Zobrazeno 1 - 10
of 533
pro vyhledávání: '"Keiji Wakabayashi"'
Autor:
Takahiro Hamoya, Susumu Tomono, Shingo Miyamoto, Gen Fujii, Keiji Wakabayashi, Michihiro Mutoh
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Aspirin, a nonsteroidal anti-inflammatory drug, has been proven effective in a clinical trial of carcinogenesis blockade. However, various modes of action have been reported for these effects. Thus, in this study, we aimed to present reasona
Externí odkaz:
https://doaj.org/article/fd867acb2a3e4a9886824fdbe99eb5b2
Autor:
Ping Ying Lye, Chika Shiraki, Yuta Fukushima, Keiko Takaki, Mervyn Wing On Liew, Masafumi Yamamoto, Keiji Wakabayashi, Hajime Mori, Eiji Kotani
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108853- (2024)
Summary: Energy reserves, primarily stored in the insect’s fat body, are essential for physiological processes such as reproduction and cocoon formation. However, whether these processes are mutually constraining is unknown. Here, we showed that co
Externí odkaz:
https://doaj.org/article/c31a0e8d4e784f9aa10051a963b366a0
Publikováno v:
Toxins, Vol 16, Iss 8, p 331 (2024)
Pierisin is a DNA-targeting ADP-ribosyltransferase found in cabbage white butterfly (Pieris rapae). Pierisin transfers an ADP-ribosyl moiety to the 2-amino group of the guanine residue in DNA, yielding N2-(ADP-ribos-1-yl)-2′-deoxyguanosine (N2-ADPR
Externí odkaz:
https://doaj.org/article/c5efb7da2679426abe064282b34bee46
Publikováno v:
Toxins, Vol 16, Iss 6, p 270 (2024)
Pierisin-1 was serendipitously discovered as a strong cytotoxic and apoptosis-inducing protein from pupae of the cabbage butterfly Pieris rapae against cancer cell lines. This 98-kDa protein consists of the N-terminal region (27 kDa) and C-terminal r
Externí odkaz:
https://doaj.org/article/9b4c56c50807403d88844b750556d4bb
Autor:
Tao Zhou, Takayuki Ando, Akihiro Kudo, Michio Sato, Noriyuki Miyoshi, Michihiro Mutoh, Hideki Ishikawa, Keiji Wakabayashi, Kenji Watanabe
Publikováno v:
Genes and Environment, Vol 45, Iss 1, Pp 1-7 (2023)
Abstract Background Colibactin is a genotoxin produced by Escherichia coli and other Enterobacteriaceae that is believed to increase the risk of colorectal cancer (CRC) of their symbiosis hosts, including human. A peptidase ClbP is the key enzyme for
Externí odkaz:
https://doaj.org/article/704efcc564b04bcf83a51dce81db4a28
Autor:
Yuta Tsunematsu, Koji Hosomi, Jun Kunisawa, Michio Sato, Noriko Shibuya, Emiko Saito, Haruka Murakami, Yuko Yoshikawa, Yuji Iwashita, Noriyuki Miyoshi, Michihiro Mutoh, Hideki Ishikawa, Haruhiko Sugimura, Motohiko Miyachi, Keiji Wakabayashi, Kenji Watanabe
Publikováno v:
BMC Microbiology, Vol 21, Iss 1, Pp 1-7 (2021)
Abstract Background The Escherichia coli strain that is known to produce the genotoxic secondary metabolite colibactin is linked to colorectal oncogenesis. Therefore, understanding the properties of such colibactin-positive E. coli and the molecular
Externí odkaz:
https://doaj.org/article/ad0699ae8e25497e8ceae1f4381c0e95
Autor:
Daiki Watanabe, Haruka Murakami, Harumi Ohno, Kumpei Tanisawa, Kana Konishi, Kikue Todoroki-Mori, Yuta Tsunematsu, Michio Sato, Yuji Ogata, Noriyuki Miyoshi, Naoto Kubota, Jun Kunisawa, Keiji Wakabayashi, Tetsuya Kubota, Kenji Watanabe, Motohiko Miyachi
Publikováno v:
BMC Microbiology, Vol 21, Iss 1, Pp 1-12 (2021)
Abstract Background Colibactin-producing Escherichia coli containing polyketide synthase (pks + E. coli) has been shown to be involved in colorectal cancer (CRC) development through gut microbiota analysis in animal models. Stool status has been asso
Externí odkaz:
https://doaj.org/article/2e48af1e61964c5a82e87ff540246cd1
Autor:
Masanobu Kawanishi, Chiaki Shimohara, Yoshimitsu Oda, Yuuta Hisatomi, Yuta Tsunematsu, Michio Sato, Yuichiro Hirayama, Noriyuki Miyoshi, Yuji Iwashita, Yuko Yoshikawa, Haruhiko Sugimura, Michihiro Mutoh, Hideki Ishikawa, Keiji Wakabayashi, Takashi Yagi, Kenji Watanabe
Publikováno v:
Genes and Environment, Vol 42, Iss 1, Pp 1-6 (2020)
Abstract Introduction Colibactin is a small genotoxic molecule produced by enteric bacteria, including certain Escherichia coli (E. coli) strains harbored in the human large intestine. This polyketide-peptide genotoxin is considered to contribute to
Externí odkaz:
https://doaj.org/article/6496a12ac1ae42c187cc8a997a882d99
Autor:
Nobuyuki Yamagishi, Tomoki Yamaguchi, Takahisa Kuga, Masanari Taniguchi, Mohammad Shahriar Khan, Takahiro Matsumoto, Yuya Deguchi, Hiroaki Nagaoka, Keiji Wakabayashi, Tetsushi Watanabe
Publikováno v:
Toxicology Reports, Vol 7, Iss , Pp 859-866 (2020)
Exposure to airborne particulate matter (PM) is related to the increased risk of several diseases, including chronic and allergic rhinitis. We have previously shown that atmospheric endotoxin level was positively associated with the number of emergen
Externí odkaz:
https://doaj.org/article/5872f0166d214ec0be9a9761aa609ba0
Autor:
Junya Fujimaki, Neo Sayama, Shigenobu Shiotani, Takanori Suzuki, Miki Nonaka, Yasuhito Uezono, Mamoru Oyabu, Yasutomi Kamei, Haruo Nukaya, Keiji Wakabayashi, Akihito Morita, Tomoki Sato, Shinji Miura
Publikováno v:
Nutrients, Vol 14, Iss 5, p 1023 (2022)
The steroidal alkaloid tomatidine is an aglycone of α-tomatine, which is abundant in tomato leaves and has several biological activities. Tomatidine has been reported to inhibit the growth of cultured cancer cells in vitro, but its anti-cancer activ
Externí odkaz:
https://doaj.org/article/30be56f6148a4b2eb96bcbbe16b03141