Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Keiichi Konoki"'
Autor:
Michiru Akamatsu, Ryosuke Hirozumi, Yuko Cho, Yuta Kudo, Keiichi Konoki, Yasukatsu Oshima, Mari Yotsu-Yamashita
Publikováno v:
Marine Drugs, Vol 20, Iss 3, p 166 (2022)
Saxitoxin and its analogues, paralytic shellfish toxins (PSTs), are potent and specific voltage-gated sodium channel blockers. These toxins are produced by some species of freshwater cyanobacteria and marine dinoflagellates. We previously identified
Externí odkaz:
https://doaj.org/article/5c0f1a3144f7460da2afd27e7e77edcc
Publikováno v:
Toxins, Vol 7, Iss 9, Pp 3436-3454 (2015)
Pufferfish poisoning has not been well documented in the South Pacific, although fish and other seafood are sources of protein in these island nations. In this study, tetrodotoxin (TTX) and its analogues in each organ of the pufferfish Arothron hispi
Externí odkaz:
https://doaj.org/article/e319824666b44ed7bd5e306b0ad657e0
Publikováno v:
Marine Drugs, Vol 17, Iss 12, p 653 (2019)
Paralytic shellfish toxins (PSTs) are the major neurotoxic contaminants of edible bivalves in Japan. Tetrodotoxin (TTX) was recently detected in bivalve shellfish around the world, drawing widespread attention. In Japan, high levels of TTX were repor
Externí odkaz:
https://doaj.org/article/5c96ef5f6bdb41ccb8f808aca561a04e
Publikováno v:
Toxins, Vol 11, Iss 9, p 513 (2019)
Brevetoxins are produced by dinoflagellates such as Karenia brevis in warm-water red tides and cause neurotoxic shellfish poisoning. They bind to voltage-gated sodium channels at neurotoxin receptor 5, making the channels more active by shifting the
Externí odkaz:
https://doaj.org/article/affbf8b639ca4f539e9ef2120f956c94
Publikováno v:
Toxins, Vol 11, Iss 9, p 539 (2019)
Saxitoxin (STX) and its analogues, the potent voltage-gated sodium channel blockers, are biosynthesized by freshwater cyanobacteria and marine dinoflagellates. We previously identified several biosynthetic intermediates in the extract of the cyanobac
Externí odkaz:
https://doaj.org/article/aeb6ffbc008340909ad8093de8a19fd0
Autor:
Toshio Nishikawa, Minoru Isobe, Takuya Imazu, Valerie J. Paul, Keiichi Konoki, Yuko Cho, Masaatsu Adachi, Raphael Ritson-Williams, Yuta Kudo, Yuka Abe, Mari Yotsu-Yamashita
Publikováno v:
Marine Drugs, Vol 11, Iss 8, Pp 2799-2813 (2013)
Even though tetrodotoxin (TTX) is a widespread toxin in marine and terrestrial organisms, very little is known about the biosynthetic pathway used to produce it. By describing chemical structures of natural analogs of TTX, we can start to identify so
Externí odkaz:
https://doaj.org/article/cfcf66ce0d0d49239a54f39e4654e0c1
Autor:
Yuko Cho, Keiichi Konoki, Hisatomi Ito, Haruhiko Toyohara, Yi-Chin Lin, Shinya Segawa, Sawako Kondo, Mari Yotsu-Yamashita, Takafumi Uchida
Publikováno v:
Marine Drugs, Vol 11, Iss 1, Pp 165-183 (2013)
Two novel phlorotannins with a molecular weight of 974, temporarily named 974-A and 974-B, were isolated from the polyphenol powder prepared from the edible marine brown alga Ecklonia kurome Okamura, and their chemical structures were determined by s
Externí odkaz:
https://doaj.org/article/e372b829ee7742718222c4e6a4982a57
Publikováno v:
Marine Drugs, Vol 10, Iss 3, Pp 655-667 (2012)
Identification of new tetrodotoxin (TTX) analogs from TTX-possessing animals might provide insight into its biosynthesis and metabolism. In this study, four new analogs, 8-epi-5,6,11-trideoxyTTX, 4,9-anhydro-8-epi-5,6,11-trideoxyTTX, 1-hydroxy-8-epi-
Externí odkaz:
https://doaj.org/article/cc03de308bc14254a67d14f43622af25
Autor:
Yoshikazu Kanai, Sadahiko Hiroki, Hiroyuki Koshino, Keiichi Konoki, Yuko Cho, Mirriam Cayme, Yasuo Fukuyo, Mari Yotsu-Yamashita
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 12, Pp 2245-2254 (2011)
In animals, the product of cyclooxygenase reacting with arachidonic acid, prostaglandin(PG)H2, can undergo spontaneous rearrangement and nonenzymatic ring cleavage to form levuglandin(LG)E2 and LGD2. These LGs and their isomers are highly reactive γ
Externí odkaz:
https://doaj.org/article/234947ba5601474090899595f9d0c8c1
Publikováno v:
Marine Drugs, Vol 16, Iss 7, p 224 (2018)
Pufferfish saxitoxin and tetrodotoxin (TTX) binding protein (PSTBP) is a glycoprotein that we previously isolated from the blood plasma of the pufferfish Takifugu pardalis; this protein was also detected in seven species of the genus Takifugu. We pro
Externí odkaz:
https://doaj.org/article/00186501c93d406295bd11f70ca1cab1