Výsledky vyhledávání - "Keiji Yamagami"

Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors

Publikováno v: Bioorganicmedicinal chemistry letters. 27(16)

We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 2-phenylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in pot

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https://pubmed.ncbi.nlm.nih.gov/28712708

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2-(2-Phenylmorpholin-4-yl)pyrimidin-4(3H)-ones; A new class of potent, selective and orally active glycogen synthase kinase-3β inhibitors

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 23:6933-6937

A series of 2-(2-phenylmorpholin-4-yl)pyrimidin-4(3H)-ones was synthesized and examined for their inhibitory activity against glycogen synthase kinase-3β (GSK-3β). We found 21, 29 and 30 to possess potent in vitro GSK-3β inhibitory activity with g

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https://doi.org/10.1016/j.bmcl.2013.09.020

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Converging evidence that sequence variations in the novel candidate gene MAP2K7 (MKK7) are functionally associated with schizophrenia

Autor: Brian J. Morris, Robert W. Hunter, Hiromitsu Ohzeki, Catherine L Winchester, John Norrie, Demetrius A. Vouyiouklis, Keiji Yamagami, Josef M. Penninger, Rhiannon Thompson, Judith A. Pratt

Publikováno v: Human Molecular Genetics. 21:4910-4921

Schizophrenia is a debilitating psychiatric disease with a strong genetic contribution, potentially linked to altered glutamatergic function in brain regions such as the prefrontal cortex (PFC). Here, we report converging evidence to support a functi

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https://doi.org/10.1093/hmg/dds331

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Orally Active Neurotrophin-Enhancing Agent Protects Against Dysfunctions of the Peripheral Nerves in Hyperglycemic Animals

Autor: Sumito Sekimoto, Kenichi Saito, Keiji Yamagami, Tetsuya Ohgami, Satoshi Yuki, Bunpei Kakinoki, Mikiko Sejima

Publikováno v: Diabetes. 55:616-621

Biological substances with neurotrophic activities, such as nerve growth factor (NGF) and monosialoganglioside GM1, have been considered as agents for diabetic peripheral neuropathy. Because recent studies have suggested that decreased availability o

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https://doi.org/10.2337/diabetes.55.03.06.db05-1091

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Effects of antipsychotic drugs on neurotoxicity, expression of fos-like protein and c-fos mRNA in the retrosplenial cortex after administration of dizocilpine

Autor: Masatake Fujimura, Keiji Yamagami, Kenji Hashimoto

Publikováno v: European Journal of Pharmacology. 398:1-10

In this study, we examined the effect of clozapine, olanzapine, risperidone and haloperidol on the neuropathology (i.e. neuronal vacuolization) and the expression of Fos-like protein and c-fos mRNA in the retrosplenial cortex of female Sprague-Dawley

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https://doi.org/10.1016/s0014-2999(00)00235-1

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Association of denervation severity in the dermis with the development of mechanical allodynia and hyperalgesia in a murine model of postherpetic neuralgia

Autor: Tsugunobu Andoh, Maki Gouda, Kenta Kagaya, Yasushi Kuraishi, Yuji Inomata, Keiji Yamagami, Atsushi Sasaki

Publikováno v: Anesthesia and analgesia. 116(3)

Postherpetic neuralgia (PHN) is a common complication of herpes zoster and remains a challenging condition of neuropathic pain. Allodynia, a prominent feature of PHN, extends beyond the margins of the initial rash area. In the present study, we inves

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https://pubmed.ncbi.nlm.nih.gov/23400987

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Nucleosides and nucleotides. 155. synthesis, antitumor effects, and possible enzymatic activation mechanism of 5′-phosphatidyl-2′-deoxy-2′-methylenecytidine (DMDC)

Autor: Keiji Yamagami, Akira Matsuda, Satoshi Shuto, Akihiro Fujii, Hirokazu Awano

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:2177-2182

2′-Deoxy-2′-methylenecytidine (DMDC, 1 ) and its 5-fluoro congener (5-F-DMDC, 2 ), potent antitumor nucleosides developed by us, were efficiently converted to their 5′-phosphatidyl derivatives bearing palmitoyl residues ( 3 and 4 , respectively

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https://doi.org/10.1016/0960-894x(96)00389-7

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Syntheses and biological properties of novel aza-podophyllotoxin analogs prossessing pronounced antitumor activity

Autor: Akihiro Fujii, Yukio Hitotsuyanagi, Keiji Yamagami, Tetsuya Tahara, Yukiyasu Ito, Yoichi Naka

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:1039-1042

2,4-Diaza-4-desoxypodophyllotoxin analogs have been synthesized from substituted anilines. Some of them showed promising antitumor activities against vincristine-resistant P388 murine leukemia and B16 melanoma in vivo.

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https://doi.org/10.1016/0960-894x(95)00172-p

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ChemInform Abstract: Synthesis of 2,4-Diaza-4-deoxypodophyllotoxin, a New Analogue of Podophyllotoxin Possessing Antitumour Activity

Autor: Yoichi Naka, Keiji Yamagami, Akihiro Fujii, Tetsuya Tahara, Yukio Hitotsuyanagi

Publikováno v: ChemInform. 26

2,4-Diaza-4-deoxypodophyllotoxin 4 and its cis analogue 14 are synthesised stereoselectively from 3,4-methylenedioxyaniline 5, and show significant activity against vincristine-resistant P-388 leukaemia in vivo.

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https://doi.org/10.1002/chin.199523270

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The effects of aging on muscarinic receptor/G-protein coupling in the rat hippocampus and striatum

Autor: R. Michael Anson, Richelle Cutler, James A. Joseph, George S. Roth, Keiji Yamagami

Publikováno v: Brain Research. 598:302-306

In the striatum and hippocampus, there is a loss of sensitivity to muscarinic agonists with age which has been traced to events early in the signal transduction pathway. Our laboratory has therefore focussed on investigations at this level. The curre

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https://doi.org/10.1016/0006-8993(92)90197-h

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