Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Keigo Okada"'
Autor:
Yotaro Motomura, Yoshihiro Umezawa, Tomoyuki Arimatsu, Keigo Okada, Osamu Miura, Takashi Kumagai
Publikováno v:
Clinical Case Reports, Vol 10, Iss 2, Pp n/a-n/a (2022)
Abstract We report a case of fever of unknown origin in a patient with MDS associated with IgM‐MGUS. The patient was positive for MYD88 mutation, and chemotherapy for LPL/WM improved the fever. Analysis of MYD88 and the effect of chemotherapy on LP
Externí odkaz:
https://doaj.org/article/b2245996496b498fae4921a182f63970
Publikováno v:
Translational Oncology, Vol 12, Iss 2, Pp 336-349 (2019)
FLT3-ITD and FLT3-TKD are the most frequent tyrosine kinase mutations in acute myeloid leukemia (AML), with the former conferring a poor prognosis. We have recently revealed that FLT3-ITD confers resistance to the PI3K/AKT pathway inhibitors by prote
Externí odkaz:
https://doaj.org/article/fe836c00a4bc4fe7a6f6be7ebf44d7fd
Autor:
Yuta Izumi, Masashi Kanayama, Zhongchuzi Shen, Masayuki Kai, Shunsuke Kawamura, Megumi Akiyama, Masahide Yamamoto, Toshikage Nagao, Keigo Okada, Norihiko Kawamata, Shigeo Toyota, Toshiaki Ohteki
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
As hematopoietic progenitors supply a large number of blood cells, therapeutic strategies targeting hematopoietic progenitors are potentially beneficial to eliminate unwanted blood cells, such as leukemic cells and immune cells causing diseases. Howe
Externí odkaz:
https://doaj.org/article/89ee7ec717ce43f58f0d4c54e650e90e
Autor:
Hiroki Akiyama, Yoshihiro Umezawa, Daisuke Watanabe, Keigo Okada, Shinya Ishida, Ayako Nogami, Osamu Miura
Publikováno v:
Cancers, Vol 12, Iss 2, p 406 (2020)
JAK2-V617F plays a key role in the pathogenesis of myeloproliferative neoplasm. However, its inhibitor ruxolitinib has shown limited clinical efficacies because of the ruxolitinib-persistent proliferation of JAK2-V617F-positive cells. We here demonst
Externí odkaz:
https://doaj.org/article/fdea05f4995a4988bbb37a8e3bb33229
Publikováno v:
Cancers, Vol 11, Iss 12, p 1827 (2019)
FLT3-ITD is the most frequent tyrosine kinase mutation in acute myeloid leukemia (AML) associated with poor prognosis. We previously found that FLT3-ITD activates the mTORC1/S6K/4EBP1 pathway cooperatively through the STAT5/PIM and PI3K/AKT pathways
Externí odkaz:
https://doaj.org/article/f0458a2812de4b9eb08de31cb571bbc2
Autor:
Manabu, Shoji, Daisuke, Kittaka, Keigo, Okada, Mitsuyoshi, Yasuda, Hiroyuki, Watanabe, Hisaya, Sato, Kyoichi, Kato
Publikováno v:
Japanese Journal of Radiological Technology. 78:502-510
This study aimed to investigate the feasibility of estimating functional ischemia information from coronary artery computed tomography (CACT) data (i.e., morphological information). Fifty-five suspected ischemic heart disease patients were included i
Autor:
Yoshinobu Kanda, Shun-ichi Kimura, Hiroaki Shimizu, Takuya Miyazaki, Masatoshi Sakurai, Susumu Tanoue, Kensuke Kayamori, Chikako Ohwada, Kazuki Yoshimura, Hideki Nakasone, Takuma Ohashi, Katsuhiro Shono, Takayoshi Tachibana, Kaoru Hatano, Keigo Okada, Yuta Kimura, Sachiko Seo, Noriko Doki, Masatsugu Tanaka, Yoshihiro Hatta, Satoshi Takahashi
This study aimed to evaluate the impact of standard-dose dipeptidyl peptidase-4 inhibitors (DPP-4i) on the incidence of graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT). We retrospectively evaluated 207 diabe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6387f5de9b1a039357f0494abdb82218
https://doi.org/10.21203/rs.3.rs-2038009/v1
https://doi.org/10.21203/rs.3.rs-2038009/v1
Autor:
Shun-Ichi, Kimura, Hiroaki, Shimizu, Takuya, Miyazaki, Masatoshi, Sakurai, Susumu, Tanoue, Kensuke, Kayamori, Chikako, Ohwada, Kazuki, Yoshimura, Hideki, Nakasone, Takuma, Ohashi, Katsuhiro, Shono, Takayoshi, Tachibana, Kaoru, Hatano, Keigo, Okada, Yuta, Kimura, Sachiko, Seo, Noriko, Doki, Masatsugu, Tanaka, Yoshihiro, Hatta, Satoshi, Takahashi, Yoshinobu, Kanda
Publikováno v:
Bone marrow transplantation.
Autor:
Moyu, Kimura, Yu, Nishiyama, Hiroki, Ueda, Akiko, Kitajo, Tomoyuki, Arimatsu, Mai, Kuboki, Atsushi, Takahata, Makiko, Saito, Chizuko, Sakashita, Keigo, Okada, Yoshihiro, Umezawa, Toshikage, Nagao, Masahide, Yamamoto, Shuji, Tohda, Minoru, Tanabe, Takehiko, Mori, Ayako, Nogami
Publikováno v:
[Rinsho ketsueki] The Japanese journal of clinical hematology. 63(4)
Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by hemolysis, thrombosis, and bone marrow failure. Infection, pregnancy, and surgical operation have the potential to evoke severe episodes of hemolysis and thrombosis. Therefore, the use of
Autor:
Mai Kuboki, Yotaro Motomura, Toshikage Nagao, Ayako Nogami, Keigo Okada, Masahide Yamamoto, Yoshihiro Umezawa, Osamu Miura
Publikováno v:
In Vivo
Background Neurotoxicity is one of the dangerous complications of chimeric antigen receptor (CAR) T-cell therapy, while its pathophysiology remains to be fully understood. Motor weakness not associated with central nervous system (CNS) toxicity has r