Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Keiji Hirota"'
Autor:
By Yukiko Tokifuji, Hodaka Hayabuchi, Takashi Sasaki, Mariko Hara-Chikuma, Keiji Hirota, Hayato Takahashi, Masayuki Amagai, Akihiko Yoshimura, Shunsuke Chikuma
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108646- (2024)
Summary: IL-17-producing helper T (Th17) cells are long-lived and serve as central effector cells in chronic autoimmune diseases. The underlying mechanisms of Th17 persistence remain unclear. We demonstrated that abatacept, a CD28 antagonist, effecti
Externí odkaz:
https://doaj.org/article/11c4d074d00245569a6675b9a7609b54
Autor:
Yusuke Takeuchi, Daiya Ohara, Hitomi Watanabe, Noriko Sakaguchi, Shimon Sakaguchi, Gen Kondoh, Akio Morinobu, Tsuneyo Mimori, Keiji Hirota
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Programmed necrosis, such as necroptosis and pyroptosis, is a highly pro-inflammatory cellular event that is associated with chronic inflammation. Although there are various triggers of pyroptosis and necroptosis in autoimmune tissue inflamm
Externí odkaz:
https://doaj.org/article/cb03ee5c22bb4c15b64ef71023e4d277
Autor:
Miki Arai Hojo, Kyoko Masuda, Hiroaki Hojo, Yosuke Nagahata, Keiko Yasuda, Daiya Ohara, Yusuke Takeuchi, Keiji Hirota, Yutaka Suzuki, Hiroshi Kawamoto, Shinpei Kawaoka
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Autoreactive T cells are deleted in the thymus via thymic negative selection and Bim-mediated apoptosis. Here the authors identify a cis-acting enhancer, E BAB , that is essential for proper Bim expression and apoptosis induction, and show that E BAB
Externí odkaz:
https://doaj.org/article/a59967540154488a8bba0887e70baf97
Autor:
Keiko Yasuda, Yohko Kitagawa, Ryoji Kawakami, Yoshitaka Isaka, Hitomi Watanabe, Gen Kondoh, Terumi Kohwi-Shigematsu, Shimon Sakaguchi, Keiji Hirota
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
A chromatin remodelling factor Satb1 is essential for T cell lineage development in the thymus. Here the authors show that while Satb1 is dispensable for the differentiation of Th17 cells and their response to gut commensals, it plays a critical role
Externí odkaz:
https://doaj.org/article/ee8dcdc2a13e4bc2b13dd9a6f3c601fd
Autor:
Yoshinobu Ikeno, Daiya Ohara, Yusuke Takeuchi, Hitomi Watanabe, Gen Kondoh, Kojiro Taura, Shinji Uemoto, Keiji Hirota
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Foxp3+ regulatory T (Treg) cells are pivotal in maintaining immunological self-tolerance and tissue homeostasis; however, it remains unclear how tissue Treg cells respond to liver injury and regulate chronic inflammation, which can cause liver fibros
Externí odkaz:
https://doaj.org/article/cdaaa4c708534fadb605b83446940435
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
In rheumatoid arthritis (RA), various hematopoietic and non-hematopoietic cells present in the synovial tissue secrete numerous inflammatory mediators including pro-inflammatory cytokines critical for the induction of chronic joint inflammation and b
Externí odkaz:
https://doaj.org/article/afe4de3ed7d54cde9ca62fc3dadc88cc
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79819 (2013)
The aryl hydrocarbon receptor (AhR) has been attributed with anti-inflammatory effects in the development of pathological immune responses leading to experimental autoimmune encephalomyelitis (EAE) via the induction of regulatory T cells. In agreemen
Externí odkaz:
https://doaj.org/article/3fd802c3857143339d437247751e0c6e
Publikováno v:
Biochemical and Biophysical Research Communications. 629:171-175
Melanoma differentiation-associated gene 5 (MDA5) is an essential viral double-stranded RNA sensor to trigger antiviral immune responses, including type I interferon (IFN) induction. Aberrant activation of this viral sensor is known to cause autoimmu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6764188662a70667cec12b599926f9
http://hdl.handle.net/2433/282775
http://hdl.handle.net/2433/282775
Publikováno v:
Pharmaceutical Research. 39:143-152
PurposePulmonary administration of dry drug powder is a considered promising strategy in the treatment of various lung diseases such as tuberculosis and is more effective than systemic medication. However, in the pre-clinical study phase, there is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191dab727db2868499be25913d3d5309
https://doi.org/10.1007/s11095-021-03146-1
https://doi.org/10.1007/s11095-021-03146-1
Autor:
Ryu Watanabe, Keiji Hirota, Sidonia Fagarasan, Koichi Murata, Koichiro Ohmura, Mikako Maruya, Takashi Matsuo, Masao Tanaka, Tsuneyo Mimori, Hajime Yoshifuji, Hiromu Ito, Tatsuaki Tsuruyama, Mirei Shirakashi, Dirk Elewaut, Shimon Sakaguchi, Motomu Hashimoto
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.)REFERENCES. 74(4)
Objective T-cell receptor (TCR) signaling abnormalities and gut dysbiosis are thought to be involved in the development of systemic lupus erythematosus (SLE). However, it is not known whether these mechanisms are interrelated. This study explored the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a773ac416a27ba26abfa0ec2bc0e6a1f
https://pubmed.ncbi.nlm.nih.gov/34725966
https://pubmed.ncbi.nlm.nih.gov/34725966