Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Keiko, Muguruma"'
Autor:
Atsushi Tamada, Keiko Muguruma
Publikováno v:
IBRO Neuroscience Reports, Vol 16, Iss , Pp 106-117 (2024)
Organoids are 3D cultured tissues derived from stem cells that resemble the structure of living organs. Based on the accumulated knowledge of neural development, neural organoids that recapitulate neural tissue have been created by inducing self-orga
Externí odkaz:
https://doaj.org/article/4d6b78eb441c4dc4a23f7a0365279e50
Autor:
Hajime Ozaki, Hidetaka Suga, Mayu Sakakibara, Mika Soen, Natsuki Miyake, Tsutomu Miwata, Shiori Taga, Takashi Nagai, Mayuko Kano, Kazuki Mitsumoto, Takashi Miyata, Tomoko Kobayashi, Mariko Sugiyama, Takeshi Onoue, Hiroshi Takagi, Daisuke Hagiwara, Shintaro Iwama, Ryoichi Banno, Genzo Iguchi, Yutaka Takahashi, Keiko Muguruma, Haruhisa Inoue, Hiroshi Arima
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Familial neurohypophyseal diabetes insipidus (FNDI) is a degenerative disease of vasopressin (AVP) neurons. Studies in mouse in vivo models indicate that accumulation of mutant AVP prehormone is associated with FNDI pathology. However, study
Externí odkaz:
https://doaj.org/article/94c212da469e43d0977e7e82b9d91bcb
Autor:
Mariko Taniguchi-Ikeda, Michiyo Koyanagi-Aoi, Tatsuo Maruyama, Toru Takaori, Akiko Hosoya, Hiroyuki Tezuka, Shotaro Nagase, Takuma Ishihara, Taisuke Kadoshima, Keiko Muguruma, Keiko Ishigaki, Hidetoshi Sakurai, Akira Mizoguchi, Bennett G. Novitch, Tatsushi Toda, Momoko Watanabe, Takashi Aoi
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103140- (2021)
Summary: Fukuyama congenital muscular dystrophy (FCMD) is a severe, intractable genetic disease that affects the skeletal muscle, eyes, and brain and is attributed to a defect in alpha dystroglycan (αDG) O-mannosyl glycosylation. We previously estab
Externí odkaz:
https://doaj.org/article/9e0187a4344d489cb9ee7920e4ea9915
Autor:
Toshiya, Kimura, Keiko, Muguruma
Publikováno v:
Folia Pharmacologica Japonica. 158:57-63
Neurological diseases are often life threatening, with severely affecting an individual's quality of life. However, the disease mechanisms are still less understood, mainly because of lacking good disease models. Over the past decades, researchers de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac88dde8d4dc7e80984718c269c18fe
https://doi.org/10.1254/fpj.22084
https://doi.org/10.1254/fpj.22084
Autor:
Kazuma Kamata, Yuki Otsuka, Keiko Imamura, Akio Oishi, Takayuki Kondo, Mika Suga, Ran Shibukawa, Yasue Okanishi, Yukako Sagara, Kayko Tsukita, Tsutomu Yasukawa, Hideaki Usui, Keiko Muguruma, Akitaka Tsujikawa, Haruhisa Inoue
Publikováno v:
Stem Cell Research, Vol 45, Iss , Pp - (2020)
Age-related macular degeneration (AMD) is a late-onset progressive blinding disease. We established human induced pluripotent stem cells (iPSCs) from an AMD patient. The generated iPSC line showed pluripotency markers and three-germ layer differentia
Externí odkaz:
https://doaj.org/article/95ec462bcc61411989499b094634ed32
Autor:
Kazuma Kamata, Yuki Otsuka, Keiko Imamura, Akio Oishi, Takayuki Kondo, Mika Suga, Ran Shibukawa, Yasue Okanishi, Yukako Sagara, Kayko Tsukita, Tsutomu Yasukawa, Hideaki Usui, Keiko Muguruma, Akitaka Tsujikawa, Haruhisa Inoue
Publikováno v:
Stem Cell Research, Vol 45, Iss , Pp - (2020)
Best Disease is an inherited retinal dystrophy that results in progressive and irreversible central vision loss caused by mutations of BESTROPHIN1 (BEST1). We established human induced pluripotent stem cells (iPSCs) from a Best disease patient with m
Externí odkaz:
https://doaj.org/article/c1478b2fb27a4411b947a9e0ff7651d8
Autor:
Yoshihito Ishida, Hideshi Kawakami, Hiroyuki Kitajima, Ayaka Nishiyama, Yoshiki Sasai, Haruhisa Inoue, Keiko Muguruma
Publikováno v:
Cell Reports, Vol 17, Iss 6, Pp 1482-1490 (2016)
Spinocerebellar ataxia type 6 (SCA6) is a dominantly inherited neurodegenerative disease characterized by loss of Purkinje cells in the cerebellum. SCA6 is caused by CAG trinucleotide repeat expansion in CACNA1A, which encodes Cav2.1, α1A subunit of
Externí odkaz:
https://doaj.org/article/2fde6dc2aea94fb6b00ac3eea83a2817
Publikováno v:
Cell Reports, Vol 10, Iss 4, Pp 537-550 (2015)
During cerebellar development, the main portion of the cerebellar plate neuroepithelium gives birth to Purkinje cells and interneurons, whereas the rhombic lip, the germinal zone at its dorsal edge, generates granule cells and cerebellar nuclei neuro
Externí odkaz:
https://doaj.org/article/6d94a10d29af434a968ddd84845ea100
Autor:
Hajime Ozaki, Hidetaka Suga, Mayu Sakakibara, Mika Soen, Natsuki Miyake, Tsutomu Miwata, Shiori Taga, Takashi Nagai, Mayuko Kano, Kazuki Mitsumoto, Takashi Miyata, Tomoko Kobayashi, Mariko Sugiyama, Takeshi Onoue, Hiroshi Takagi, Daisuke Hagiwara, Shintaro Iwama, Ryoichi Banno, Genzo Iguchi, Yutaka Takahashi, Keiko Muguruma, Haruhisa Inoue, Hiroshi Arima
Familial neurohypophyseal diabetes insipidus (FNDI) is a degenerative disease of vasopressin (AVP) neurons. Studies in mouse in vivo models indicate that accumulation of mutant AVP prehormone is associated with FNDI pathology. However, studying human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45d560b096eb0442e5191959623785e9
https://doi.org/10.21203/rs.3.rs-1202298/v1
https://doi.org/10.21203/rs.3.rs-1202298/v1
Autor:
Hidetaka Suga, Hironori Bando, Wataru Ogawa, Genzo Iguchi, Satoshi Narumi, Takashi Aoi, Tomonobu Hasegawa, Hidenori Fukuoka, Keiko Muguruma, Yutaka Takahashi, Ryusaku Matsumoto
Publikováno v:
J Clin Invest
Pituitary develops from oral ectoderm in contact with adjacent ventral hypothalamus. Impairment in this process results in congenital pituitary hypoplasia (CPH); however, there have been no human disease models for CPH thus far, prohibiting the eluci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e199f6f8bc7af882afd602eaafef0fe4
https://doi.org/10.1172/jci127378
https://doi.org/10.1172/jci127378