Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Keigo Machida"'
Autor:
Hye Yeon Choi, Yicheng Zhu, Xuyao Zhao, Simran Mehta, Juan Carlos Hernandez, Jae-Jin Lee, Yi Kou, Risa Machida, Mauro Giacca, Giannino Del Sal, Ratna Ray, Hyungjin Eoh, Stanley M. Tahara, Lin Chen, Hidekazu Tsukamoto, Keigo Machida
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 2, Pp 461-477 (2024)
Abstract The P53-destabilizing TBC1D15-NOTCH protein interaction promotes self-renewal of tumor-initiating stem-like cells (TICs); however, the mechanisms governing the regulation of this pathway have not been fully elucidated. Here, we show that TBC
Externí odkaz:
https://doaj.org/article/cce91a31632d430a830e45249520ef25
Autor:
Sonal Sinha, Satoka Aizawa, Yasuhiro Nakano, Alexander Rialdi, Hye Yeon Choi, Rajan Shrestha, Stephanie Q. Pan, Yibu Chen, Meng Li, Audrey Kapelanski-Lamoureux, Gregory Yochum, Linda Sher, Satdarshan Paul Monga, Anthoula Lazaris, Keigo Machida, Michael Karin, Ernesto Guccione, Hidekazu Tsukamoto
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Hepatocellular carcinoma (HCC) is the 3rd most deadly malignancy. Activated hepatic stellate cells (aHSC) give rise to cancer-associated fibroblasts in HCC and are considered a potential therapeutic target. Here we report that selective abla
Externí odkaz:
https://doaj.org/article/6713daa54c2940a6b1e1813574aeb767
Autor:
Da-Wei Yeh, Xuyao Zhao, Hifzur R. Siddique, Mengmei Zheng, Hye Yeon Choi, Tatsuya Machida, Padmini Narayanan, Yi Kou, Vasu Punj, Stanley M. Tahara, Douglas E. Feldman, Lin Chen, Keigo Machida
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract RNA-binding protein Musashi 2 (MSI2) is elevated in several cancers and is linked to poor prognosis. Here, we tested if MSI2 promotes MYC and viral mRNA translation to induce self-renewal via an internal ribosome entry sequence (IRES). We pe
Externí odkaz:
https://doaj.org/article/f53b059996d14f06981134f03c1b966e
Autor:
Chad Nakagawa, Manjunatha Kadlera Nagaraj, Juan Carlos Hernandez, Dinesh Babu Uthay Kumar, Vivek Shukla, Risa Machida, Jörg Schüttrumpf, Linda Sher, Patrizia Farci, Lopa Mishra, Stanley M. Tahara, Jing-Hsiung James Ou, Keigo Machida
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionTumor-initiating cells (TICs) are rare, stem-like, and highly malignant. Although intravenous hepatitis B and C immunoglobulins have been used for HBV and HCV neutralization in patients, their tumor-inhibitory effects have not yet been ex
Externí odkaz:
https://doaj.org/article/c8d34736f6a64b2da84b7839e34d25e1
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-6 (2022)
Externí odkaz:
https://doaj.org/article/fe72bb846772442585b9ac6d72bed71f
Autor:
Da-Wei Yeh, Cheng Liu, Juan Carlos Hernandez, Stanley M. Tahara, Hidekazu Tsukamoto, Keigo Machida
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107035- (2023)
Summary: The synergistic effect of alcohol and HCV mediated through TLR4 signaling transactivates NANOG, a pluripotency transcription factor important for the stemness of tumor-initiating stem-like cells (TICs). NANOG together with the PRC2 complex s
Externí odkaz:
https://doaj.org/article/1675fe4bd1e34e6db075ebccf3c66458
Autor:
Chia‐Lin Chen, Juan Carlos Hernandez, Dinesh Babu Uthaya Kumar, Tatsuya Machida, Stanley M. Tahara, Anthony El‐Khoueiry, Meng Li, Vasu Punj, Suresh Kumar Swaminathan, Ameya Kirtane, Yibu Chen, Jayanth Panyam, Keigo Machida
Publikováno v:
Advanced Science, Vol 10, Iss 14, Pp n/a-n/a (2023)
Abstract A critical barrier to effective cancer therapy is the improvement of drug selectivity, toxicity, and reduced recurrence of tumors expanded from tumor‐initiating stem‐like cells (TICs). The aim is to identify circulating tumor cell (CTC)
Externí odkaz:
https://doaj.org/article/999c7bce83734a00a201565cd6d18f4d
Autor:
Juan Carlos Hernandez, Da‐Wei Yeh, Joel Marh, Hye Yeon Choi, Julia Kim, Shefali Chopra, Li Ding, Matthew Thornton, Brendan Grubbs, Leonard Makowka, Linda Sher, Keigo Machida
Publikováno v:
Hepatology Communications, Vol 6, Iss 7, Pp 1549-1560 (2022)
Abstract The ability of the liver to regenerate after injury makes it an ideal organ to study for potential therapeutic interventions. Mesenchymal stem cells (MSCs) possess self‐renewal and differentiation properties, as well as anti‐inflammatory
Externí odkaz:
https://doaj.org/article/922690c010f1446d8f5cb8b8763f520c
Autor:
Juan Carlos Hernandez, Chia-Lin Chen, Tatsuya Machida, Dinesh Babu Uthaya Kumar, Stanley M. Tahara, Jared Montana, Linda Sher, Jake Liang, Jae U. Jung, Hidekazu Tsukamoto, Keigo Machida
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106254- (2023)
Summary: Chemoresistance and plasticity of tumor-initiating stem-like cells (TICs) promote tumor recurrence and metastasis. The gut-originating endotoxin-TLR4-NANOG oncogenic axis is responsible for the genesis of TICs. This study investigated mechan
Externí odkaz:
https://doaj.org/article/226e0646bccf467da2d2c0e828ad246d
Autor:
Keigo Machida
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Neoplasms contain tumor-initiating stem-like cells (TICs) that are characterized by increased drug resistance. The incidence of many cancer types have trended downward except for few cancer types, including hepatocellular carcinoma (HCC). Therefore m
Externí odkaz:
https://doaj.org/article/8c841acc910e44109dfc33007edc6413