Zobrazeno 1 - 10
of 317
pro vyhledávání: '"Keiichiro, Suzuki"'
Autor:
Fumiyuki Hatanaka, Keiichiro Suzuki, Kensaku Shojima, Jingting Yu, Yuta Takahashi, Akihisa Sakamoto, Javier Prieto, Maxim Shokhirev, Estrella Nuñez Delicado, Concepcion Rodriguez Esteban, Juan Carlos Izpisua Belmonte
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Defect in the SMN1 gene causes spinal muscular atrophy (SMA), which shows loss of motor neurons, muscle weakness and atrophy. While current treatment strategies, including small molecules or viral vectors, have shown promise in improving mot
Externí odkaz:
https://doaj.org/article/10b9828b196546fa8165e5097af9a12a
Autor:
Sho Hagiwara, Tadashi Shiohama, Satoru Takahashi, Masaki Ishikawa, Yusuke Kawashima, Hironori Sato, Daisuke Sawada, Tomoko Uchida, Hideki Uchikawa, Hironobu Kobayashi, Megumi Shiota, Shin Nabatame, Keita Tsujimura, Hiromichi Hamada, Keiichiro Suzuki
Publikováno v:
Biomedicines, Vol 12, Iss 10, p 2172 (2024)
Backgroud: Rett syndrome is a neurodevelopmental disorder that affects 1 in 10,000 females. Various treatments have been explored; however, no effective treatments have been reported to date, except for trofinetide, a synthetic analog of glycine-prol
Externí odkaz:
https://doaj.org/article/b85688b676e941a1bfce11dbfee50f4d
Publikováno v:
Biomolecules, Vol 14, Iss 4, p 506 (2024)
In this study, we introduce electrospun polydioxanone (PDO) nonwoven fabrics as a platform for the delivery of adeno-associated virus (AAV) vectors for transduction and genome editing by adhering them to organ surfaces, including the heart. AAV vecto
Externí odkaz:
https://doaj.org/article/1efe07450ab541adaa83fb7c2c8b1244
Autor:
Baolei Yuan, Xuan Zhou, Keiichiro Suzuki, Gerardo Ramos-Mandujano, Mengge Wang, Muhammad Tehseen, Lorena V. Cortés-Medina, James J. Moresco, Sarah Dunn, Reyna Hernandez-Benitez, Tomoaki Hishida, Na Young Kim, Manal M. Andijani, Chongwei Bi, Manching Ku, Yuta Takahashi, Jinna Xu, Jinsong Qiu, Ling Huang, Christopher Benner, Emi Aizawa, Jing Qu, Guang-Hui Liu, Zhongwei Li, Fei Yi, Yanal Ghosheh, Changwei Shao, Maxim Shokhirev, Patrizia Comoli, Francesco Frassoni, John R. Yates, Xiang-Dong Fu, Concepcion Rodriguez Esteban, Samir Hamdan, Mo Li, Juan Carlos Izpisua Belmonte
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Wiskott-Aldrich syndrome is caused by mutations in WASP, but the underlying mechanisms remain to be explored. Here the authors reveal that WASP deficiency results in aberrant RNA splicing, and that WASP regulates the transcription of splicing factor
Externí odkaz:
https://doaj.org/article/42d4032a62a14197874f6f1fa9c583d6
Autor:
Ryoko Kuwayama, Keiichiro Suzuki, Jun Nakamura, Emi Aizawa, Yoshichika Yoshioka, Masahito Ikawa, Shin Nabatame, Ken-ichi Inoue, Yoshiari Shimmyo, Keiichi Ozono, Taroh Kinoshita, Yoshiko Murakami
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Inherited GPI deficiency (IGD) is caused by PIGO mutations. Here, the authors generate a mouse model of IGD and show that AAV-mediate gene therapy, for knock-in as well as extra-chromosomal expression of Pigo cDNA, ameliorates pathology in the mice.
Externí odkaz:
https://doaj.org/article/279353779621470d85a9bf09f282cfcc
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Proper development and function of the central nervous system require precise regulation of gene expression. MicroRNAs (miRNAs), a group of small non-coding RNAs that can negatively regulate gene expression at the post-transcriptional level, are crit
Externí odkaz:
https://doaj.org/article/2a0ae5a9f74c4f67ba4360eb455b8550
Publikováno v:
Pain Research and Management, Vol 2023 (2023)
Pain management is a major medical issue. However, current medical education in Japan is inadequate with regard to training students to properly assess patients with acute and chronic pain and plan their treatment. Therefore, starting in 2019, Hyogo
Externí odkaz:
https://doaj.org/article/dbe5916b0e4143b0a52d3069da9e9c68
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/4fe2b190d3144fffa63b6934c88b3acb
Autor:
Lan Li, Haruhiko Sakiyama, Hironobu Eguchi, Daisaku Yoshihara, Noriko Fujiwara, Keiichiro Suzuki
Publikováno v:
FEBS Open Bio, Vol 11, Iss 7, Pp 2008-2018 (2021)
The carbohydrate response element‐binding protein (ChREBP), a glucose‐responsive transcription factor that plays a critical role in the glucose‐mediated induction of genes involved in hepatic glycolysis and lipogenesis, exists as two isoforms:
Externí odkaz:
https://doaj.org/article/c1b434e9ebbc49e587ee72619e59ebee
Publikováno v:
ACS Omega, Vol 5, Iss 33, Pp 21254-21259 (2020)
Externí odkaz:
https://doaj.org/article/b335f94783904d9a90a6cedba883dcaf