Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Keiichi Niikura"'
Publikováno v:
Pharmacology Biochemistry and Behavior. 110:112-116
Nonmedical use of the prescription opioid oxycodone has become a major public health problem in the United States, with special concern for adolescents. Although adults and adolescents have different sensitivities for drugs, little is known about the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ede0c3bb84d9d39aa334095e7f8a630a
https://doi.org/10.1016/j.pbb.2013.06.010
https://doi.org/10.1016/j.pbb.2013.06.010
Publikováno v:
Neuroscience. 236:220-232
In heroin-dependent individuals, the drive to avoid or ameliorate the negative affective/emotional state associated with the discontinuation of heroin contributes to the chronic relapsing nature of the disease. Here, we investigate changes in proopio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec271b12587d55e40e4671641a82a91
https://doi.org/10.1016/j.neuroscience.2012.12.071
https://doi.org/10.1016/j.neuroscience.2012.12.071
Autor:
Toshikazu Ushijima, Masaharu Furuya, Satoshi Imai, Hirotaka James Okano, Tsutomu Suzuki, Daiki Okutsu, Kazuo Omi, Michiko Narita, Hideyuki Okano, Minoru Narita, Akira Yamashita, Kazuhiko Miyashita, Atsushi Nakamura, Masaya Nakamura, Akira Kato, Yasuhisa Kobayashi, Keiichi Niikura, Toshikazu Shimizu, Akiko Araki, Hideyuki Takeshima, Daigo Ikegami, Takayuki Ando, Naoko Kuzumaki
Publikováno v:
Brain. 136:828-843
A multiplex analysis for profiling the expression of candidate genes along with epigenetic modification may lead to a better understanding of the complex machinery of neuropathic pain. In the present study, we found that partial sciatic nerve ligatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22eec9289e98840b4de20cdef79516d8
https://doi.org/10.1093/brain/aws330
https://doi.org/10.1093/brain/aws330
Autor:
Kinomi Yomiya, Daiki Okutsu, Megumi Asato, Satoshi Imai, Akira Yamashita, Tsutomu Suzuki, Keiichi Niikura, Naoko Kuzumaki, Yuki Matsushima, Masami Suzuki, Michiko Narita, Yoshi Tsukiyama, Minoru Narita, Motohiro Matoba, Masaharu Furuya, Michiko Konno, Toshikazu Shimizu, Kan Miyoshi, Kana Nanjo-Niikura, Mai Saeki
Publikováno v:
Pain. 152:1358-1372
Insomnia is a common problem for people with chronic pain. Cortical GABAergic neurons are part of the neurobiological substrate that underlies homeostatic sleep regulation. In the present study, we confirmed that sciatic nerve ligation caused thermal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c173f555e521f749bfba0730031f425
https://doi.org/10.1016/j.pain.2011.02.016
https://doi.org/10.1016/j.pain.2011.02.016
Autor:
Mitsuaki Yamazaki, Masaharu Furuya, Emiko Senba, Akira Yamashita, Keiichi Niikura, Noboru Hatakeyama, Yoshi Tsukiyama, Makoto Yanase, Tsutomu Suzuki, Minoru Narita, Motohiro Matoba, Satoshi Imai, Hiroshi Horiuchi, Yoshinori Takemura, Hiroyuki Kinoshita, Naoko Kuzumaki
Publikováno v:
Synapse. 65:668-676
Neuropathic pain is the most difficult pain to manage in the pain clinic, and sleep problems are common among patients with chronic pain including neuropathic pain. In the present study, we tried to visualize the intensity of pain by assessing neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b0b4cfec291c8a4bcabafdf78679d7
https://doi.org/10.1002/syn.20898
https://doi.org/10.1002/syn.20898
Autor:
Keiichi Niikura, Tsutomu Suzuki, Rie Tamura, Daigo Ikegami, Hideyuki Takeshima, Toshikazu Ushijima, Takayuki Ando, Satoshi Imai, Katsuhide Igarashi, Kazuhiro Torigoe, Nana Hareyama, Jun Kanno, Michiko Narita, Minoru Narita, Naoko Kuzumaki
Publikováno v:
Hippocampus. 21:127-132
Environmental enrichment is an experimental paradigm that increases brain-derived neurotrophic factor (BDNF) gene expression accompanied by neurogenesis in the hippocampus of rodents. In the present study, we investigated whether an enriched environm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f04d2338036d1f0d124f71800635d7c
https://doi.org/10.1002/hipo.20775
https://doi.org/10.1002/hipo.20775
Autor:
Tsutomu Suzuki, Kana Kurahashi, Michiko Narita, Minoru Narita, Megumi Asato, Kae Nakahara, Shigemi Takagi, Minako Abe, Kazutaka Ikeda, Keiichi Niikura, Naoko Kuzumaki, Yuki Matsushima, Satoshi Imai, Mai Saeki
Publikováno v:
Addiction Biology. 15:434-447
Despite the importance of prefrontal cortical dopamine in modulating reward, little is known about the implication of the specific subregion of prefrontal cortex in opioid reward. We investigated the role of neurons projecting from the ventral tegmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5682f809bd69df86558044b5afda921a
https://doi.org/10.1111/j.1369-1600.2010.00249.x
https://doi.org/10.1111/j.1369-1600.2010.00249.x
Publikováno v:
Trends in Pharmacological Sciences. 31:299-305
Although morphine and other mu-opioid agonists are the main analgesics for severe pain, these compounds have potential for abuse and/or addiction. This has complicated the use of mu-agonists in the treatment of chronic pain. However, clinical studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef4357ecb4cb60ab56e93687e2b9690
https://doi.org/10.1016/j.tips.2010.04.003
https://doi.org/10.1016/j.tips.2010.04.003
Autor:
Toshikazu Ushijima, Hideyuki Takeshima, Takuya Sasaki, Jun Kanno, Katsuhide Igarashi, Keiichi Niikura, Satoshi Imai, Tsutomu Suzuki, Daigo Ikegami, Rie Tamura, Kazuhiko Miyashita, Michiko Narita, Minoru Narita, Takayuki Ando, Naoko Kuzumaki
Publikováno v:
Synapse. 64:611-616
Recent research has suggested that epigenetic mechanisms, which exert lasting control over gene expression without altering the genetic code, could mediate stable changes in brain function. A growing body of evidence supports the idea that epigenetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a543cd6d4246e1f6f0597f1fe1f31cc9
https://doi.org/10.1002/syn.20768
https://doi.org/10.1002/syn.20768
Autor:
Yoshie Maitani, Michiko Narita, Minoru Narita, Yasuhisa Kobayashi, Toshikazu Shimizu, Masaharu Furuya, Keiichi Niikura, Satoshi Imai, Yasuko Taketa, Masako Iseki, Mitsuaki Yamazaki, Eiichi Inada, Tsutomu Suzuki, Naoko Kuzumaki
Publikováno v:
Anesthesiology. 112:418-431
Background Dynorphin A in the spinal cord is considered to contribute to nociceptive stimuli. However, it has not yet been determined whether activation of the spinal dynorphinergic system under nociceptive stimuli plays a role in direct acceleration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b468d6ec16700a7ca31a60770612285
https://doi.org/10.1097/aln.0b013e3181ca31d9
https://doi.org/10.1097/aln.0b013e3181ca31d9