Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Keiki Sato"'
Autor:
Keiki Sato, Yasuyoshi Kawato, Hirofumi Terasawa, Y. Hirota, Kouichi Uoto, Satoru Ohsuki, Masamichi Sugimori, Ikuo Mitsui, Akio Ejima
Publikováno v:
Journal of Medicinal Chemistry. 41:2308-2318
Nineteen ring A- and F-modified hexacyclic analogues of camptothecin were synthesized by Friedländer condensation of appropriately substituted bicyclic amino ketones with tricyclic ketone and were evaluated for cytotoxicity and topoisomerase I inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0086e00c4f0cd440a5d654de0cee6be3
https://doi.org/10.1021/jm970765q
https://doi.org/10.1021/jm970765q
Autor:
Masamichi Sugimori, Satoru Ohsuki, Yasuhide Hirota, Eiji Kumazawa, Masashi Aonuma, Kouichi Uoto, Hirofumi Terasawa, Akio Ejima, Ikuo Mitsui, Keiki Sato
Publikováno v:
Japanese Journal of Cancer Research : Gann
CPT‐11, a semisynthetic derivative of camptothecin, exhibited strong antitumor activity against lymphoma, lung cancer, colorectal cancer, gastric cancer, ovarian cancer, and cervical cancer. CPT‐11 is a pro‐drug that is converted to an active m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0deebf591f2521e13b34c6191e4d7992
https://doi.org/10.1111/j.1349-7006.1995.tb02468.x
https://doi.org/10.1111/j.1349-7006.1995.tb02468.x
Autor:
Hiroaki Tagawa, Akio Ejima, Ikuo Mitsui, K Matsumoto, M Yasuoka, Satoru Ohsuki, Masamichi Sugimori, Keiki Sato, Yasuyoshi Kawato, Kouichi Uoto
Publikováno v:
Journal of Medicinal Chemistry. 37:3033-3039
Eleven novel hexacyclic and three 7,9-disubstituted pentacyclic derivatives of camptothecin were synthesized and evaluated for in vitro cytotoxic activity against P388, HOC-21, and QG-56 and in vivo antileukemic activity against P388 in mice. Hexacyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::313d1d7c7e7d812a76dab192bbc37aa7
https://doi.org/10.1021/jm00045a007
https://doi.org/10.1021/jm00045a007
Autor:
Kintomo Takakura, Youji Uemae, Takashi Maruyama, Tomokatsu Hori, Yoshikazu Okada, Tadao Ohno, Naohito Yamaguchi, Hiroshi Iseki, Keiki Sato, Akira Matsumura, Katsunori Shimada, Koji Tsuboi, Masao Matsutani, Masahiko Tanaka, Katsuyuki Karasawa, Yoichi Nakazato, Takashi Yamamoto, Yoshihiro Muragaki, Chie Shinohara
Publikováno v:
Journal of neurosurgery. 115(2)
Object The objective of the present study was analysis of results of the prospective clinical trial directed toward the evaluation of therapeutic efficacy of the administration of autologous formalin-fixed tumor vaccine (AFTV) concomitant with fracti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6016cd2448e6558699e8ed1a0b642af
https://pubmed.ncbi.nlm.nih.gov/21568655
https://pubmed.ncbi.nlm.nih.gov/21568655
Autor:
Nobuhiro Ishihara, Akio Ejima, Kazuo Uenakai, Kaho Nakagawa, Hiroshi Kuga, Ikuo Mitsui, Fumio Saito, Keiki Sato
Publikováno v:
Journal of the agricultural chemical society of Japan. 67:1411-1416
コーンの水抽出物中から得られたケトール型不飽和脂肪酸の抗腫瘍活性の評価を行い以下の結果を得た. (1) In vitro試験の結果γ-ケトールはリノール酸に比べ5～10倍の活性を示し,抗腫瘍ス
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1ce8e7d57e68402c50ef5fdefcabf3a
https://doi.org/10.1271/nogeikagaku1924.67.1411
https://doi.org/10.1271/nogeikagaku1924.67.1411
Autor:
Yasuyoshi Kawato, Y. Hirota, Satoru Ohsuki, Akio Ejima, Ikuo Mitsui, Keiki Sato, Masamichi Sugimori, Hirofumi Terasawa, Kouichi Uoto
Publikováno v:
ChemInform. 29
Nineteen ring A- and F-modified hexacyclic analogues of camptothecin were synthesized by Friedlander condensation of appropriately substituted bicyclic amino ketones with tricyclic ketone and were evaluated for cytotoxicity and topoisomerase I inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a226d54667ff7ff5c46d15a1b7cc94a
https://doi.org/10.1002/chin.199842245
https://doi.org/10.1002/chin.199842245
Publikováno v:
Biochemical and Biophysical Research Communications. 188:70-77
In the course of our study to determine the cross-sensitivity between CPT-11 and its active metabolite, SN-38, we found a SN-38-resistant human pancreatic tumor cell line, QGP-1N, which shows sensitivity to CPT-11. The IC50 of SN-38 was 152 times gre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09747fb0facf64118d4ec64f6216ef09
https://doi.org/10.1016/0006-291x(92)92351-w
https://doi.org/10.1016/0006-291x(92)92351-w
Publikováno v:
Drug Metabolism and Pharmacokinetics. 6:899-907
It is known that SN-38, a main metabolite of the novel camptothecin derivative CPT-11, shows a more potent anti-proliferative effect than CPT-11, in vitro. Therefore, it is presumed that SN-38 greatly influences the antitumor effect of CPT-11. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de6898c0233e7ab042d7a56245474563
https://doi.org/10.2133/dmpk.6.899
https://doi.org/10.2133/dmpk.6.899
Autor:
Kazuo Uenakai, Nobuhiro Ishihara, Akio Ejima, Fumio Saito, Hiroshi Kuga, Keiki Sato, Ikuo Mitui, Kaho Fukuda
Publikováno v:
Bioscience, biotechnology, and biochemistry. 57(6)
(1993). Isolation and Characterization of Cytotoxic Compounds from Corn. Bioscience, Biotechnology, and Biochemistry: Vol. 57, No. 6, pp. 1020-1021.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08fc6a89e69414b7aa366730051794cb
https://pubmed.ncbi.nlm.nih.gov/7763870
https://pubmed.ncbi.nlm.nih.gov/7763870
Publikováno v:
Biochemical and biophysical research communications. 184(2)
RNA PCR quantitation method was developed to determine DNA Topoisomerase I(Topo I)-specific mRNA in order to study its gene expression in CPT-11 sensitive, acquired- or native-resistant human pancreatic tumor cell lines. The results were supported by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c60603e3e6b36c5e977c4f1bec2e98
https://pubmed.ncbi.nlm.nih.gov/1315526
https://pubmed.ncbi.nlm.nih.gov/1315526