Výsledky vyhledávání - "Kei-ichi NAKAYAMA"

Interaction between Cyclin T1 and SCFSKP2 Targets CDK9 for Ubiquitination and Degradation by the Proteasome

Autor: Monsef Benkirane, Keiko Nakayama, Kei-ichi Nakayama, Rosemary Kiernan, Jean-Claude Labbé, Anna Castro, Thierry Lorca, Stéphane Emiliani

Publikováno v: Molecular and Cellular Biology. 21:7956-7970

Transcriptional elongation is regulated by both positive and negative transcription elongation factors and is recognized as an important target for transcriptional regulation (37). The human positive transcription elongation factor b (P-TEFb) is comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4c352b498b351736859e0dee7b4772
https://doi.org/10.1128/mcb.21.23.7956-7970.2001

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CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70

Autor: Makoto, Urushitani, Junko, Kurisu, Minako, Tateno, Shigetsugu, Hatakeyama, Kei-Ichi, Nakayama, Shinsuke, Kato, Ryosuke, Takahashi

Publikováno v: Journal of neurochemistry. 90(1)

Over 100 mutants in superoxide dismutase 1 (SOD1) are reported in familial amyotrophic lateral sclerosis (ALS). However, the precise mechanism by which they are degraded through a ubiquitin-proteasomal pathway (UPP) remains unclear. Here, we report t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3e958c15e0c31a2b4285c6242b84357
https://pubmed.ncbi.nlm.nih.gov/15198682

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[Mechanisms to control degradation of polyglutamine-containing protein]

Autor: Kei-Ichi, Nakayama

Publikováno v: Rinsho shinkeigaku = Clinical neurology. 43(11)

Machado-Joseph disease (MJD)/Spinocerebellar ataxia type 3 (SCA3) is neurodegenerative disease which is caused by polyglutamine expansion in a responsible gene product, MJD1/Ataxin3. MJD1 has now been shown to undergo ubiquitylation and degradation b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::93e66623dbf1178475b1c8eb3c95b654
https://pubmed.ncbi.nlm.nih.gov/15152500

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Intracellular signal transduction of interferon on the suppression of haematopoietic progenitor cell growth

Autor: Kouji, Kato, Kenjirou, Kamezaki, Kazuya, Shimoda, Akihiko, Numata, Takashi, Haro, Kenichi, Aoki, Fumihiko, Ishikawa, Ken, Takase, Hiroshi, Ariyama, Tadashi, Matsuda, Toshihiro, Miyamoto, Koji, Nagafuji, Hisashi, Gondo, Kei-Ichi, Nakayama, Mine, Harada

Publikováno v: British journal of haematology. 123(3)

Interferon (IFN)-alpha and IFN-gamma suppress the growth of haematopoietic progenitor cells. IFN-alpha activates Janus kinase-1 (Jak1) and Tyrosine kinase-2 (Tyk2), followed by the phosphorylation of the signal transducers and activators of transcrip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::23d7b265b40f5ef730839c482452b433
https://pubmed.ncbi.nlm.nih.gov/14617019

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A novel route for connexin 43 to inhibit cell proliferation: negative regulation of S-phase kinase-associated protein (Skp 2)

Autor: You-Wei, Zhang, Keiko, Nakayama, Kei-Ichi, Nakayama, Ikuo, Morita

Publikováno v: Cancer research. 63(7)

Accumulated evidence suggests that connexin43 (Cx43) serves as a tumor-suppressing gene. We have previously shownA. B. that Cx43 suppressed the G(1)-S phase cell cycle transition via increasing the level of p27 (Zhang, Y. W., et al., Oncogene, 20: 41

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::874cc13857bfcab1124dbf826a5584cc
https://pubmed.ncbi.nlm.nih.gov/12670914

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The second phase activation of protein kinase C delta at late G1 is required for DNA synthesis in serum-induced cell cycle progression

Autor: Koichi, Kitamura, Keiko, Mizuno, Akiko, Etoh, Yoshiko, Akita, Akitomo, Miyamoto, Kei-Ichi, Nakayama, Shigeo, Ohno

Publikováno v: Genes to cells : devoted to molecularcellular mechanisms. 8(4)

Cell lines that stably over-express protein kinase C (PKC) delta frequently show a decrease in growth rate and saturation density, leading to the hypothesis that PKC delta has a negative effect on cell proliferation. However, the mode of PKC delta ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3454158ae12ca98e9e25d4441fc28052
https://pubmed.ncbi.nlm.nih.gov/12653960

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Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysis

Autor: Taka-aki, Masuda, Hiroshi, Inoue, Hideto, Sonoda, Shinji, Mine, Yasuji, Yoshikawa, Keiko, Nakayama, Kei-Ichi, Nakayama, Masaki, Mori

Publikováno v: Cancer research. 62(13)

Reduced expression level of p27, a cyclin-dependent kinase inhibitor, is associated with high aggressiveness and poor prognosis of various malignant tumors, including gastric carcinoma. S-phase kinase-associated protein 2 (Skp2), a member of the F-bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::017fc9f66cb9a72f40e379e2f924d987
https://pubmed.ncbi.nlm.nih.gov/12097295

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Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice

Autor: Yohji A, Minamishima, Keiko, Nakayama, Kei-Ichi, Nakayama

Publikováno v: Cancer research. 62(4)

The abundance of p27(Kip1), an inhibitor of cell proliferation, is determined by Skp2-dependent proteolysis, the deregulation of which is associated with cancer progression. Lack of Skp2 results in p27(Kip1) accumulation as well as enlargement and po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8d5d8b0649e6decf4fa196be0ac26327
https://pubmed.ncbi.nlm.nih.gov/11861371

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