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Akademický článek

Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)

The PARP inhibitor olaparib is an approved treatment method for women with BRCA1 and BRCA2 mutation associated cancers. Here the authors show that olaparib can contribute to synthetic viability of cells if PARP1 is inhibited before BRCA2 loss.

Externí odkaz: https://doaj.org/article/cf505f822a744ac9ab12008610c61b55

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Akademický článek

HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression.

Autor: Alix Warburton, Catherine J Redmond, Katharine E Dooley, Haiqing Fu, Maura L Gillison, Keiko Akagi, David E Symer, Mirit I Aladjem, Alison A McBride

Publikováno v: PLoS Genetics, Vol 14, Iss 1, p e1007179 (2018)

Integration of human papillomavirus (HPV) genomes into cellular chromatin is common in HPV-associated cancers. Integration is random, and each site is unique depending on how and where the virus integrates. We recently showed that tandemly integrated

Externí odkaz: https://doaj.org/article/2c5f67a370b1458995c9eda5e1cf579d

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Akademický článek

Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell Carcinoma

Autor: Gabriel J. Starrett, Christina Marcelus, Paul G. Cantalupo, Joshua P. Katz, Jingwei Cheng, Keiko Akagi, Manisha Thakuria, Guilherme Rabinowits, Linda C. Wang, David E. Symer, James M. Pipas, Reuben S. Harris, James A. DeCaprio

Publikováno v: mBio, Vol 8, Iss 1 (2017)

ABSTRACT Merkel cell polyomavirus is the primary etiological agent of the aggressive skin cancer Merkel cell carcinoma (MCC). Recent studies have revealed that UV radiation is the primary mechanism for somatic mutagenesis in nonviral forms of MCC. He

Externí odkaz: https://doaj.org/article/897076653c5b47418a7b045c9bff2e0e

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Akademický článek

Sleeping Beauty mouse models identify candidate genes involved in gliomagenesis.

Autor: Irina Vyazunova, Vilena I Maklakova, Samuel Berman, Ishani De, Megan D Steffen, Won Hong, Hayley Lincoln, A Sorana Morrissy, Michael D Taylor, Keiko Akagi, Cameron W Brennan, Fausto J Rodriguez, Lara S Collier

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e113489 (2014)

Genomic studies of human high-grade gliomas have discovered known and candidate tumor drivers. Studies in both cell culture and mouse models have complemented these approaches and have identified additional genes and processes important for gliomagen

Externí odkaz: https://doaj.org/article/cdd9f158e01f4651930f40c8c80dc5b5

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Akademický článek

Correction: Ultra-Rare Mutation in Long-Range Enhancer Predisposes to Thyroid Carcinoma with High Penetrance.

Publikováno v: PLoS ONE, Vol 8, Iss 9 (2013)

Externí odkaz: https://doaj.org/article/50f60afcdc2b4cdcb420e4955ae0fed3

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Akademický článek

Ultra-rare mutation in long-range enhancer predisposes to thyroid carcinoma with high penetrance.

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e61920 (2013)

Thyroid cancer shows high heritability but causative genes remain largely unknown. According to a common hypothesis the genetic predisposition to thyroid cancer is highly heterogeneous; being in part due to many different rare alleles. Here we used l

Externí odkaz: https://doaj.org/article/651e24fe49534fd19638923f21c5f333

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Akademický článek

Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy.

Autor: Utpal P Davé, Keiko Akagi, Rati Tripathi, Susan M Cleveland, Mary A Thompson, Ming Yi, Robert Stephens, James R Downing, Nancy A Jenkins, Neal G Copeland

Publikováno v: PLoS Genetics, Vol 5, Iss 5, p e1000491 (2009)

Five X-linked severe combined immunodeficiency patients (SCID-X1) successfully treated with autologous bone marrow stem cells infected ex vivo with an IL2RG-containing retrovirus subsequently developed T-cell leukemia and four contained insertional m

Externí odkaz: https://doaj.org/article/a5b7392dd5524f7c8d5a9bf7304d5f68

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