Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Keiichiro Okuhira"'
Autor:
Sherif E. Emam, Hidenori Ando, Amr S. Abu Lila, Taro Shimizu, Keiichiro Okuhira, Yu Ishima, Mahmoud A. Mahdy, Fakhr-eldin S. Ghazy, Ikuko Sagawa, Tatsuhiro Ishida
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/09da28a66a8c4f9890d08831c8a2ce8b
Autor:
Satoru Sakuma, Kana Yasuda, Risa Kitahara, Kaho Tsujimoto, Kishiko Yamashita, Naohiro Hoshino, Yohko Fujimoto, Keiichiro Okuhira
Publikováno v:
Journal of Nutrition and Metabolism, Vol 2022 (2022)
Sulforaphane and allyl isothiocyanate, naturally occurring isothiocyanates, have been reported to inhibit adipocyte differentiation, but little is known about how they compare in terms of their potency and mechanism of action. In the present study, w
Externí odkaz:
https://doaj.org/article/0e1c1f2ca3ee438380c7c6a8847aba1e
Autor:
Koki Tachibana, Kohshi Kusumoto, Mai Ogawa, Hidenori Ando, Taro Shimizu, Yu Ishima, Tatsuhiro Ishida, Keiichiro Okuhira
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 14617 (2022)
Formation of foam cells as a result of excess lipid accumulation by macrophages is a pathological hallmark of atherosclerosis. Fingolimod (FTY720) is an immunosuppressive agent used in clinical settings for the treatment of multiple sclerosis and has
Externí odkaz:
https://doaj.org/article/7ac0974869a24434842a9ebee823b9e4
Autor:
Ryo Kinoshita, Yu Ishima, Victor T. G. Chuang, Hiroshi Watanabe, Taro Shimizu, Hidenori Ando, Keiichiro Okuhira, Masaki Otagiri, Tatsuhiro Ishida, Toru Maruyama
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1209 (2021)
Human serum albumin (HSA) is a versatile drug carrier with active tumor targeting capacity for an antitumor drug delivery system. Nanoparticle albumin-bound (nab)-technology, such as nab-paclitaxel (Abraxane®), has attracted significant interest in
Externí odkaz:
https://doaj.org/article/f5c75542aa33455685d11e160a9a2435
Autor:
Mayumi Ikeda, Yu Ishima, Victor T. G. Chuang, Maki Sakai, Hiroki Osafune, Hidenori Ando, Taro Shimizu, Keiichiro Okuhira, Hiroshi Watanabe, Toru Maruyama, Masaki Otagiri, Takaaki Akaike, Tatsuhiro Ishida
Publikováno v:
Molecules, Vol 24, Iss 9, p 1689 (2019)
Intracellular polysulfide could regulate the redox balance via its anti-oxidant activity. However, the existence of polysulfide in biological fluids still remains unknown. Recently, we developed a quantitative analytical method for polysulfide and di
Externí odkaz:
https://doaj.org/article/1cff1f8bc5ce4270a3544404929e21cf
Autor:
Satoru Sakuma, Keiichiro Okuhira, Yui Okajima, Ayumi Yoshizumi, Midori Yabuuchi, Yohko Fujimoto
Publikováno v:
Journal of Pharmacy and Nutrition Sciences. 11:65-72
Purpose: Quercetin has been reported as a more potent inhibitor of fat accumulation than other flavonoids. However, little information is available regarding the strength and mechanism of the repressive action of luteolin on fat accumulation. Therefo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7efccf0f82b010ce46ed62fc2cf1e9d
https://doi.org/10.29169/1927-5951.2021.11.09
https://doi.org/10.29169/1927-5951.2021.11.09
Autor:
Keiichiro Okuhira, Masahiro Ueda, Sayuki Arii, Chiaki Komiya, Kohshi Kusumoto, Masaya Denda, Akira Otaka, Akira Shigenaga
Publikováno v:
Chemical and Pharmaceutical Bulletin. 68:1226-1232
Proteins incorporating artificial moieties such as fluorophores and drugs have enjoyed increasing use in chemical biology and drug development research. Preparation of such artificial protein derivatives has relied mainly on native chemical ligation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07fe82bc6bad4245b401156305f4332f
https://doi.org/10.1248/cpb.c20-00674
https://doi.org/10.1248/cpb.c20-00674
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2418
Manipulation of protein stability using small molecules has a great potential for both basic research and clinical therapy. Based on our protein knockdown technology, we developed chimeric degrader molecules SNIPER(ER)s that target the estrogen recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::575337d8f69583bcea61bb962b34c1ef
https://pubmed.ncbi.nlm.nih.gov/35119675
https://pubmed.ncbi.nlm.nih.gov/35119675
Publikováno v:
Methods in Molecular Biology ISBN: 9781071619193
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cc0669b4059c8695f38f84212dc7e91
https://doi.org/10.1007/978-1-0716-1920-9_20
https://doi.org/10.1007/978-1-0716-1920-9_20
Autor:
Keiichiro Okuhira, Mahmoud A. Mahdy, Yu Ishima, Fakhr-eldin S. Ghazy, Tatsuhiro Ishida, Amr S. Abu Lila, Sherif E. Emam, Taro Shimizu, Nehal E. Elsadek, Hidenori Ando
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 145:27-34
Exosomes are gaining increasing attention as drug delivery vehicles due to their low toxicity and ability to functionally transfer biological cargos between cells. However, the therapeutic applicability of exosomes is partially hampered by a lack of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044902de2069ab5b57f7dddb691c126f
https://doi.org/10.1016/j.ejpb.2019.10.005
https://doi.org/10.1016/j.ejpb.2019.10.005