Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Keiichi Tamai"'
Autor:
Shingo Miyabe, Shin Ito, Ikuro Sato, Jiro Abe, Keiichi Tamai, Mai Mochizuki, Haruna Fujimori, Kazunori Yamaguchi, Norihisa Shindo, Hiroshi Shima, Tomoko Yamazaki, Makoto Abue, Yoshinori Okada, Jun Yasuda
Publikováno v:
Thoracic Cancer, Vol 14, Iss 10, Pp 940-952 (2023)
Abstract Background Exposure to environmental carcinogens, such as through smoking, is a major factor in the carcinogenesis of non‐small cell lung cancer (NSCLC). However, genetic factors may also contribute. Methods To identify candidate tumor sup
Externí odkaz:
https://doaj.org/article/f6b04ac76aea4d25b1664d736625be2f
Autor:
Akira Nakazato, Mai Mochizuki, Rie Shibuya-Takahashi, Haruna Fujimori, Keitaro Fujii, Satoshi Saijoh, Shinkichi Morita, Tomoko Yamazaki, Takayuki Imai, Ikuro Sato, Kennichi Satoh, Kazunori Yamaguchi, Kazuo Sugamura, Jun Yasuda, Kazuto Matsuura, Hideo Shojaku, Yukinori Asada, Keiichi Tamai
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract CD271 (also referred to as nerve growth factor receptor or p75NTR) is expressed on cancer stem cells in hypopharyngeal cancer (HPC) and regulates cell proliferation. Because elevated expression of CD271 increases cancer malignancy and correl
Externí odkaz:
https://doaj.org/article/4d23e5b687c8404ca589bd25e53422a8
Autor:
Shigeto Kawai, Kiyotaka Nakano, Keiichi Tamai, Etsuko Fujii, Mimori Yamada, Hiroshi Komoda, Hirofumi Sakumoto, Osamu Natori, Masami Suzuki
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Tumor nests in lung squamous cell carcinoma (LUSC) have a hierarchical structure resembling squamous epithelium. The nests consist of basal-like cells on the periphery and layers of keratinocyte-like cells that differentiate towards the cent
Externí odkaz:
https://doaj.org/article/22b4bc95f3f24ecdb33aebd873a6815e
Autor:
Kazuhiro Kishimoto, Kosuke Kanazawa, Miyuki Nomura, Takuji Tanaka, Taeko Shigemoto‐Kuroda, Katsuya Fukui, Koh Miura, Koreyuki Kurosawa, Masaaki Kawai, Hiroyuki Kato, Keiko Terasaki, Yoshimi Sakamoto, Yoji Yamashita, Ikuro Sato, Nobuhiro Tanuma, Keiichi Tamai, Issay Kitabayashi, Kazuto Matsuura, Toshio Watanabe, Jun Yasuda, Hiroyuki Tsuji, Hiroshi Shima
Publikováno v:
Cancer Medicine, Vol 10, Iss 13, Pp 4451-4464 (2021)
Abstract Background Effective treatments for cancer harboring mutant RAS are lacking. In Drosophila, it was reported that PP6 suppresses tumorigenicity of mutant RAS. However, the information how PP6 regulates oncogenic RAS in mammals is limited. Met
Externí odkaz:
https://doaj.org/article/2186d59ebaa343f3b0924baa94f10c5b
Autor:
Hayato Mizuta, Koutaroh Okada, Mitsugu Araki, Jun Adachi, Ai Takemoto, Justyna Kutkowska, Kohei Maruyama, Noriko Yanagitani, Tomoko Oh-hara, Kana Watanabe, Keiichi Tamai, Luc Friboulet, Kazuhiro Katayama, Biao Ma, Yoko Sasakura, Yukari Sagae, Mutsuko Kukimoto-Niino, Mikako Shirouzu, Satoshi Takagi, Siro Simizu, Makoto Nishio, Yasushi Okuno, Naoya Fujita, Ryohei Katayama
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Resistance to ALK inhibitors such as lorlatinib often arise due to on-target mutations. Here, the authors show the multi-kinase inhibitor gilteritinib is effective against different mutations that arise during lorlatinib in ALK fusion positive lung c
Externí odkaz:
https://doaj.org/article/57a69b4d14e444839652b6a01ced7b32
Autor:
Keiichi Tamai, Mao Nakamura-Shima, Rie Shibuya-Takahashi, Shin-Ichiro Kanno, Akira Yasui, Mai Mochizuki, Wataru Iwai, Yuta Wakui, Makoto Abue, Kuniharu Yamamoto, Koh Miura, Masamichi Mizuma, Michiaki Unno, Sadafumi Kawamura, Ikuro Sato, Jun Yasuda, Kazunori Yamaguchi, Kazuo Sugamura, Kennichi Satoh
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Abstract Cancer stem cells (CSCs) define a subpopulation of cancer cells that are resistant to therapy. However, little is known of how CSC characteristics are regulated. We previously showed that dormant cancer stem cells are enriched with a CD274lo
Externí odkaz:
https://doaj.org/article/46f507a261a544359c2ee01e6ca995c1
Autor:
Shin Ito, Aya Hashimoto, Kazunori Yamaguchi, Sadafumi Kawamura, Shingo Myoen, Maki Ogawa, Ikuro Sato, Takamichi Minato, Shingo Miyabe, Akira Nakazato, Keitaro Fujii, Mai Mochizuki, Haruna Fujimori, Keiichi Tamai, Tetsuya Niihori, Yoko Aoki, Akira Sugawara, Hironobu Sasano, Hiroshi Shima, Jun Yasuda
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 10, Iss 3, Pp n/a-n/a (2022)
Abstract Carney complex (CNC) is a rare hereditary syndrome that involves endocrine dysfunction and the development of various types of tumors. Chromosome 2p16 and PRKAR1A on chromosome 17 are known susceptibility loci for CNC. Here we report a mothe
Externí odkaz:
https://doaj.org/article/5c026882ca754c859701f339f3e86dfd
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
Cancer tissue consists of heterogenous cell types, and cancer stem cells (CSCs) are a subpopulation of the tissue which possess therapy resistance, tumor reconstruction capability, and are responsible for metastasis. Intrahepatic cholangiocarcinoma (
Externí odkaz:
https://doaj.org/article/0f4111e8a1bf48ef95d16d850517f3a6
Autor:
Takamichi Minato, Shin Ito, Bin Li, Haruna Fujimori, Mai Mochizuki, Kazunori Yamaguchi, Keiichi Tamai, Muneaki Shimada, Hideki Tokunaga, Shogo Shigeta, Ikuro Sato, Hiroshi Shima, Hidekazu Yamada, Nobuo Yaegashi, Jun Yasuda
Publikováno v:
Gynecologic Oncology Reports, Vol 38, Iss , Pp 100847- (2021)
Objective: Ovarian cancer (OC) is an intractable gynecological tumor, and frequent recurrence is experienced within a few years even after the complete eradication of tumor tissues by radical resection and neo-adjuvant chemotherapies. The conventiona
Externí odkaz:
https://doaj.org/article/98c121658cd94c0d82306ecc5e1815b2
Autor:
Koutaroh Okada, Mitsugu Araki, Takuya Sakashita, Biao Ma, Ryo Kanada, Noriko Yanagitani, Atsushi Horiike, Sumie Koike, Tomoko Oh-hara, Kana Watanabe, Keiichi Tamai, Makoto Maemondo, Makoto Nishio, Takeshi Ishikawa, Yasushi Okuno, Naoya Fujita, Ryohei Katayama
Publikováno v:
EBioMedicine, Vol 41, Iss , Pp 105-119 (2019)
Background: Alectinib has shown a greater efficacy to ALK-rearranged non-small-cell lung cancers in first-line setting; however, most patients relapse due to acquired resistance, such as secondary mutations in ALK including I1171N and G1202R. Althoug
Externí odkaz:
https://doaj.org/article/3388d031dc2d42b8a7c61b1d850adc34