Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Keibler, Mark Andrew"'
Autor:
Keibler, Mark Andrew
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2017.
Cataloged from PDF version of thesis.
Includes bibliographical references.
Cancer remains a leading worldwide health problem, and in the U
Cataloged from PDF version of thesis.
Includes bibliographical references.
Cancer remains a leading worldwide health problem, and in the U
Externí odkaz:
http://hdl.handle.net/1721.1/115016
Autor:
Kerry A. Pierce, Gregory Stephanopolous, Dan Y. Gui, Lakshmipriya Subbaraj, Mark A. Keibler, Tyler Jacks, Thales Papagiannakopoulos, Bryan T. Mott, Lucas B. Sullivan, Clary B. Clish, Thomas M. Wasylenko, Matthew G. Vander Heiden, Matthew R. Bauer, Alba Luengo, James P. O’Brien, Abhishek K. Jha, Shawn M. Davidson, Benjamin A. Olenchock, Christopher R. Chin, Julia E. Heyman
Publikováno v:
PMC
Cultured cells convert glucose to lactate, and glutamine is the major source of tricarboxylic acid (TCA)-cycle carbon, but whether the same metabolic phenotype is found in tumors is less studied. We infused mice with lung cancers with isotope-labeled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de6a0e1b2ca0fee202deb10989c8a59
Autor:
Joshua D. Rabinowitz, Alex Lammers, Alba Luengo, Kendall J. Condon, Jongyoon Han, Dafna Bar-Sagi, Jeffrey Wyckoff, Michael J. Cima, Robert Langer, Katherine A Kellersberger, Christopher R. Chin, Brian K Stall, Shawn M. Davidson, Jared R. Mayers, Mark A. Keibler, Han Wei Hou, Oliver Jonas, Matthew Whitman, Gregory Stephanopoulos, Amanda M. Del Rosario, Matthew G. Vander Heiden
Publikováno v:
PMC
Mammalian tissues rely on a variety of nutrients to support their physiological functions. It is known that altered metabolism is involved in the pathogenesis of cancer, but which nutrients support the inappropriate growth of intact malignant tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c8320f7d8df5b9c5e8e5e4d5620cf0d
https://pubmed.ncbi.nlm.nih.gov/28096538
https://pubmed.ncbi.nlm.nih.gov/28096538
Autor:
Joanne K. Kelleher, Thomas M. Wasylenko, Mark A. Keibler, Gregory Stephanopoulos, Matthew G. Vander Heiden, Othon Iliopoulos
Publikováno v:
BioMedCentral
Cancer & Metabolism
Cancer & Metabolism
Background: The study of cancer metabolism has been largely dedicated to exploring the hypothesis that oncogenic transformation rewires cellular metabolism to sustain elevated rates of growth and division. Intense examination of tumors and cancer cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd0aa3304ffcc73b7bf53b64f4431c91
http://hdl.handle.net/1721.1/116916
http://hdl.handle.net/1721.1/116916
Autor:
Vadim Molla, Donglim Esther Park, James A. DeCaprio, Christian Berrios, John Quackenbush, Megha Padi, Mark A. Keibler, Jingwei Cheng, Gregory Stephanopoulos, Soo Mi Lee
Publikováno v:
PLoS Pathogens
PLoS
PLoS Pathogens, Vol 12, Iss 11, p e1006020 (2016)
PLoS
PLoS Pathogens, Vol 12, Iss 11, p e1006020 (2016)
Merkel cell polyomavirus (MCPyV) is an etiological agent of Merkel cell carcinoma (MCC), a highly aggressive skin cancer. The MCPyV small tumor antigen (ST) is required for maintenance of MCC and can transform normal cells. To gain insight into cellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877e76fd19a1ddddc8c8f47c85a10c0d
https://pubmed.ncbi.nlm.nih.gov/27880818
https://pubmed.ncbi.nlm.nih.gov/27880818
Autor:
Lewis C. Cantley, Grégory Johann Wirth, Akash Patnaik, Shawn M. Davidson, Eric L. Bell, Marie Jose Blouin, Brian P. Fiske, Jared R. Mayers, Gregory Stephanopoulos, Gary Bellinger, John Blenis, Mark A. Keibler, Sarah-Maria Fendt, Leonard Guarente, Alfredo Csibi, Matthias Schwab, Michael Pollak, Matthew G. Vander Heiden, Aria F. Olumi
Publikováno v:
PMC
Metformin inhibits cancer cell proliferation, and epidemiology studies suggest an association with increased survival in patients with cancer taking metformin; however, the mechanism by which metformin improves cancer outcomes remains controversial.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e51e6bd433ea72366dba36e2d0d1a73
https://orcid.org/0000-0003-0701-5275
https://orcid.org/0000-0003-0701-5275
Publikováno v:
PMC
The metabolic engineer's toolbox, comprising stable isotope tracers, flux estimation and analysis, pathway identification, and pathway kinetics and regulation, among other techniques, has long been used to elucidate and quantify pathways primarily in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85dfc27ab6bc61b581e84effc4eb8771
https://orcid.org/0000-0002-5410-6543
https://orcid.org/0000-0002-5410-6543