-397
A novel N-acyl-D-amino acid amidohydrolase (DAA) was purified from the cells of a novel species of the genus Microbacterium. The purified enzyme, termed AcyM, was a monomeric protein with an apparent molecular weight of 56,000. It acted on N-acylated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05530d2afc6fb8ca371137d4c92c33e
https://doi.org/10.1016/j.jbiosc.2012.05.015
https://doi.org/10.1016/j.jbiosc.2012.05.015
Autor:
Izumi Kumagai, Ippei Shimomura, Ryutaro Asano, Takeshi Nakanishi, Shintaro Taki, Mitsuo Umetsu, Keiko Ikoma
Publikováno v:
Journal of Biological Chemistry. 286:1812-1818
Diabodies (Dbs) and tandem single-chain variable fragments (taFv) are the most widely used recombinant formats for constructing small bispecific antibodies. However, only a few studies have compared these formats, and none have discussed their bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::785b0926352f432a78ed568ba5a15308
https://doi.org/10.1074/jbc.m110.172957
https://doi.org/10.1074/jbc.m110.172957
Autor:
Yukiko Sone, Takeshi Nakanishi, Mitsuo Umetsu, Ryutaro Asano, Izumi Kumagai, Yu Katayose, Keiko Ikoma, Michiaki Unno, Hiroko Kawaguchi, Shintaro Taki, Toshio Kudo, Hiroki Hayashi
Publikováno v:
Journal of Biological Chemistry. 285:20844-20849
We previously reported the utility for cancer immunotherapy of a humanized bispecific diabody (hEx3) that targets epidermal growth factor receptor and CD3. Here, we used dynamic and static light scattering measurements to show that the multimer fract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b803c1287cf2bc2c1a12023ffe3ee8
https://doi.org/10.1074/jbc.m110.120444
https://doi.org/10.1074/jbc.m110.120444
Autor:
Izumi Kumagai, Ryutaro Asano, Toshio Kudo, Mitsuo Umetsu, Hiroki Hayashi, Keiko Ikoma, Yu Katayose, Yuna Ishiyama, Hiroko Kawaguchi, Takeshi Nakanishi, Michiaki Unno
Publikováno v:
FEBS Journal. 277:477-487
We previously reported the use of a humanized bi-specific diabody that targets epidermal growth factor receptor and CD3 (hEx3-Db) for cancer immunotherapy. Bacterial expression can be used to express small recombinant antibodies on a large scale; how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1290f081cce6111b29740d6372ab4a43
https://doi.org/10.1111/j.1742-4658.2009.07499.x
https://doi.org/10.1111/j.1742-4658.2009.07499.x
Autor:
Toshio Kudo, Yu Katayose, Keiko Ikoma, Hiroki Hayashi, Ryutaro Asano, Michiaki Unno, Takeshi Nakanishi, Yukiko Sone, Mitsuo Umetsu, Izumi Kumagai
Publikováno v:
Protein Engineering Design and Selection. 21:597-603
We report the utility of in vitro refolding in the preparation of monomorphous hEx3 bispecific diabodies with epidermal growth factor receptor and CD3 retargeting from insoluble aggregates in Escherichia coli. Appropriate interaction between cognate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362d0e90ae5cc1ae559c2215802bb694
https://doi.org/10.1093/protein/gzn037
https://doi.org/10.1093/protein/gzn037
Autor:
Hisashi Hirano, Keiko Ikoma-Seki, Michiaki Murakoshi, Kanae Nakamura, Satoru Morishita, Tomoji Ono, Hoyoku Nishino, Keikichi Sugiyama
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 10, p e0141378 (2015)
PLoS ONE, Vol 10, Iss 10, p e0141378 (2015)
Lactoferrin (LF) is a multifunctional glycoprotein present in milk. A clinical study showed that enteric-coated bovine LF tablets decrease visceral fat accumulation. Furthermore, animal studies revealed that ingested LF is partially delivered to mese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37a91242ca809381223e849cb9f26e6
http://europepmc.org/articles/PMC4623961
http://europepmc.org/articles/PMC4623961