Zobrazeno 1 - 10
of 528
pro vyhledávání: '"Keiichi Kawai"'
Autor:
Asuka Mizutani, Masato Kobayashi, Kodai Nishi, Ken-ichi Fujita, Kotaro Takahashi, Yuka Muranaka, Kakeru Sato, Masanori Kitamura, Chie Suzuki, Ryuichi Nishii, Naoto Shikano, Yasuhiro Magata, Yasushi Ishida, Munetaka Kunishima, Kazuki Fukuchi, Keiichi Kawai
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: As drug-metabolizing enzyme activities are affected by a variety of factors, such as drug-drug interactions, a method to evaluate drug-metabolizing enzyme activities in real time is needed. In this study, we developed a novel SPECT imagin
Externí odkaz:
https://doaj.org/article/79b4f5f8af464c61a0f3b515bbb3d561
Autor:
Yuri Nishiyama, Asuka Mizutani, Masato Kobayashi, Yuka Muranaka, Kakeru Sato, Hideki Maki, Keiichi Kawai
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 656 (2024)
Pseudomonas aeruginosa infection is an infectious disease that must be controlled because it becomes chronic and difficult to treat, owing to its unique system of toxin production/injection and elimination of other bacteria. Here, we noninvasively mo
Externí odkaz:
https://doaj.org/article/bc67d992fd4a4033b0cefcd1d36e9439
Autor:
Kakeru Sato, Tatsuya Seki, Asuka Mizutani, Yuka Muranaka, Shiho Hirota, Kodai Nishi, Kana Yamazaki, Ryuichi Nishii, Takeo Nakanishi, Ikumi Tamai, Keiichi Kawai, Masato Kobayashi
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Chemoradiotherapy is frequently used to treat cancer. Stereotactic body radiotherapy (SBRT) is a single high-dose radiotherapy used to treat a variety of cancers. The anticancer drug methotrexate (MTX) shows affinity for solute carrier (SLC) and ATP-
Externí odkaz:
https://doaj.org/article/2a8f221cabd944009c029eca44e4c498
Autor:
Kakeru Sato, Asuka Mizutani, Yuka Muranaka, Jianwei Yao, Masato Kobayashi, Kana Yamazaki, Ryuichi Nishii, Kodai Nishi, Takeo Nakanishi, Ikumi Tamai, Keiichi Kawai
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 497 (2023)
We evaluated the whole-body distribution of orally-administered radioiodine-125 labeled acetaminophen (125I-AP) to estimate gastrointestinal absorption of anionic drugs. 125I-AP was added to human embryonic kidney (HEK)293 and Flp293 cells expressing
Externí odkaz:
https://doaj.org/article/da3085bf15624b42aa1e36fd55e208bf
Autor:
Yuka Muranaka, Asuka Mizutani, Masato Kobayashi, Koya Nakamoto, Miki Matsue, Fumika Takagi, Kenichi Okazaki, Kodai Nishi, Kana Yamazaki, Ryuichi Nishii, Naoto Shikano, Shigefumi Okamoto, Hideki Maki, Keiichi Kawai
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 1008 (2022)
In this study, we evaluated the use of 15-(4-123I-iodophenyl)-3(R,S)-methylpentadecanoic acid (123I-BMIPP) to visualize fatty acid metabolism in bacteria for bacterial infection imaging. We found that 123I-BMIPP, which is used for fatty acid metaboli
Externí odkaz:
https://doaj.org/article/8f1cbb17a549428799f5fe5ae7bfc748
Autor:
Asuka Mizutani, Masato Kobayashi, Makoto Ohuchi, Keita Sasaki, Yuka Muranaka, Yusuke Torikai, Shota Fukakusa, Chie Suzuki, Ryuichi Nishii, Shunji Haruta, Yasuhiro Magata, Keiichi Kawai
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 1026 (2022)
Single-photon emission computed tomography (SPECT) imaging using intravenous radioactive ligand administration to indirectly evaluate the time-dependent effect of intranasal drugs with poor blood-brain barrier permeability on brain drug distributions
Externí odkaz:
https://doaj.org/article/84ed5d6b296a46f1aa84e558309d40a8
Publikováno v:
Case Reports in Oncology, Vol 11, Iss 2, Pp 383-387 (2018)
We present a case in which neoadjuvant arterial infusion chemotherapy was effective in treating a large superficial bladder cancer. A 50-year-old male was admitted to the Kanazawa Medical Center with the complaint of dizziness. The patient exhibited
Externí odkaz:
https://doaj.org/article/8e6f036e20844e518c05f1a1294bb67d
Autor:
Masato Kobayashi, Asuka Mizutani, Yuka Muranaka, Kodai Nishi, Hisakazu Komori, Ryuichi Nishii, Naoto Shikano, Takeo Nakanishi, Ikumi Tamai, Keiichi Kawai
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 61 (2021)
Gastrointestinal tract absorption of cationic anticancer drugs and medicines was estimated using whole-body imaging following oral [123I]MIBG administration. [123I]MIBG was added to cultures of human embryonic kidney (HEK)293 cells expressing human o
Externí odkaz:
https://doaj.org/article/bae6afbbab2244dab82add208d3d30cd
Autor:
Kodai Nishi, Masato Kobayashi, Minori Kikuchi, Asuka Mizutani, Yuka Muranaka, Ikumi Tamai, Keiichi Kawai, Takashi Kudo
Publikováno v:
Pharmaceutics, Vol 13, Iss 7, p 1073 (2021)
The accumulation of high levels of 99mTc-tetrofosmin (99mTc-TF) in the hepatobiliary system can lead to imaging artifacts and interference with diagnosis. The present study investigated the transport mechanisms of 99mTc-TF and attempted to apply comp
Externí odkaz:
https://doaj.org/article/4ffa9d556a114c9e85982acf71cd6504
Autor:
Masato Kobayashi, Toshitaka Kato, Kohshin Washiyama, Masaaki Ihara, Asuka Mizutani, Kodai Nishi, Leo G Flores, Ryuichi Nishii, Keiichi Kawai
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0213397 (2019)
BackgroundAlthough a 3-arm DOTA construct, which has three carboxylic acids, h has been applied for conjugation to many peptides, we investigated if a 4-arm DOTA construct conjugated to peptides improves chemical properties for melanoma imaging of th
Externí odkaz:
https://doaj.org/article/1ba7e45020364dda9d75f58540dc78cd