Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Kei-ichi Sugiyama"'
Autor:
Sayaka Hosoi, Takako Hirose, Shoji Matsumura, Yuki Otsubo, Kazutoshi Saito, Masaaki Miyazawa, Takayoshi Suzuki, Kenichi Masumura, Kei-ichi Sugiyama
Publikováno v:
Genes and Environment, Vol 46, Iss 1, Pp 1-8 (2024)
Abstract Background Error-corrected next-generation sequencing (ecNGS) technologies have enabled the direct evaluation of genome-wide mutations after exposure to mutagens. Previously, we reported an ecNGS methodology, Hawk-Seq™, and demonstrated it
Externí odkaz:
https://doaj.org/article/e876de90d61a4d3e9c5ea31ae8bfd52e
Autor:
Takako Iso, Kenichiro Suzuki, Yasumasa Murata, Nozomu Hirose, Takaaki Umano, Katsuyoshi Horibata, Kei-ichi Sugiyama, Akihiko Hirose, Kenichi Masumura, Mariko Matsumoto
Publikováno v:
Genes and Environment, Vol 46, Iss 1, Pp 1-8 (2024)
Abstract Background Carbendazim (methyl 2-benzimidazolecarbamate, CASRN: 10605-21-7) exhibits spindle poisoning effects and is widely used as a fungicide. With respect to genotoxicity, carbendazim is deemed to be non-mutagenic in vitro, but it causes
Externí odkaz:
https://doaj.org/article/d173ef94bfb2421bb06ba6963778978e
Autor:
Masayuki Mishima, Kei-ichi Sugiyama
Publikováno v:
Genes and Environment, Vol 45, Iss 1, Pp 1-6 (2023)
Abstract Background Middle size peptides (MSPs) have emerged as a promising new pharmaceutical modality. We are seeking the best way to assess the non-clinical safety of MSPs. Consideration The requirements for assessing the genotoxicity of pharmaceu
Externí odkaz:
https://doaj.org/article/5267f5158d404dc986097306cf4150a9
Autor:
Yasumasa Murata, Kenichiro Suzuki, Yoshiyuki Shigeta, Takako Iso, Nozomu Hirose, Takaaki Umano, Katsuyoshi Horibata, Kei-ichi Sugiyama, Akihiko Hirose, Kenichi Masumura, Mariko Matsumoto
Publikováno v:
Genes and Environment, Vol 45, Iss 1, Pp 1-9 (2023)
Abstract Background tert-Butyl hydroperoxide (TBHP; CAS 75–91-2), a hydroperoxide, is mainly used as a polymerization initiator to produce polyethylene, polyvinyl chloride, and unsaturated polyester. It is a high-production chemical, widely used in
Externí odkaz:
https://doaj.org/article/6c9e774740ab49d695e5037243d9bd1c
Publikováno v:
Genes and Environment, Vol 45, Iss 1, Pp 1-8 (2023)
Abstract Background Mutagenicity, the ability of chemical agents to cause mutations and potentially lead to cancer, is a critical aspect of substance safety assessment for protecting human health and the environment. Metabolic enzymes activate multip
Externí odkaz:
https://doaj.org/article/b5e3715d87a846bc99e3c5ba6095b4c1
Autor:
Yasumasa Murata, Masakatsu Natsume, Takako Iso, Yoshiyuki Shigeta, Nozomu Hirose, Takaaki Umano, Katsuyoshi Horibata, Kei-ichi Sugiyama, Kenichi Masumura, Akihiko Hirose, Mariko Matsumoto
Publikováno v:
Genes and Environment, Vol 45, Iss 1, Pp 1-11 (2023)
Abstract Background Styrene (CAS 100-42-5) is widely used as polystyrene and acrylonitrile–butadiene–styrene resin such as plastic, rubber, and paint. One of the primary uses of styrene is food utensils and containers, but a small amount of styre
Externí odkaz:
https://doaj.org/article/2ba5467ff8fc457fa0a44d7e1fe3d059
Autor:
Katsuyoshi Horibata, Hironao Takasawa, Motoki Hojo, Yuhji Taquahashi, Miyuki Shigano, Satoshi Yokota, Norihiro Kobayashi, Kei-ichi Sugiyama, Masamitsu Honma, Shuichi Hamada
Publikováno v:
Genes and Environment, Vol 44, Iss 1, Pp 1-7 (2022)
Abstract Background Multiwalled carbon nanotubes (MWCNTs) are suspected lung carcinogens because their shape and size are similar to asbestos. Various MWCNT types are manufactured; however, only MWNT-7 is classified into Group 2B by The International
Externí odkaz:
https://doaj.org/article/fc3775cf014146ff9ba06feb5dab0149
Publikováno v:
Genes and Environment, Vol 44, Iss 1, Pp 1-8 (2022)
Abstract Bisphenol-A (BPA) is an important environmental contaminant with adverse health effects suspected to be mediated through epigenetic mechanisms. We had reported that the FLO1-dependent flocculation of transgenic yeast expressing human DNA met
Externí odkaz:
https://doaj.org/article/521c13294ad5492dac496d7ca3478b66
Autor:
Masamitsu Honma, Masami Yamada, Manabu Yasui, Katsuyoshi Horibata, Kei-ichi Sugiyama, Kenichi Masumura
Publikováno v:
Toxicology Reports, Vol 9, Iss , Pp 1008-1012 (2022)
We assessed the genotoxicity of 30 food-flavoring chemicals used in Japan that have not been investigated before. These 30 food-flavoring chemicals have representative chemical structures belonging to 18 chemical classes. The Ames and chromosomal abe
Externí odkaz:
https://doaj.org/article/a98a2a9440d34653b535ac6b9080afb8
Autor:
Masamitsu Honma, Masami Yamada, Manabu Yasui, Katsuyoshi Horibata, Kei-ichi Sugiyama, Kenichi Masumura
Publikováno v:
Genes and Environment, Vol 43, Iss 1, Pp 1-11 (2021)
Abstract Background Perillaldehyde and cinnamaldehyde are natural substances found in plants that are used as flavoring ingredients. Due to the α,β-unsaturated aldehydes in their structures, these compounds are expected to be DNA reactive. Indeed,
Externí odkaz:
https://doaj.org/article/606c347fbcb44d078b3a17dea5f712a6