Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Keigo Kumagai"'
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 5 (2023)
ABSTRACT Chlamydia trachomatis infection can be regulated by autophagy-related (ATG) genes. Here, we found that the depletion of ATG9A, one of the core ATG genes, in HeLa cells suppressed C. trachomatis growth in the inclusion. The growth was restore
Externí odkaz:
https://doaj.org/article/bf51185f099540cbae27e5af57137ea6
Autor:
Osamu Sano, Aya Kobayashi, Kohjiro Nagao, Keigo Kumagai, Noriyuki Kioka, Kentaro Hanada, Kazumitsu Ueda, Michinori Matsuo
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 11, Pp 2377-2384 (2007)
ABCG1, one of the half-type ATP binding cassette (ABC) proteins, mediates the efflux of cholesterol to HDL and functions in the reverse cholesterol transport from peripheral cells to the liver. We have shown that ABCG1 mediates the efflux of not only
Externí odkaz:
https://doaj.org/article/6728118594d8422282e8422392bdad15
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 14697
The obligate intracellular bacterium Chlamydia trachomatis is the major causative agent of bacterial sexually transmitted diseases worldwide. In infected cells, the ceramide transport protein (CERT) is recruited to inclusions, where C. trachomatis re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25cd34bd4eafeb87b6114e5e3ddccf68
https://pubmed.ncbi.nlm.nih.gov/36499025
https://pubmed.ncbi.nlm.nih.gov/36499025
Autor:
Asako Goto, Daichi Egawa, Nario Tomishige, Toshiyuki Yamaji, Kentaro Shimasaki, Keigo Kumagai, Kentaro Hanada
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8576
Ceramide transport protein (CERT) mediates ceramide transfer from the endoplasmic reticulum to the Golgi for sphingomyelin (SM) biosynthesis. CERT is inactivated by multiple phosphorylation at the serine-repeat motif (SRM), and mutations that impair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c4e120575137dc2b1451c6fabc1303
https://pubmed.ncbi.nlm.nih.gov/35955719
https://pubmed.ncbi.nlm.nih.gov/35955719
Publikováno v:
International journal of molecular sciences. 23(4)
Lipid transfer proteins (LTPs) are recognized as key players in the inter-organelle trafficking of lipids and are rapidly gaining attention as a novel molecular target for medicinal products. In mammalian cells, ceramide is newly synthesized in the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171cb9ecad74455b7db029358084b285
https://pubmed.ncbi.nlm.nih.gov/35216212
https://pubmed.ncbi.nlm.nih.gov/35216212
Autor:
Keigo Kumagai, Kentaro Hanada
Publikováno v:
FEBS Letters. 593:2366-2377
The inter-organelle transport of lipids must be regulated to ensure appropriate lipid composition of each organelle. In mammalian cells, ceramide synthesised in the endoplasmic reticulum (ER) is transported to the trans-Golgi regions, where ceramide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6e833ae6c7545f64f1599c57ffc583
https://doi.org/10.1002/1873-3468.13511
https://doi.org/10.1002/1873-3468.13511
Autor:
Naoki Nakao, Masaharu Ueno, Shota Sakai, Daichi Egawa, Hiroyuki Hanzawa, Shohei Kawasaki, Keigo Kumagai, Makoto Suzuki, Shu Kobayashi, Kentaro Hanada
Publikováno v:
Communications Chemistry, Vol 2, Iss 1, Pp 1-11 (2019)
Lipid transfer proteins mediate inter-organelle transport of membrane lipids at organelle contact sites in cells, playing fundamental roles in the lipidome and membrane biogenesis in eukaryotes. We previously developed a ceramide-mimetic compound as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be23ff7c154ba1ba9613a91626e93934
http://link.springer.com/article/10.1038/s42004-019-0118-3
http://link.springer.com/article/10.1038/s42004-019-0118-3
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 4025
The ceramide transport protein (CERT) delivers ceramide from the endoplasmic reticulum (ER) to the Golgi apparatus, where ceramide is converted to sphingomyelin (SM). The function of CERT is regulated in two distinct phosphorylation-dependent events:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d00fe667bc7fa96dc37cd503a1ad1e8
https://doi.org/10.3390/ijms23074025
https://doi.org/10.3390/ijms23074025
Autor:
Koichi Watashi, Yuriko Sakamaki, Takayuki Hishiki, Shota Sakai, Kentaro Hanada, Minetaro Arita, Masayoshi Fukasawa, Takaji Wakita, Keigo Kumagai, Haruyo Aoyagi, Ayako Mimata, Toshiyuki Yamaji, Shizuko Ichinose, Ryosuke Suzuki, Hossam Gewaid, Hideki Aizaki, Masamichi Muramatsu, Fumihiro Kato
Publikováno v:
J Virol
Some plus-stranded RNA viruses generate double-membrane vesicles (DMVs), one type of the membrane replication factories, as replication sites. Little is known about the lipid components involved in the biogenesis of these vesicles. Sphingomyelin (SM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26ac7633102137fb2add6be077d148d9
https://pubmed.ncbi.nlm.nih.gov/32938759
https://pubmed.ncbi.nlm.nih.gov/32938759
Publikováno v:
Biochemical and Biophysical Research Communications. 505:1070-1076
Chlamydia trachomatis is an obligate intracellular bacterium that replicates within a membranous compartment, the inclusion, in host cells. Its intracellular life cycle requires host sphingolipids, which are in part acquired through the ER-Golgi loca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8edc95366ff681170e5590653698ca8e
https://doi.org/10.1016/j.bbrc.2018.09.168
https://doi.org/10.1016/j.bbrc.2018.09.168