Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Keiichiro, Matoba"'
Autor:
Keiichiro Matoba, Yosuke Nagai, Kensuke Sekiguchi, Shinji Ohashi, Etsuko Mitsuyoshi, Masayuki Shimoda, Toshiaki Tachibana, Daiji Kawanami, Tamotsu Yokota, Kazunori Utsunomiya, Rimei Nishimura
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Focal segmental glomerulosclerosis (FSGS) shares podocyte damage as an essential pathological finding. Several mechanisms underlying podocyte injury have been proposed, but many important questions remain. Rho-associated, coiled-coil-contain
Externí odkaz:
https://doaj.org/article/2bd38aa5657c4c588e38e29badb7fe47
Autor:
Keiichiro Matoba, Yusuke Takeda, Yosuke Nagai, Kensuke Sekiguchi, Rikako Ukichi, Hiroshi Takahashi, Daisuke Aizawa, Masahiro Ikegami, Toshiaki Tachibana, Daiji Kawanami, Yasushi Kanazawa, Tamotsu Yokota, Kazunori Utsunomiya, Rimei Nishimura
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)
ROCK2 is found to be activated in 3 diabetic models and patients with diabetes. ROCK2 deletion in podocytes protects against diabetic kidney injury, with the beneficial effect of ROCK2 inhibition observed due to rescued PPARα signaling, leading to a
Externí odkaz:
https://doaj.org/article/b37e048bbbbe44a9931bf2345ab6e519
Autor:
David R. Sweet, Neelakantan T. Vasudevan, Liyan Fan, Chloe E. Booth, Komal S. Keerthy, Xudong Liao, Vinesh Vinayachandran, Yoichi Takami, Derin Tugal, Nikunj Sharma, E. Ricky Chan, Lilei Zhang, Yulan Qing, Stanton L. Gerson, Chen Fu, Anthony Wynshaw-Boris, Panjamaporn Sangwung, Lalitha Nayak, Paul Holvoet, Keiichiro Matoba, Yuan Lu, Guangjin Zhou, Mukesh K. Jain
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Inflammation contributes to the development of metabolic disease through incompletely understood mechanisms. Here the authors report that deletion of the transcription factor KLF2 in myeloid cells leads to increased feeding and weight gain in mice wi
Externí odkaz:
https://doaj.org/article/47134c5fedda43b5b639f09776f89f28
Autor:
Keiichiro Matoba, Kensuke Sekiguchi, Yosuke Nagai, Yusuke Takeda, Hiroshi Takahashi, Tamotsu Yokota, Kazunori Utsunomiya, Rimei Nishimura
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine/threonine kinase with essential roles in cytoskeletal functions. Substantial evidence implicates ROCK as a critical regulator in the inception and progression of diabetic nephrop
Externí odkaz:
https://doaj.org/article/8adbfd3744e147d883a9457dcd886bc8
Autor:
Lin Zhou, Stephanie Lapping, Xudong Liao, Yuan Lu, Guangjin Zhou, Keiichiro Matoba, Neelakantan T Vasudevan, Lemin Wang, Lalitha Nayak
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0250139 (2021)
[This corrects the article DOI: 10.1371/journal.pone.0241607.].
Externí odkaz:
https://doaj.org/article/8a9507b93361479982f47852583df3bd
Autor:
Yosuke Nagai, Keiichiro Matoba, Hideji Yako, Shinji Ohashi, Kensuke Sekiguchi, Etsuko Mitsuyoshi, Kazunori Sango, Daiji Kawanami, Kazunori Utsunomiya, Rimei Nishimura
Publikováno v:
Biochemical and Biophysical Research Communications. 649:32-38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39bfe60b8d026348b911186f7d3ff758
https://doi.org/10.1016/j.bbrc.2023.01.088
https://doi.org/10.1016/j.bbrc.2023.01.088
Autor:
Keiichiro Matoba, Yusuke Takeda, Yosuke Nagai, Kensuke Sekiguchi, Tamotsu Yokota, Kazunori Utsunomiya, Rimei Nishimura
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine/threonine kinase that was originally identified as RhoA interacting protein. A diverse array of cellular functions, including migration, proliferation, and phenotypic modulation,
Externí odkaz:
https://doaj.org/article/0c12166862e54da1b3266ddf2e92b935
Autor:
Lin Zhou, Stephanie Lapping, Xudong Liao, Yuan Lu, Guangjin Zhou, Keiichiro Matoba, Neelakantan Vasudevan, Lemin Wang, Lalitha Nayak
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0241607 (2020)
Inflammation is a vital physiological response of the immune system meant to protect against the invasion of pathogens. However, accumulating evidence describes an intimate link between inflammation and thrombosis and cellular elements of the immune
Externí odkaz:
https://doaj.org/article/15d208c625c94555829dcac0e40eb5fc
Autor:
Keiichiro Matoba, Yuan Lu, Rongli Zhang, Eric R. Chen, Panjamaporn Sangwung, Benlian Wang, Domenick A. Prosdocimo, Mukesh K. Jain
Publikováno v:
Cell Reports, Vol 21, Iss 11, Pp 3129-3140 (2017)
Adipose tissue stores energy in the form of triglycerides. The ability to regulate triglyceride synthesis and breakdown based on nutrient status (e.g., fed versus fasted) is critical for physiological homeostasis and dysregulation of this process can
Externí odkaz:
https://doaj.org/article/f66e10a26e51424495b18ca1cad116f1
Autor:
Yosuke Nagai, Keiichiro Matoba, Yusuke Takeda, Hideji Yako, Tomoyo Akamine, Kensuke Sekiguchi, Yasushi Kanazawa, Tamotsu Yokota, Kazunori Sango, Daiji Kawanami, Kazunori Utsunomiya, Rimei Nishimura
Publikováno v:
Kidney International. 102:536-545
Dysregulation of fatty acid utilization is increasingly recognized as a significant component of diabetic kidney disease. Rho-associated, coiled-coil-containing protein kinase (ROCK) is activated in the diabetic kidney, and studies over the past deca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620b7bf415fe01005c94ac81c74037ef
https://doi.org/10.1016/j.kint.2022.04.021
https://doi.org/10.1016/j.kint.2022.04.021