Zobrazeno 1 - 10
of 258
pro vyhledávání: '"Keiichi HIGUCHI"'
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 35, Iss , Pp 100964- (2023)
In humans, mutations in the coproporphyrinogen oxidase (CPOX) gene can result in hereditary coproporphyria (HCP), characterized by high levels of coproporphyrin excretion in the urine and feces, as well as acute neurovisceral and chronic cutaneous ma
Externí odkaz:
https://doaj.org/article/a5ae1497dc394996897b7c3a7b8558d3
Autor:
Xiaoran Cui, Jinko Sawashita, Jian Dai, Chang Liu, Yuichi Igarashi, Masayuki Mori, Hiroki Miyahara, Keiichi Higuchi
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 3 (2022)
Exercise interventions are beneficial for reducing the risk of age-related diseases, including amyloidosis, but the underlying molecular links remain unclear. Here, we investigated the protective role of interval exercise training in a mouse model of
Externí odkaz:
https://doaj.org/article/f6ed756bb15543a299b4f7d1faedba41
Autor:
Jian Dai, Ying Li, Fuyuki Kametani, Xiaoran Cui, Yuichi Igarashi, Jia Huo, Hiroki Miyahara, Masayuki Mori, Keiichi Higuchi
Publikováno v:
eLife, Vol 10 (2021)
Curcumin is a polyphenol compound that exhibits multiple physiological activities. To elucidate the mechanisms by which curcumin affects systemic amyloidosis, we investigated amyloid deposition and molecular changes in a mouse model of amyloid apolip
Externí odkaz:
https://doaj.org/article/97af2239aea04afcaea7befa7e51461e
Publikováno v:
International Journal of Transportation Science and Technology, Vol 7, Iss 2, Pp 103-113 (2018)
In this study, we define urban safety as two aspects: to against traffic accidents and urban crime. In a general view, Japan has been ranked as one of the least fatalities countries by the traffic safety statistics as well as one of the least crime r
Externí odkaz:
https://doaj.org/article/e9a8357fe7a6443fac6d0758fee12592
Autor:
Zhe Xu, Jia Huo, Xin Ding, Mu Yang, Lin Li, Jian Dai, Kazunori Hosoe, Hiroshi Kubo, Masayuki Mori, Keiichi Higuchi, Jinko Sawashita
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Our recent studies revealed that supplementation with the reduced form of coenzyme Q10 (CoQ10H2) inhibits oxidative stress and slows the process of aging in senescence-accelerated mice. CoQ10H2 inhibits adipocyte differentiation and regulate
Externí odkaz:
https://doaj.org/article/49974e03f7624c79af0f4c84d533cbc8
Publikováno v:
International Journal of Automotive Engineering, Vol 8, Iss 2, Pp 50-54 (2017)
This study investigated the electricity consumption properties of ultra-compact electric vehicles (UCEVs) in the real world. Vehicle running data collected in a social experiment of UCEVs implemented in Kato City, Japan, were used for an empirical st
Externí odkaz:
https://doaj.org/article/d31800922c2e4e2f98e2850662470b1d
Publikováno v:
Journal of Advanced Transportation, Vol 2020 (2020)
In the aging society, reducing vehicle crashes caused by elderly drivers has become a crucial issue. To find effective methods to reduce these vehicle crashes, it is necessary to give some insights into the characteristics of vehicle crashes and thos
Externí odkaz:
https://doaj.org/article/98a76675a7ba494fa6a185463bd9129b
Publikováno v:
Molecules, Vol 19, Iss 8, Pp 12242-12257 (2014)
β-Amyloid (Aβ) is deposited in neurons and vascular cells of the brain and is characterized as a pathologic feature of Alzheimer’s disease (AD). Recently studies have reported that there is an association between cardiovascular risk factors and A
Externí odkaz:
https://doaj.org/article/5c3285e1a71349988987c7e27f85127e
Autor:
Lin Li, Jinko Sawashita, Xin Ding, Mu Yang, Zhe Xu, Hiroki Miyahara, Masayuki Mori, Keiichi Higuchi
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172402 (2017)
In mouse senile amyloidosis, apolipoprotein (Apo) A-II is deposited extracellularly in many organs in the form of amyloid fibrils (AApoAII). Reduction of caloric intake, known as caloric restriction (CR), slows the progress of senescence and age-rela
Externí odkaz:
https://doaj.org/article/3a1a5edb80b9438cbffe94fe2cc334cd
Autor:
Yaoyong Wang (王耀勇), Jinko Sawashita (澤下仁子), Jinze Qian (钱金泽), Beiru Zhang (张蓓茹), Xiaoying Fu (付笑影), Geng Tian (田耕), Lei Chen (陈磊), Masayuki Mori (森 政之), Keiichi Higuchi (樋口京一)
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 8, Pp 1461-1470 (2011)
Apolipoprotein A-II (apoA-II) is the second major apolipoprotein following apolipoprotein A-I (apoA-I) in HDL. ApoA-II has multiple physiological functions and can form senile amyloid fibrils (AApoAII) in mice. Most circulating apoA-II is present in
Externí odkaz:
https://doaj.org/article/753f1584123342fcbf6d4969e89441a2