Peginesatide Clearance, Distribution, Metabolism, and Excretion in Monkeys following Intravenous Administration

Autor: Susan D. Wilson, Kei-lai Fong, Yuu Moriya, Kathryn W. Woodburn, Paul Strzemienski, Eric Solon, Yoshihiko Tagawa, Steven Sloneker

Publikováno v: Drug Metabolism and Disposition. 41:774-784

Peginesatide, a polyethylene glycol (PEG)ylated peptide-based erythropoiesis-stimulating agent, stimulates the erythropoietin receptor dimer that governs erythropoiesis. Studies were designed to determine the erythropoietic response, pharmacokinetics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198ee90bcf74277ae962def8518577f5
https://doi.org/10.1124/dmd.112.048033

Disposition, metabolism and mass balance of [14C]apremilast following oral administration

Autor: Dorota Cedzik, Zhe-ming Gu, Oscar L. Laskin, Anfan Wu, Lori Capone, Sekhar Surapaneni, Peter H. Schafer, Gondi Kumar, Kei-Lai Fong, Dennis Heller, Matthew Hoffmann, Hao Feng

Publikováno v: Xenobiotica; the Fate of Foreign Compounds in Biological Systems

Apremilast is a novel, orally available small molecule that specifically inhibits PDE4 and thus modulates multiple pro- and anti-inflammatory mediators, and is currently under clinical development for the treatment of psoriasis and psoriatic arthriti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a12f1882b88e0997a57b9ad4adcbb73
https://doi.org/10.3109/00498254.2011.604745

Preclinical Safety and Pharmacology of Hematide™, a Peptidic Erythropoiesis Stimulating Agent (ESA), in Rats and Monkeys

Autor: Thomas Ferrell, Peter J. Schatz, Kathryn W. Woodburn, Daniel Norton, Susan D. Wilson, Charles B. Spainhour, Kei-lai Fong

Publikováno v: Drug and Chemical Toxicology. 31:229-244

The pharmacology, toxicokinetics, and safety of Hematide, a synthetic peptidic erythropoiesis-stimulating agent (ESA), were characterized. Hematide was given intravenously (0, 0.5, 5, and 50 mg/kg) weekly for five weeks with a 6- (rat) and 12-week (m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a46063482ddb8da278c523ad8cc872f
https://doi.org/10.1080/01480540701873186

Peri- and postnatal rodent development of Hematide, an erythropoiesis-stimulating agent

Autor: Kei-lai Fong, Alan M. Hoberman, Peter J. Schatz, Kathryn W. Woodburn, Elise M. Lewis, Susan D. Wilson

Publikováno v: Birth Defects Research Part B: Developmental and Reproductive Toxicology.

BACKGROUND: Aperi- and postnatal reproduction toxicity study was conducted in rats treated with Hematide, a synthetic PEGylated peptidic erythropoiesis stimulating agent (ESA). METHODS: Hematide, at IV doses of 0, 0.5, 3, and 15 mg/kg, was administer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93059147539c7e26c5aadfe0cf3f5753
https://doi.org/10.1002/bdrb.20243

Anaemia in CKD 1-5

Autor: Noriyuki Okada, Karsten Roth, Naohisa Tomosugi, Adrian Zugravu, Nicanor Vega, Marina Shestakova, Alain Guerin, Josep M. Campistol, Gabriel Mircescu, M. Laville, P. Lang, Cristina Capusa, Serhat Karadag, Aritoshi Kida, Marc Froissart, Mourad Farouk, M. Fellous, Hyun Woo Kim, Yasemin Doventas, Yasushi Shimonaka, Hiroaki Kawabata, Akira Suzuki, Petronila Rocha-Pereira, Antonio Pérez, Stephan Heidenreich, Christopher Holmes, Savas Ozturk, François Vrtovsnik, Emel Tatli, Ana Stanciu, Agustín Carreño, Kosaku Nitta, Liliane Garneata, Masami Bessho, Kei-Lai Fong, Salvatore Di Giulio, Francesco Locatelli, Ricardo Correa-Rotter, Zeki Aydin, Eun Hee Jang, Rumeyza Kazancioglu, Marite Ode, Michal Mysliwiec, V. Esnault, Jacek S. Malyszko, J.-P. Ryckelynck, Lucile Mercadal, Gabriel Mirescu, Manuel Arias, Ligia Petrescu, José M. Morales, Minoru Furuta, G. Choukroun, Takuya Uehata, Alice Santos-Silva, Antonio Franco, Roland Schäfer, Luís Belo, Jan Galle, Kathleen Claes, M.J. Camba, M. Bicho, Takahiro Kuragano, Yoshinaga Otaki, Yolanta Malyszko, Nicole Casadevall, Futoshi Nisihara, Jean-Philippe Haymann, Steven Sloneker, B. Knebelman, Martin Flamant, Rie Kitamura, Masashi Suzuki, István Kiss, Ian Bridges, Piotr Kozminski, S. Bea, Minoru Ando, José Luis Górriz Teruel, Abdullah Sumnu, Walter H. Hörl, Jean-Jacques Boffa, Sami Uzun, Macit Koldas, David Goldsmith, Kakuya Niihata, Paul Strzemienski, D. Sanchez-Guisande, A. Martínez Castelao, Tatsuya Shoji, José Portolés, Pierre-Yves Martin, E. Legrand, Ewa Koc-Zorawska, Claudio Mori, Masaki Hara, V. Miranda, Gilbert Deray, Takeshi Nakanishi, Frank Leistikow, Meltem Gursu, M. Sameiro-Faria, E. Espinel, Hiroshi Nonoguchi, Chris Winearls, L. Pallardó, Ken Tsuchiya, P. Bataille, J. Calls, Mika Sonoda, C. Afonso, Kathryn Woodburn, Yusuke Sakaguchi, Aleix Cases, Yoshiharu Tsubakihara, Simona Stancu, Janet Addison, Mana Yahiro, C. Marinho, Nomy Levin-Iaina, Daniell Mitchell, Marie Metzger, Elísio Costa, Eric Solon, G. Fernández-Fresnedo, Liliana Viasu, Bénédicte Stengel

Publikováno v: Clinical Kidney Journal. 4:4.s2.32-4.s2.32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5187c5bf98e0298fc8f03c8a44dcaa07
https://doi.org/10.1093/ndtplus/4.s2.32