Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Keiichi Izumikawa"'
Autor:
Vivek Singh, Yuzuru Itoh, Samuel Del’Olio, Asem Hassan, Andreas Naschberger, Rasmus Kock Flygaard, Yuko Nobe, Keiichi Izumikawa, Shintaro Aibara, Juni Andréll, Paul C. Whitford, Antoni Barrientos, Masato Taoka, Alexey Amunts
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract The mitoribosome translates mitochondrial mRNAs and regulates energy conversion that is a signature of aerobic life forms. We present a 2.2 Å resolution structure of human mitoribosome together with validated mitoribosomal RNA (rRNA) modifi
Externí odkaz:
https://doaj.org/article/25b459b1c9f4493c81a55c314635cfbf
Autor:
Naohiro Egawa, Yuishin Izumi, Hidefumi Suzuki, Itaru Tsuge, Koji Fujita, Hitoshi Shimano, Keiichi Izumikawa, Nobuhiro Takahashi, Kayoko Tsukita, Takako Enami, Masahiro Nakamura, Akira Watanabe, Motoko Naitoh, Shigehiko Suzuki, Tsuneyoshi Seki, Kazuhiro Kobayashi, Tatsushi Toda, Ryuji Kaji, Ryosuke Takahashi, Haruhisa Inoue
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Dyslipidemia is considered an essential component of the pathological process of amyotrophic lateral sclerosis (ALS), a fatal motor neuron disease. Although TAR DNA Binding Protein 43 kDa (TDP-43) links both familial and sporadic forms of AL
Externí odkaz:
https://doaj.org/article/28b5a033d5004d9786adf1561756bcbc
Autor:
Keiichi Izumikawa, Yuko Nobe, Harunori Yoshikawa, Hideaki Ishikawa, Yutaka Miura, Hiroshi Nakayama, Takashi Nonaka, Masato Hasegawa, Naohiro Egawa, Haruhisa Inoue, Kouki Nishikawa, Koji Yamano, Richard J. Simpson, Masato Taoka, Yoshio Yamauchi, Toshiaki Isobe, Nobuhiro Takahashi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The 43-kDa trans-activating response region DNA-binding protein 43 (TDP-43) is a product of a causative gene for amyotrophic lateral sclerosis (ALS). Despite of accumulating evidence that mitochondrial dysfunction underlies the pathogenesis
Externí odkaz:
https://doaj.org/article/9971d9fd83d945bca18af986cb1ebe25
Autor:
Maoshan Chen, Rong Xu, Alin Rai, Wittaya Suwakulsiri, Keiichi Izumikawa, Hideaki Ishikawa, David W Greening, Nobuhiro Takahashi, Richard J Simpson
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210003 (2019)
Extracellular vesicle (EV) microRNAs are of major interest as potential diagnostic biomarkers in all cancer types. This study aims to identify miRNA profiles of shed microvesicles (sMVs) and exosomes (Exos) secreted from the isogenic colorectal cance
Externí odkaz:
https://doaj.org/article/3810ec18ffcf4cabb63e00b66f2aeefa
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164773 (2016)
Scd6, a yeast homologue of human RAP55, is a component of messenger ribonucleoproteins (mRNPs) that repress translation by binding to translation initiation factors, and also is a decapping activator along with the binding partners Edc3 and Dhh1. Her
Externí odkaz:
https://doaj.org/article/7701de645956409e97cb0093fc96c9ed
Autor:
Vivek Singh, Yuzuru Itoh, Samuel Del'Olio, Asem Hassan, Andreas Naschberger, Rasmus Kock Flygaard, Yuko Nobe, Keiichi Izumikawa, Shintaro Aibara, Juni Andrell, Paul Whitford, Antoni Barrientos, Masato Taoka, Alexey Amunts
The mitoribosome translates mitochondrial mRNAs and regulates energy conversion that is a signature of aerobic life forms. We present a 2.2 Å resolution structure of human mitoribosome together with validated mitoribosomal RNA (rRNA) modifications,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be1efaf31ac006ac97aa3f9e165d32dd
https://doi.org/10.1101/2023.05.24.542018
https://doi.org/10.1101/2023.05.24.542018
Autor:
Toshiaki Isobe, Yoshio Yamauchi, Keiichi Izumikawa, Hideaki Ishikawa, Nobuhiro Takahashi, Harunori Yoshikawa, Sjaak Philipsen, Richard J. Simpson, Yuko Nobe
Publikováno v:
Nucleic Acids Research
Scopus-Elsevier
Scopus-Elsevier
Chtop (chromatin target of Prmt1) regulates various aspects of gene expression including transcription and mRNA export. Despite these important functions, the regulatory mechanism underlying Chtop expression remains undetermined. Using Chtop-expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a366228ec94e7d0fecb2b40f93953ec4
Autor:
Ryuji Kaji, Tatsushi Toda, Keiichi Izumikawa, Takako Enami, Akira Watanabe, Ryosuke Takahashi, Koji Fujita, Kazuhiro Kobayashi, Masahiro Nakamura, Motoko Naitoh, Hitoshi Shimano, Suzuki Shigehiko, Tsuneyoshi Seki, Inoue Haruhisa, Nobuhiro Takahashi, Yuishin Izumi, Kayoko Tsukita, Itaru Tsuge, Naohiro Egawa
Dyslipidemia is correlated with the prognosis of amyotrophic lateral sclerosis (ALS), a fatal motor neuron disorder characterized pathologically by TAR DNA binding protein (TDP-43) inclusions. We investigated molecular mechanisms of lipid metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca94dc584e3da00471ab8b2fbcd2b27a
https://doi.org/10.21203/rs.3.rs-608138/v1
https://doi.org/10.21203/rs.3.rs-608138/v1
Autor:
Yutaka Miura, Toshiya Hayano, Keiichi Izumikawa, Hiroyuki Aburatani, Li Li, Richard J. Simpson, Harunori Yoshikawa, Toshiaki Isobe, Jinrong Min, Sally Fujiyama, Hideaki Ishikawa, Akira Watanabe, Nobuhiro Takahashi, Hiroyuki Tachikawa
Publikováno v:
Nucleic Acids Research
Activation of ribosomal RNA (rRNA) synthesis is pivotal during cell growth and proliferation, but its aberrant upregulation may promote tumorigenesis. Here, we demonstrate that the candidate oncoprotein, LYAR, enhances ribosomal DNA (rDNA) transcript
Autor:
Ko Sato, Keiichi Izumikawa, Toshiaki Isobe, Masato Taoka, Hiroshi Nakayama, Hideaki Ishikawa, Richard J. Simpson, Yoshio Yamauchi, Nobuhiro Takahashi, Yuko Nobe
Publikováno v:
Nucleic Acids Research
TDP-43 regulates cellular levels of Cajal bodies (CBs) that provide platforms for the assembly and RNA modifications of small nuclear ribonucleoproteins (snRNPs) involved in pre-mRNA splicing. Alterations in these snRNPs may be linked to pathogenesis