Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Keigo Kanehara"'
Autor:
Takashi Hirosawa, Masaharu Ishida, Kentaro Ishii, Keigo Kanehara, Katsuyoshi Kudo, Shinobu Ohnuma, Takashi Kamei, Fuyuhiko Motoi, Takeshi Naitoh, Florin M Selaru, Michiaki Unno
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206643 (2018)
BACKGROUND:BRCA-1 associated protein (BAP1) is a de-ubiquitinating enzyme that regulates gene expression. Recently, the BAP1 mutation and its involvement in cancer survival have been reported in a range of tumor types, including uveal melanoma, mesot
Externí odkaz:
https://doaj.org/article/624abb02f39541ad9b6a5aef4da9d81e
Autor:
Michihiro Fukuda, Katsuyoshi Kudoh, Keigo Kanehara, Hiroyuki Shibata, Eduardo E. Chufan, Takeshi Naitoh, Yoshiharu Iwabuchi, Shinobu Ohnuma, Michiaki Unno, Megumi Murakami, Suresh V. Ambudkar, Masaharu Ishida, Norihiko Sugisawa
Publikováno v:
Drug Metabolism and Disposition. 45:1166-1177
Multidrug resistance (MDR) caused by the overexpression of ATP-binding cassette (ABC) transporters in cancer cells is a major obstacle in cancer chemotherapy. Previous studies have shown that curcumin, a natural product and a dietary constituent of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d261b656f6345f830ec0831c7d8ca14
https://doi.org/10.1124/dmd.117.076000
https://doi.org/10.1124/dmd.117.076000
Autor:
Kazuhiro Watanabe, S. Sato, Shinobu Ohnuma, Katsuyoshi Kudoh, Hideaki Karasawa, Michiaki Unno, Takeshi Naitoh, Keigo Kanehara, Masaharu Ishida, Fuyuhiko Motoi
Publikováno v:
The Japanese Journal of Gastroenterological Surgery. 50:754-761
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa294e183abb743aeb903add5597fcc0
https://doi.org/10.5833/jjgs.2016.0158
https://doi.org/10.5833/jjgs.2016.0158
Autor:
Takehiro Suzuki, Takaaki Abe, Keigo Kanehara, Shoji Kokubo, Hideaki Karasawa, Keisuke Sato, Chitose Suzuki, Shinobu Ohnuma, Michiaki Unno, Yoshitake Kanazawa, Takeshi Naitoh, Hideyuki Suzuki
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
In inflammatory bowel disease, chronic inflammation results in the development of colon cancer known as colitis-associated cancer. This disease is associated with tumor necrosis factor-α (TNF-α) signaling. In addition, intestinal fibrosis is a comm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f91267d75afed398760d4ed2947edc
https://doi.org/10.1038/s41598-019-48974-9
https://doi.org/10.1038/s41598-019-48974-9
Autor:
Keigo, Kanehara, Shinobu, Ohnuma, Hideyuki, Suzuki, Akihiro, Yamamura, Hideaki, Karasawa, Atsushi, Kohyama, Takeshi, Aoki, Kazuhiro, Watanabe, Naoki, Tanaka, Hiroaki, Musha, Fuyuhiko, Motoi, Takashi, Kamei, Takeshi, Naitoh, Michiaki, Unno
Publikováno v:
Gan to kagaku ryoho. Cancerchemotherapy. 45(13)
Case 1: A female patient in her 60s underwent laparoscopic intersphincteric resection for rectal cancer. After 42 months, the serum level of carcinoembryonic antigen(CEA)was elevated, and PET-CT showed a locally recurrent rectal cancer that increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb9cc5b44d0c7dd17e1928b0bc3fab02
https://pubmed.ncbi.nlm.nih.gov/30692404
https://pubmed.ncbi.nlm.nih.gov/30692404
Publikováno v:
Cancer Research. 80:6123-6123
Backgrounds: In inflammatory bowel disease (IBD), chronic inflammation results in the development of colon cancer known as colitis-associated cancer (CAC), that is associated with tumor necrosis factor-α (TNF-α) signaling. In addition, intestinal f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5ab1118e7ad71187a5a6cde9e05e72d
https://doi.org/10.1158/1538-7445.am2020-6123
https://doi.org/10.1158/1538-7445.am2020-6123
Autor:
Shoji Kokubo, Shinobu Ohnuma, Hideaki Karasawa, Akihiro Yamamura, Hideyuki Suzuki, Megumi Murakami, Norihiko Sugisawa, Keigo Kanehara, Keisuke Sato, Takanori Ishida, Takashi Kamei, Takeshi Naitoh, Michiaki Unno
Publikováno v:
Cancer Research. 79:25-25
Background: ABCG2, also known as breast cancer resistance protein (BCRP), is a member of the ATP-binding cassette (ABC)-family of membrane transport proteins associated with multidrug resistance (MDR). No ABCG2 inhibitor has shown clinical significan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce7631f565e1fefbc5a01428d4c5449e
https://doi.org/10.1158/1538-7445.am2019-25
https://doi.org/10.1158/1538-7445.am2019-25
Autor:
Shinobu Ohnuma, Wang Dang Yang, Hideyuki Suzuki, Keigo Kanehara, Hideaki Karasawa, Atsushi Kohyama, Kazuhiro Watanabe, Koh Miura, Takashi Kamei, Takeshi Naitoh, Michiaki Unno
Publikováno v:
Cancer Research. 79:352-352
Aim: To reveal whether anti TNF-α antibody (Ab) induces colon carcinogenesis or not in colitic cancer models. Methods: The effects of TNF-α and anti TNF-α Ab were analyzed with cell-proliferation, migration, and invasion assays in human colon canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3a1cdab6806b08a5517123c978f91a9
https://doi.org/10.1158/1538-7445.am2019-352
https://doi.org/10.1158/1538-7445.am2019-352