Výsledky vyhledávání - "Kei-ichi Kawagoe"

Discovery of diaminobutane derivatives as Ca(2+)-permeable AMPA receptor antagonists

Autor: Masaki Saito, Yoshiyuki Yoneda, Shinichi Kawajiri, Kei-ichi Kawagoe, Toshiaki Tatematu, Masayuki Ito, Takanori Yasukouchi, Tetuya Mimura, Masunobu Sugimura, Fusako Kito

Publikováno v: Bioorganicmedicinal chemistry. 10(5)

We designed and synthesized a series of the polyamine derivatives as potent Ca2+-permeable AMPA receptor antagonists. In the course of this study, we found that the polyamine derivatives exhibited strong hypotensive activity which was undesirable act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695b3576d7e3df3d7cc9b724d2c7279f
https://pubmed.ncbi.nlm.nih.gov/11886798

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Synthesis of phenoxyacetic acid derivatives as highly potent antagonists of gastrin/cholecystokinin-B receptors. II

Autor: Kei-ichi Kawagoe, Toru Hosokami, Yasuyuki Takeda, Yoshiyasu Ogihara, Yoshiaki Tabuchi, Yokomizo Aki, Rira Otsubo, Shuichi Yokohama, Yuko Honda, Yoshihiro Yokomizo, Yoshimasa Shimoto

Publikováno v: Chemicalpharmaceutical bulletin. 46(6)

A novel series of phenoxyacetic acid derivatives was synthesized based on considerations of the three-dimensional structural similarity of YM022 and RP72540. The gastrin/cholecystokinin (CCK)-B and CCK-A receptor antagonist activities of these compou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ccf6c810200c83b984bd7e9a0fafc2
https://pubmed.ncbi.nlm.nih.gov/9658573

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Synthesis and antitumor activity of novel benzophenone derivatives

Autor: Eiji Kumazawa, Tamotsu Miwa, S. Clifford Burford, Kei-ichi Kawagoe, Kenji Hirotani, Akio Ejima, Ikuo Mitsui

Publikováno v: Chemicalpharmaceutical bulletin. 45(9)

Novel benzophenone derivatives were synthesized and screened for cytotoxic and antitumor activity. Friedel-Crafts condensation was employed to construct the benzophenone skeleton. Among the compounds synthesized, morpholino and thiomorpholino benzoph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f63544896817b5457bca06582870463
https://pubmed.ncbi.nlm.nih.gov/9331999

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Kinetic resolution of fluoroalkyl (E)-vinyl carbinol derivatives by asymmetric epoxidation with titanium-tartrate catalysts

Autor: Kei-ichi Kawagoe, Masayuki Ito, Yoshiro Kobayashi, Yuji Hanzawa

Publikováno v: Chemical and Pharmaceutical Bulletin. 35:1633-1636

Racemic fluoroalkyl (E) -vinyl carbinols (1a-d) were kinetically resolved by Sharpless epoxidation. The optical purity of the resolved alcohols was excellent (98% ee) in mono-and difluoromethyl derivatives (1b and 1c) and moderate (60% ee) in a trifl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fdf7b80c4a85eaff6c466f7540b23323
https://doi.org/10.1248/cpb.35.1633

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Syntheses of trifluoromethylated diene derivatives through the claisen rearrangement of trifluoromethylated propargylic and allylic alcohols

Autor: Akio Yamada, Kei-ichi Kawagoe, Yuji Hanzawa, Yoshiro Kobayashi

Publikováno v: Tetrahedron Letters. 26:219-222

3-Trifluoromethyl-2Z, 4E-dienoate ( 14 ) and the dienamide ( 10 , 11 ) were prepared through the Claisen rearrangement of trifluoromethylated propargylic and allylic alcohols.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f9f0bd1cadfe8ed96bd48a613f5d54e
https://doi.org/10.1016/s0040-4039(00)61884-1

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Hydrometallation of 1-alkyl-3-trifluoromethyl propargyl alcohols

Autor: Naomi Tanahashi, Kei-ichi Kawagoe, Yoshiro Kobayashi, Yuji Hanzawa

Publikováno v: Tetrahedron Letters. 25:4749-4752

The hydrometallation of trifluoromethylated propargyl alcohol derivatives with metal hydride reagents proceeds smoothly to give cis- and trans-olefins on H2O quenching. The halodemetallation of intermediate formed in the reaction process was also exa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ae49bfcbf07806a450ec56d596c4353
https://doi.org/10.1016/s0040-4039(01)81509-4

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