Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Keiko Funa"'
Autor:
Julia Izsak, Henrik Seth, Margarita Iljin, Stephan Theiss, Hans Ågren, Keiko Funa, Ludwig Aigner, Eric Hanse, Sebastian Illes
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Lithium salts are used as mood-balancing medication prescribed to patients suffering from neuropsychiatric disorders, such as bipolar disorder and major depressive disorder. Lithium salts cross the blood-brain barrier and reach the brain par
Externí odkaz:
https://doaj.org/article/dfe9a2628cbc46949c5e6716415a69af
Autor:
Julia Izsak, Dzeneta Vizlin-Hodzic, Margarita Iljin, Joakim Strandberg, Janusz Jadasz, Thomas Olsson Bontell, Stephan Theiss, Eric Hanse, Hans Ågren, Keiko Funa, Sebastian Illes
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Persistent neural stem cell (NSC) proliferation is, among others, a hallmark of immaturity in human induced pluripotent stem cell (hiPSC)-based neural models. TGF-β1 is known to regulate NSCs in vivo during embryonic development in rodents. Here we
Externí odkaz:
https://doaj.org/article/66d945539ed34be099807ded70c1bc61
Autor:
Julia Izsak, Henrik Seth, Mats Andersson, Dzeneta Vizlin-Hodzic, Stephan Theiss, Eric Hanse, Hans Ågren, Keiko Funa, Sebastian Illes
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Reproducibly generating human induced pluripotent stem cell-based functional neuronal circuits, solely obtained from single individuals, poses particular challenges to achieve personalized and patient specific functional neuronal in vitro models. A h
Externí odkaz:
https://doaj.org/article/dcf07ab44f4e414398710e2b811e1c71
Autor:
Hiroto Izumi, Keiko Funa
Publikováno v:
Cells, Vol 8, Iss 5, p 390 (2019)
We examine the role of the heterogenous ribonucleoprotein U (hnRNP U) as a G-quadruplex binding protein in human cell lines. Hypothesizing that hnRNP U is associated with telomeres, we investigate what other telomere-related functions it may have. Te
Externí odkaz:
https://doaj.org/article/86d8d7d9d6b4449d853ba5bcf3875889
Autor:
Zhao-jun Zeng, Erik Johansson, Amiko Hayashi, Pavithra L. Chavali, Nina Akrap, Takeshi Yoshida, Kimitoshi Kohno, Hiroto Izumi, Keiko Funa
Publikováno v:
Biology Open, Vol 1, Iss 6, Pp 527-535 (2012)
Summary TLX is known as the orphan nuclear receptor indispensable for maintaining neural stem cells in adult neurogenesis. We report here that neuroblastoma cell lines express high levels of TLX, which further increase in hypoxia to enhance the angio
Externí odkaz:
https://doaj.org/article/9e1d07fdd7ad47bd9c8367ab22d413cb
Autor:
Rebecka Jörnsten, Tobias Abenius, Teresia Kling, Linnéa Schmidt, Erik Johansson, Torbjörn E M Nordling, Bodil Nordlander, Chris Sander, Peter Gennemark, Keiko Funa, Björn Nilsson, Linda Lindahl, Sven Nelander
Publikováno v:
Molecular Systems Biology, Vol 7, Iss 1, Pp 1-17 (2011)
Abstract DNA copy number aberrations (CNAs) are a hallmark of cancer genomes. However, little is known about how such changes affect global gene expression. We develop a modeling framework, EPoC (Endogenous Perturbation analysis of Cancer), to (1) de
Externí odkaz:
https://doaj.org/article/0e2102e73ff54336a2a3f99e692ca074
Autor:
Andrea E. Ballagi, Per Odin, Agneta Othberg-Cederström, Anja Smits, Wei-Ming Duandr, Olle Lindvall, Keiko Funa
Publikováno v:
Cell Transplantation, Vol 3 (1994)
Platelet-derived growth factor (PDGF) has trophic effect on dopaminergic neurons in vitro. We have previously shown dynamic changes in the expression of PDGF in embryonic mesencephalic grafts and surrounding host striatal tissue following intracerebr
Externí odkaz:
https://doaj.org/article/bc4d1dafd4cb4e6e9506c50eeb05989a
Autor:
Anja Smits, Per Odin, Wei-Ming Duan, Patrik Brundin, Håkan Widner, Carl-Henrik Heldin, Olle Lindvall, Keiko Funa
Publikováno v:
Cell Transplantation, Vol 2 (1993)
The expression of platelet-derived growth factor (PDGF) was investigated in the embryonic donor tissue and surrounding host brain before and after intracerebral transplantation in a rat model of Parkinson's disease (PD). Ventral mesencephalic tissue
Externí odkaz:
https://doaj.org/article/10d7e5337f8944539e1443b716c39c0e
Autor:
Keiko Funa, Akira Nakagawara, Hidetaka Uramoto, Toshinori Ozaki, Abtin Moshiri, Daniel Wetterskog
Supplementary Data from Dysregulation of Platelet-Derived Growth Factor β-Receptor Expression by ΔNp73 in Neuroblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d300cece11bc6e79796e9739d3e770f
https://doi.org/10.1158/1541-7786.22518601
https://doi.org/10.1158/1541-7786.22518601
Autor:
Keiko Funa, Akira Nakagawara, Hidetaka Uramoto, Toshinori Ozaki, Abtin Moshiri, Daniel Wetterskog
We have previously characterized how p53 family proteins control the transcriptional regulation of the platelet-derived growth factor β-receptor (PDGFRB) and found that ΔNp73α, acting dominant-negatively to p53 and p73, can upregulate PDGFRB promo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d7f451d32c26fe9d7705cf4ce69318
https://doi.org/10.1158/1541-7786.c.6542017.v1
https://doi.org/10.1158/1541-7786.c.6542017.v1