Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Keijo, Fukushima"'
Publikováno v:
FEBS Open Bio, Vol 12, Iss 4, Pp 775-783 (2022)
EP2 and EP4 prostanoid receptors have long been considered to have similar roles, since they are known to couple with Gαs‐protein and activate cAMP‐mediated signaling pathways. In this study, we re‐evaluated the results of cAMP assays with or
Externí odkaz:
https://doaj.org/article/a79c29d70feb4edab4f9c5e3620c8d8f
Autor:
Motofumi Suzuki, Atsumi Urabe, Sayaka Sasaki, Ryo Tsugawa, Satoshi Nishio, Haruka Mukaiyama, Yoshiko Murata, Hiroshi Masuda, May Sann Aung, Akane Mera, Masaki Takeuchi, Keijo Fukushima, Michika Kanaki, Kaori Kobayashi, Yuichi Chiba, Binod Babu Shrestha, Hiromi Nakanishi, Takehiro Watanabe, Atsushi Nakayama, Hiromichi Fujino, Takanori Kobayashi, Keiji Tanino, Naoko K. Nishizawa, Kosuke Namba
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Iron is an essential plant nutrient that is poorly bioavailable in alkaline soils, resulting in reduced agricultural productivity. Here, the authors report the synthesis of stable and cheap iron-chelator, proline-2’-deoxymugineic acid (PDMA), and d
Externí odkaz:
https://doaj.org/article/a0356333386f4032af1ece59c5ace81c
Autor:
Yoshito Zamami, Takahiro Niimura, Takehiro Kawashiri, Mitsuhiro Goda, Yutaro Naito, Keijo Fukushima, Soichiro Ushio, Fuka Aizawa, Hirofumi Hamano, Naoto Okada, Kenta Yagi, Koji Miyata, Kenshi Takechi, Masayuki Chuma, Toshihiro Koyama, Daisuke Kobayashi, Takao Shimazoe, Hiromichi Fujino, Yuki Izawa-Ishizawa, Keisuke Ishizawa
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 148, Iss , Pp 112744- (2022)
Background: Drug repositioning is a cost-effective method to identify novel disease indications for approved drugs; it requires a shorter developmental period than conventional drug discovery methods. We aimed to identify prophylactic drugs for oxali
Externí odkaz:
https://doaj.org/article/9116b3da1459499098ccab548770cf54
Autor:
Masato Mashimo, Asuka Shimizu, Aimi Mori, Ayaka Hamaguchi, Keijo Fukushima, Naofumi Seira, Takeshi Fujii, Hiromichi Fujino
Publikováno v:
Biochemical and Biophysical Research Communications. 623:133-139
E type prostanoid 4 (EP4) receptors and their signaling pathways have been implicated in the development and malignant transformation of colorectal cancer. We herein demonstrated that the mono(ADP-ribosyl)ation of histone deacetylase (HDAC)1 and HDAC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec41cc08f1f74a080e1ab9740042d178
https://doi.org/10.1016/j.bbrc.2022.07.055
https://doi.org/10.1016/j.bbrc.2022.07.055
Autor:
Keijo, Fukushima, Hiromichi, Fujino
Publikováno v:
Biological and Pharmaceutical Bulletin. 45:698-702
Colorectal cancer (CRC) is one of the common types of cancer in humans. Prostaglandin E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::378b699201ad97847d8bbfe2ca669063
https://doi.org/10.1248/bpb.b22-00104
https://doi.org/10.1248/bpb.b22-00104
Autor:
Natsuki, Yamagiwa, Haruka, Kobayashi, Haruka, Okabayashi, Miki, Yasuda, Keijo, Fukushima, Jun, Kawamura, Satoshi, Kotoura, Hiromichi, Fujino
Publikováno v:
Biological and Pharmaceutical Bulletin. 45:643-648
Plasmalogens are a group of glycerophospholipids containing a vinyl-ether bond at the sn-1 position in the glycerol backbone. Cellular membrane plasmalogens are considered to have important roles in homeostasis as endogenous antioxidants, differentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32224f3c933dfcfadbecd8cafa8c74ca
https://doi.org/10.1248/bpb.b22-00035
https://doi.org/10.1248/bpb.b22-00035
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2556
Human parainfluenza virus type 1 (hPIV1) and type 3 (hPIV3) are respiratory pathogen viruses that bind to terminal sialic acids of glycoconjugates on the cell surface hemagglutinin-neuraminidase glycoprotein. Sialic acid residues are linked to the ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ab63394c94abacc0b12e1ca7cf9bee3b
https://pubmed.ncbi.nlm.nih.gov/36175634
https://pubmed.ncbi.nlm.nih.gov/36175634
Autor:
Takahiro Niimura, Mitsuhiro Goda, Michiko Yamashita, Koichiro Tsuchiya, Keisuke Ishizawa, Hiromichi Fujino, Yasumasa Ikeda, Seiji Kishi, Toshiaki Tamaki, Masaki Imanishi, Hirofumi Hamano, Yoshito Zamami, Yuki Izawa-Ishizawa, Kenshi Takechi, Ken-ichi Aihara, Licht Miyamoto, Yuya Horinouchi, Masayuki Chuma, Keijo Fukushima
Publikováno v:
Kidney International. 99:885-899
Cisplatin is widely used as an anti-tumor drug for the treatment of solid tumors. Unfortunately, it causes kidney toxicity as a critical side effect, limiting its use, given that no preventive drug against cisplatin-induced kidney toxicity is current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f8dd778835cb7f0f23449f5bc6dc9a
https://doi.org/10.1016/j.kint.2020.10.041
https://doi.org/10.1016/j.kint.2020.10.041
Autor:
Yutaka Tamura, John W. Regan, Keijo Fukushima, Toshihiko Murayama, Masato Mashimo, Akiko Suganami, Kanaho Senoo, Nanae Hasuoka, Iori Okura, Hiromichi Fujino
Publikováno v:
Pharmacological Reports. 73:946-953
Human DP and EP2 receptors are two of the most homologically related receptors coupling with Gαs-protein, which stimulate adenylyl cyclase to produce cAMP. Indeed, both receptors are considered to be generated by tandem duplication. It has been repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::151a3ed820ae80370cbce562518cbdda
https://doi.org/10.1007/s43440-021-00247-x
https://doi.org/10.1007/s43440-021-00247-x
Autor:
Yuya Horinouchi, Yuka Murashima, Yuto Yamada, Shun Yoshioka, Keijo Fukushima, Takumi Kure, Naofumi Sasaki, Masaki Imanishi, Hiromichi Fujino, Koichiro Tsuchiya, Kazuaki Shinomiya, Yasumasa Ikeda
Publikováno v:
Life Sciences. 321:121590
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f5869567cbfd199f7f170d49402654d
https://doi.org/10.1016/j.lfs.2023.121590
https://doi.org/10.1016/j.lfs.2023.121590