Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Kei-Lai Fong"'
Autor:
Kathryn W. Woodburn, Susan D. Wilson, Kei-lai Fong, Peter J. Schatz, Thomas Ferrell, Charles B. Spainhour, Daniel Norton
Publikováno v:
Haematologica, Vol 93, Iss 9 (2008)
Hematide is a synthetic peptide-based, pegylated erythropoiesis stimulating agent in clinical development for treatment of anemia. To support chronic clinical dosing requirements, a 9-month repeat dose IV monkey safety study was undertaken. Animals r
Externí odkaz:
https://doaj.org/article/27d4a681f09545cfafa1e77b0afce10b
Autor:
Susan D. Wilson, Kei-lai Fong, Yuu Moriya, Kathryn W. Woodburn, Paul Strzemienski, Eric Solon, Yoshihiko Tagawa, Steven Sloneker
Publikováno v:
Drug Metabolism and Disposition. 41:774-784
Peginesatide, a polyethylene glycol (PEG)ylated peptide-based erythropoiesis-stimulating agent, stimulates the erythropoietin receptor dimer that governs erythropoiesis. Studies were designed to determine the erythropoietic response, pharmacokinetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198ee90bcf74277ae962def8518577f5
https://doi.org/10.1124/dmd.112.048033
https://doi.org/10.1124/dmd.112.048033
Autor:
Susan D. Wilson, Randall J. Press, Christopher P. Holmes, Yuu Moriya, Yoshihiko Tagawa, Kei-lai Fong, Kathryn W. Woodburn
Publikováno v:
Xenobiotica; the Fate of Foreign Compounds in Biological Systems
The pharmacokinetics (PK) (absorption, distribution, metabolism, excretion) of peginesatide, a synthetic, PEGylated, investigational, peptide-based erythropoiesis-stimulating agent (ESA), was evaluated in rats. The PK profile was evaluated at 0.1-5 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25d959fcf961da24406677e35adf6ad
https://doi.org/10.3109/00498254.2011.649310
https://doi.org/10.3109/00498254.2011.649310
Autor:
Dorota Cedzik, Zhe-ming Gu, Oscar L. Laskin, Anfan Wu, Lori Capone, Sekhar Surapaneni, Peter H. Schafer, Gondi Kumar, Kei-Lai Fong, Dennis Heller, Matthew Hoffmann, Hao Feng
Publikováno v:
Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Apremilast is a novel, orally available small molecule that specifically inhibits PDE4 and thus modulates multiple pro- and anti-inflammatory mediators, and is currently under clinical development for the treatment of psoriasis and psoriatic arthriti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a12f1882b88e0997a57b9ad4adcbb73
https://doi.org/10.3109/00498254.2011.604745
https://doi.org/10.3109/00498254.2011.604745
Autor:
Thomas Ferrell, Kathryn W. Woodburn, Daniel Norton, Susan D. Wilson, Charles B. Spainhour, Kei-lai Fong, Peter J. Schatz
Publikováno v:
Haematologica. 93:1376-1379
Hematide is a synthetic peptide-based, pegylated erythropoiesis stimulating agent in clinical development for treatment of anemia. To support chronic clinical dosing requirements, a 9-month repeat dose IV monkey safety study was undertaken. Animals r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf4113bcdd105ca8e4b400b8165cd3a
https://doi.org/10.3324/haematol.12896
https://doi.org/10.3324/haematol.12896
Autor:
Thomas Ferrell, Peter J. Schatz, Kathryn W. Woodburn, Daniel Norton, Susan D. Wilson, Charles B. Spainhour, Kei-lai Fong
Publikováno v:
Drug and Chemical Toxicology. 31:229-244
The pharmacology, toxicokinetics, and safety of Hematide, a synthetic peptidic erythropoiesis-stimulating agent (ESA), were characterized. Hematide was given intravenously (0, 0.5, 5, and 50 mg/kg) weekly for five weeks with a 6- (rat) and 12-week (m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a46063482ddb8da278c523ad8cc872f
https://doi.org/10.1080/01480540701873186
https://doi.org/10.1080/01480540701873186
Autor:
Kathryn W. Woodburn, Peter J. Schatz, Sudhir A. Shah, Valentine O Wagner, Ramadevi Gudi, Susan D. Wilson, Ljubica Krsmanovic, Kei-lai Fong, Madhav Paranjpe
Publikováno v:
Drug and chemical toxicology. 34(3)
Peginesatide is a PEGylated, investigational, peptide-based erythropoiesis-stimulating agent (ESA) that was designed and engineered to stimulate specifically the erythropoietin receptor dimer that governs erythropoiesis. Clinical use of peginesatide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b7745844d6abe4cb7c3c8b6625703ad
https://pubmed.ncbi.nlm.nih.gov/21649477
https://pubmed.ncbi.nlm.nih.gov/21649477
Autor:
Kei-lai Fong, Alan M. Hoberman, Peter J. Schatz, Kathryn W. Woodburn, Elise M. Lewis, Susan D. Wilson
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology.
BACKGROUND: Aperi- and postnatal reproduction toxicity study was conducted in rats treated with Hematide, a synthetic PEGylated peptidic erythropoiesis stimulating agent (ESA). METHODS: Hematide, at IV doses of 0, 0.5, 3, and 15 mg/kg, was administer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93059147539c7e26c5aadfe0cf3f5753
https://doi.org/10.1002/bdrb.20243
https://doi.org/10.1002/bdrb.20243
Publikováno v:
Drug and chemical toxicology. 33(1)
The subchronic toxicity of Hematide™, a synthetic PEGylated peptidic erythropoiesis-stimulating agent (ESA), was evaluated in CD-1 mice at intravenous doses of 0, 1, 5, 25, and 125 mg/kg administered once every 3 weeks for 3 months. Hematide displa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb1f7a41f2d30f6ec0ba9d8cbacad09
https://pubmed.ncbi.nlm.nih.gov/19995307
https://pubmed.ncbi.nlm.nih.gov/19995307
Autor:
Woodburn, Kathryn W., Wilson, Susan D., Kei-Lai Fong, Schatz, Peter J., Spainhour, Charles B., Norton, Daniel
Publikováno v:
Basic & Clinical Pharmacology & Toxicology; Feb2009, Vol. 104 Issue 2, p155-163, 9p, 1 Chart, 6 Graphs