Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Keigo Araki"'
Autor:
Keigo Araki, Takeru Torii, Kohei Takeuchi, Natsuki Kinoshita, Ryoto Urano, Rinka Nakajima, Yaxuan Zhou, Tokuo Kobayashi, Tadayoshi Hanyu, Kiyoshi Ohtani, Kimiharu Ambe, Keiko Kawauchi
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 57, Iss , Pp 101044- (2024)
Multinucleation occurs in various types of advanced cancers and contributes to their malignant characteristics, including anticancer drug resistance. Therefore, inhibiting multinucleation can improve cancer prognosis; however, the molecular mechanism
Externí odkaz:
https://doaj.org/article/f51ae573f0e7445cae640d305efa2a44
Autor:
Lin Zhao, Rinka Nakajima, Yaxuan Zhou, Mashiro Shirasawa, Mariana Fikriyanti, Yuki Kamiya, Hiroyuki Toh, Hideyuki Komori, Ritsuko Iwanaga, Andrew P. Bradford, Hideo Nishitani, Kenta Kurayoshi, Keigo Araki, Kiyoshi Ohtani
Publikováno v:
Biomolecules, Vol 14, Iss 11, p 1357 (2024)
The transcription factor E2F1 is the principal target of the tumor suppressor pRB. E2F1 promotes cell proliferation by activating growth-promoting genes upon growth stimulation. In contrast, E2F1 contributes to tumor suppression by activating tumor s
Externí odkaz:
https://doaj.org/article/a342bd13182649b890625fdf3eb07618
Autor:
Yaxuan Zhou, Rinka Nakajima, Mashiro Shirasawa, Mariana Fikriyanti, Lin Zhao, Ritsuko Iwanaga, Andrew P. Bradford, Kenta Kurayoshi, Keigo Araki, Kiyoshi Ohtani
Publikováno v:
Biology, Vol 12, Iss 12, p 1511 (2023)
The transcription factor E2F links the RB pathway to the p53 pathway upon loss of function of pRB, thereby playing a pivotal role in the suppression of tumorigenesis. E2F fulfills a major role in cell proliferation by controlling a variety of growth-
Externí odkaz:
https://doaj.org/article/6ccef8f5458c4c6bb40ff2e7fd72d812
Autor:
Zhihai Zhao, Song Hui Tan, Hiroaki Machiyama, Keiko Kawauchi, Keigo Araki, Hiroaki Hirata, Yasuhiro Sawada
Publikováno v:
Biology Open, Vol 5, Iss 4, Pp 499-506 (2016)
Cell migration is a highly dynamic process that plays pivotal roles in both physiological and pathological processes. We have previously reported that p130Cas supports cell migration through the binding to Src as well as phosphorylation-dependent ass
Externí odkaz:
https://doaj.org/article/cf2d616e55bf44d8b455e6c50d5f46b8
Publikováno v:
eLife, Vol 2 (2013)
Skeletal muscle degeneration is a complication arising from a variety of chronic diseases including advanced cancer. Pro-inflammatory cytokine TNF-α plays a pivotal role in mediating cancer-related skeletal muscle degeneration. Here, we show a novel
Externí odkaz:
https://doaj.org/article/2dfbdde653f74692b0d1b82e291df693
Autor:
Rinka Nakajima, Reika Deguchi, Hideyuki Komori, Lin Zhao, Yaxuan Zhou, Mashiro Shirasawa, Arlene Angelina, Yasuko Goto, Fumiya Tohjo, Kengo Nakahashi, Kimi Nakata, Ritsuko Iwanaga, Andrew P. Bradford, Keigo Araki, Tomoko Warita, Kiyoshi Ohtani
Publikováno v:
Biochemical and Biophysical Research Communications. 663:154-162
Autor:
Rinka Nakajima, Lin Zhao, Yaxuan Zhou, Mashiro Shirasawa, Ayato Uchida, Hikaru Murakawa, Mariana Fikriyanti, Ritsuko Iwanaga, Andrew P. Bradford, Keigo Araki, Tomoko Warita, Kiyoshi Ohtani
Publikováno v:
Genes. 14:393
The transcription factor E2F, the principal target of the tumor suppressor pRB, plays crucial roles in cell proliferation and tumor suppression. In almost all cancers, pRB function is disabled, and E2F activity is enhanced. To specifically target can
Autor:
Andrew P. Bradford, Kiyoshi Ohtani, Kenta Kurayoshi, Eiko Ozono, Hideyuki Komori, Keigo Araki, Ritsuko Iwanaga, Yasuko Goto
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports
The transcription factor E2F plays crucial roles in cell proliferation and tumor suppression by activating growth-related genes and pro-apoptotic tumor suppressor genes, respectively. It is generally accepted that E2F binds to target sequences with i
Autor:
Andrew P. Bradford, Eiko Ozono, Ritsuko Iwanaga, Ayumi Shiromoto, Kenta Kurayoshi, Kiyoshi Ohtani, Keigo Araki
Publikováno v:
Biochemical and Biophysical Research Communications. 483:107-114
In cancer treatment, specifically targeting cancer cells is important for optimal therapeutic efficacy. One strategy is to utilize a cancer specific promoter to express a cytotoxic gene or a viral gene required for replication. In this approach, the