Zobrazeno 1 - 10
of 573
pro vyhledávání: '"Keiichi KAWAI"'
Autor:
Asuka Mizutani, Masato Kobayashi, Kodai Nishi, Ken-ichi Fujita, Kotaro Takahashi, Yuka Muranaka, Kakeru Sato, Masanori Kitamura, Chie Suzuki, Ryuichi Nishii, Naoto Shikano, Yasuhiro Magata, Yasushi Ishida, Munetaka Kunishima, Kazuki Fukuchi, Keiichi Kawai
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: As drug-metabolizing enzyme activities are affected by a variety of factors, such as drug-drug interactions, a method to evaluate drug-metabolizing enzyme activities in real time is needed. In this study, we developed a novel SPECT imagin
Externí odkaz:
https://doaj.org/article/79b4f5f8af464c61a0f3b515bbb3d561
Autor:
Kakeru Sato, Yuka Hirayama, Asuka Mizutani, Jianwei Yao, Jinya Higashino, Yuto Kamitaka, Yuka Muranaka, Kana Yamazaki, Ryuichi Nishii, Masato Kobayashi, Keiichi Kawai
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7747 (2024)
[123I]β-methyl-p-iodophenyl-pentadecanoic acid ([123I]BMIPP), which is used for nuclear medicine imaging of myocardial fatty acid metabolism, accumulates in cancer cells. However, the mechanism of accumulation remains unknown. Therefore, this study
Externí odkaz:
https://doaj.org/article/500ce73f09e64439acffc8ba56d16ee6
Autor:
Yuri Nishiyama, Asuka Mizutani, Masato Kobayashi, Yuka Muranaka, Kakeru Sato, Hideki Maki, Keiichi Kawai
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 656 (2024)
Pseudomonas aeruginosa infection is an infectious disease that must be controlled because it becomes chronic and difficult to treat, owing to its unique system of toxin production/injection and elimination of other bacteria. Here, we noninvasively mo
Externí odkaz:
https://doaj.org/article/bc67d992fd4a4033b0cefcd1d36e9439
Autor:
Kakeru Sato, Tatsuya Seki, Asuka Mizutani, Yuka Muranaka, Shiho Hirota, Kodai Nishi, Kana Yamazaki, Ryuichi Nishii, Takeo Nakanishi, Ikumi Tamai, Keiichi Kawai, Masato Kobayashi
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Chemoradiotherapy is frequently used to treat cancer. Stereotactic body radiotherapy (SBRT) is a single high-dose radiotherapy used to treat a variety of cancers. The anticancer drug methotrexate (MTX) shows affinity for solute carrier (SLC) and ATP-
Externí odkaz:
https://doaj.org/article/2a8f221cabd944009c029eca44e4c498
Autor:
Yuka Muranaka, Miki Matsue, Asuka Mizutani, Masato Kobayashi, Kakeru Sato, Ami Kondo, Yuri Nishiyama, Shusei Ohata, Kodai Nishi, Kana Yamazaki, Ryuichi Nishii, Naoto Shikano, Shigefumi Okamoto, Keiichi Kawai
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4775 (2023)
The World Health Organization has cautioned that antimicrobial resistance (AMR) will be responsible for an estimated 10 million deaths annually by 2050. To facilitate prompt and accurate diagnosis and treatment of infectious disease, we investigated
Externí odkaz:
https://doaj.org/article/f165cbf0b86e4715b5cdbdd5cedf4f04
Autor:
Kakeru Sato, Asuka Mizutani, Yuka Muranaka, Jianwei Yao, Masato Kobayashi, Kana Yamazaki, Ryuichi Nishii, Kodai Nishi, Takeo Nakanishi, Ikumi Tamai, Keiichi Kawai
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 497 (2023)
We evaluated the whole-body distribution of orally-administered radioiodine-125 labeled acetaminophen (125I-AP) to estimate gastrointestinal absorption of anionic drugs. 125I-AP was added to human embryonic kidney (HEK)293 and Flp293 cells expressing
Externí odkaz:
https://doaj.org/article/da3085bf15624b42aa1e36fd55e208bf
Autor:
Asuka Mizutani, Masato Kobayashi, Riku Aibe, Yuka Muranaka, Kodai Nishi, Masanori Kitamura, Chie Suzuki, Ryuichi Nishii, Naoto Shikano, Yasuhiro Magata, Yasushi Ishida, Munetaka Kunishima, Keiichi Kawai
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11458 (2022)
Drug metabolizing enzyme activity is affected by various factors such as drug–drug interactions, and a method to quantify drug metabolizing enzyme activity in real time is needed. In this study, we developed a novel radiopharmaceutical for quantita
Externí odkaz:
https://doaj.org/article/2e3013b9f94347ffbde457974e91891d
Autor:
Yuka Muranaka, Asuka Mizutani, Masato Kobayashi, Koya Nakamoto, Miki Matsue, Fumika Takagi, Kenichi Okazaki, Kodai Nishi, Kana Yamazaki, Ryuichi Nishii, Naoto Shikano, Shigefumi Okamoto, Hideki Maki, Keiichi Kawai
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 1008 (2022)
In this study, we evaluated the use of 15-(4-123I-iodophenyl)-3(R,S)-methylpentadecanoic acid (123I-BMIPP) to visualize fatty acid metabolism in bacteria for bacterial infection imaging. We found that 123I-BMIPP, which is used for fatty acid metaboli
Externí odkaz:
https://doaj.org/article/8f1cbb17a549428799f5fe5ae7bfc748
Autor:
Asuka Mizutani, Masato Kobayashi, Makoto Ohuchi, Keita Sasaki, Yuka Muranaka, Yusuke Torikai, Shota Fukakusa, Chie Suzuki, Ryuichi Nishii, Shunji Haruta, Yasuhiro Magata, Keiichi Kawai
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 1026 (2022)
Single-photon emission computed tomography (SPECT) imaging using intravenous radioactive ligand administration to indirectly evaluate the time-dependent effect of intranasal drugs with poor blood-brain barrier permeability on brain drug distributions
Externí odkaz:
https://doaj.org/article/84ed5d6b296a46f1aa84e558309d40a8
Autor:
Yuka Muranaka, Asuka Mizutani, Masato Kobayashi, Koya Nakamoto, Miki Matsue, Kodai Nishi, Kana Yamazaki, Ryuichi Nishii, Naoto Shikano, Shigefumi Okamoto, Keiichi Kawai
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2467 (2022)
The effectiveness of L- and D-amino acids for detecting the early stage of infection in bacterial imaging was compared. We evaluated the accumulation of 3H-L-methionine (Met), 3H-D-Met, 3H-L-alanine (Ala), and 3H-D-Ala in E. coli EC-14 and HaCaT cell
Externí odkaz:
https://doaj.org/article/8fb8d065b67a465b80009ccc8cc15308