Zobrazeno 1 - 10 of 35 pro vyhledávání: '"Keigo Morita"'
1
Akademický článek
Time and dose selective glucose metabolism for glucose homeostasis and energy conversion in the liver
Autor: Yifei Pan, Atsushi Hatano, Satoshi Ohno, Keigo Morita, Toshiya Kokaji, Yunfan Bai, Hikaru Sugimoto, Riku Egami, Akira Terakawa, Dongzi Li, Saori Uematsu, Hideki Maehara, Suguru Fujita, Hiroshi Inoue, Yuka Inaba, Atsushi J. Nagano, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda
Publikováno v: npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-22 (2024)
Abstract Hepatic glucose metabolism serves dual purposes: maintaining glucose homeostasis and converting glucose into energy sources; however, the underlying mechanisms are unclear. We quantitatively measured liver metabolites, gene expression, and p
Externí odkaz: https://doaj.org/article/3fcfca786a744fb18cb58409de0c7eef
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2
Akademický článek
DNA hypomethylation characterizes genes encoding tissue-dominant functional proteins in liver and skeletal muscle
Autor: Hideki Maehara, Toshiya Kokaji, Atsushi Hatano, Yutaka Suzuki, Masaki Matsumoto, Keiichi I. Nakayama, Riku Egami, Takaho Tsuchiya, Haruka Ozaki, Keigo Morita, Masaki Shirai, Dongzi Li, Akira Terakawa, Saori Uematsu, Ken-ichi Hironaka, Satoshi Ohno, Hiroyuki Kubota, Hiromitsu Araki, Fumihito Miura, Takashi Ito, Shinya Kuroda
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Each tissue has a dominant set of functional proteins required to mediate tissue-specific functions. Epigenetic modifications, transcription, and translational efficiency control tissue-dominant protein production. However, the coordination
Externí odkaz: https://doaj.org/article/98436c9b09ae438fad492d1943038991
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3
Akademický článek
In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states
Autor: Toshiya Kokaji, Miki Eto, Atsushi Hatano, Katsuyuki Yugi, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken-ichi Hironaka, Yuki Ito, Riku Egami, Saori Uematsu, Akira Terakawa, Yifei Pan, Hideki Maehara, Dongzi Li, Yunfan Bai, Takaho Tsuchiya, Haruka Ozaki, Hiroshi Inoue, Hiroyuki Kubota, Yutaka Suzuki, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Metabolic regulation in skeletal muscle is essential for blood glucose homeostasis. Obesity causes insulin resistance in skeletal muscle, leading to hyperglycemia and type 2 diabetes. In this study, we performed multiomic analysis of the ske
Externí odkaz: https://doaj.org/article/dd5db8b9f47843dbacf9bbaaf001a016
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4
Akademický článek
Trans-omics analysis of insulin action reveals a cell growth subnetwork which co-regulates anabolic processes
Autor: Akira Terakawa, Yanhui Hu, Toshiya Kokaji, Katsuyuki Yugi, Keigo Morita, Satoshi Ohno, Yifei Pan, Yunfan Bai, Andrey A. Parkhitko, Xiaochun Ni, John M. Asara, Martha L. Bulyk, Norbert Perrimon, Shinya Kuroda
Publikováno v: iScience, Vol 25, Iss 5, Pp 104231- (2022)
Summary: Insulin signaling promotes anabolic metabolism to regulate cell growth through multi-omic interactions. To obtain a comprehensive view of the cellular responses to insulin, we constructed a trans-omic network of insulin action in Drosophila
Externí odkaz: https://doaj.org/article/2f11eb9ab7944adc856e74542facdc46
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5
Akademický článek
Trans-omic analysis reveals obesity-associated dysregulation of inter-organ metabolic cycles between the liver and skeletal muscle
Autor: Riku Egami, Toshiya Kokaji, Atsushi Hatano, Katsuyuki Yugi, Miki Eto, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken-ichi Hironaka, Saori Uematsu, Akira Terakawa, Yunfan Bai, Yifei Pan, Takaho Tsuchiya, Haruka Ozaki, Hiroshi Inoue, Shinsuke Uda, Hiroyuki Kubota, Yutaka Suzuki, Masaki Matsumoto, Keiichi I. Nakayama, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda
Publikováno v: iScience, Vol 24, Iss 3, Pp 102217- (2021)
Summary: Systemic metabolic homeostasis is regulated by inter-organ metabolic cycles involving multiple organs. Obesity impairs inter-organ metabolic cycles, resulting in metabolic diseases. The systemic landscape of dysregulated inter-organ metaboli
Externí odkaz: https://doaj.org/article/16277b1822a647cf9a657d68049c4b26
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6
Environmental DNA analysis provides an overview of distribution patterns of two dojo loach species within the Naka-ikemi Wetland, Fukui Prefecture, Japan
Autor: Satsuki Tsuji, Ryuya Okada, Tadao Kitagawa, Keigo Morita, Hiroki Yamanaka, Naoki Shibata
Publikováno v: Ichthyological Research. 68:198-206
In the Naka-ikemi Wetland, a cryptic species of the dojo loach, Misgurnus sp. Type I (called Type I loach herein), inhabits along with the common nominal species, Misgurnus anguillicaudatus (called Type II loach herein). In this study, the distributi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79dd7b6fa6177bb53f9050127f4e4cc5
https://doi.org/10.1007/s10228-020-00776-0
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9
Trans-omic analysis reveals obesity-associated dysregulation of inter-organ metabolic cycles between the liver and skeletal muscle
Autor: Akira Terakawa, Satoshi Ohno, Katsuyuki Yugi, Haruka Ozaki, Yutaka Suzuki, Tomoyoshi Soga, Atsushi Hatano, Shinsuke Uda, Hiroyuki Kubota, Toshiya Kokaji, Akiyoshi Hirayama, Riku Egami, Takaho Tsuchiya, Masaki Matsumoto, Miki Eto, Keigo Morita, Yunfan Bai, Keiichi I. Nakayama, Masashi Fujii, Yifei Pan, Ken-ichi Hironaka, Saori Uematsu, Shinya Kuroda, Hiroshi Inoue
Publikováno v: iScience
iScience, Vol 24, Iss 3, Pp 102217-(2021)
Summary Systemic metabolic homeostasis is regulated by inter-organ metabolic cycles involving multiple organs. Obesity impairs inter-organ metabolic cycles, resulting in metabolic diseases. The systemic landscape of dysregulated inter-organ metabolic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb24a622c5f051b9b36972473d7cde0
https://pubmed.ncbi.nlm.nih.gov/33748705
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