Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kei Taneishi"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Regulator binding and mutations alter protein dynamics. The transmission of the signal of these alterations to distant sites through protein motion results in changes in protein expression and cell function. The detection of residues involve
Externí odkaz:
https://doaj.org/article/932d74c13585440eb9ce44561746141e
Autor:
Kazutoshi Fujita, Kei Taneishi, Teruo Inamoto, Yu Ishizuya, Shingo Takada, Masao Tsujihata, Go Tanigawa, Noriko Minato, Shigeaki Nakazawa, Tsuyoshi Takada, Toshichika Iwanishi, Motohide Uemura, Yasushi Okuno, Haruhito Azuma, Nonomura Norio
Publikováno v:
BMC Urology, Vol 17, Iss 1, Pp 1-6 (2017)
Abstract Background The purposes of this study were to determine whether adjuvant chemotherapy (AC) improved the prognosis of patients with high-risk upper urinary tract urothelial carcinoma (UTUC)and to identify the patients who benefited from AC. M
Externí odkaz:
https://doaj.org/article/c8dfe0f1e706475793163d1e442a6f22
Autor:
Yu Uneno, Kei Taneishi, Masashi Kanai, Kazuya Okamoto, Yosuke Yamamoto, Akira Yoshioka, Shuji Hiramoto, Akira Nozaki, Yoshitaka Nishikawa, Daisuke Yamaguchi, Teruko Tomono, Masahiko Nakatsui, Mika Baba, Tatsuya Morita, Shigemi Matsumoto, Tomohiro Kuroda, Yasushi Okuno, Manabu Muto
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183291 (2017)
We aimed to develop an adaptable prognosis prediction model that could be applied at any time point during the treatment course for patients with cancer receiving chemotherapy, by applying time-series real-world big data.Between April 2004 and Septem
Externí odkaz:
https://doaj.org/article/d9f6fb20e126425d8c54d2662cae8d28
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports
Scientific Reports
Regulator binding and mutations alter protein dynamics. The transmission of the signal of these alterations to distant sites through protein motion results in changes in protein expression and cell function. The detection of residues involved in sign
Publikováno v:
Journal of Chemical Information and Modeling. 59:4043-4051
Dynamic allostery on proteins, triggered by regulator binding or chemical modifications, transmits information from the binding site to distant regions, dramatically altering protein function. It is accompanied by subtle changes in side-chain conform
Autor:
Kei Taneishi, Yuko Tsuchiya
Publikováno v:
Current Opinion in Structural Biology. 73:102336
An imbalance in the gut microbiome is linked to immune disorders, such as autoimmune, allergic, and chronic inflammatory disorders. Elucidation of disease mechanisms is a matter of urgency. It requires precise elucidation of the structure-based mecha
Autor:
Tasuku Honjo, Toyohiro Hirai, Yuichi Sakamori, Yasushi Okuno, Maryam Akrami, Fumihiko Matsuda, Ryusuke Hatae, Hiroaki Ozasa, Hironori Yoshida, Kazuhiro Sonomura, Kenji Chamoto, Kei Taneishi, Shuji Kawaguchi, Sidonia Fagarasan, Izuru Masuda, Young Hak Kim
Publikováno v:
JCI Insight. 5
BACKGROUND: Current clinical biomarkers for the programmed cell death 1 (PD-1) blockade therapy are insufficient because they rely only on the tumor properties, such as programmed cell death ligand 1 expression frequency and tumor mutation burden. Id
Autor:
Motohide Uemura, Yu Ishizuya, Masao Tsujihata, Nonomura Norio, Haruhito Azuma, Go Tanigawa, Toshichika Iwanishi, Noriko Minato, Kazutoshi Fujita, Yasushi Okuno, Tsuyoshi Takada, Shigeaki Nakazawa, Shingo Takada, Kei Taneishi, Teruo Inamoto
Publikováno v:
BMC Urology
BMC Urology, Vol 17, Iss 1, Pp 1-6 (2017)
BMC Urology, Vol 17, Iss 1, Pp 1-6 (2017)
Background The purposes of this study were to determine whether adjuvant chemotherapy (AC) improved the prognosis of patients with high-risk upper urinary tract urothelial carcinoma (UTUC)and to identify the patients who benefited from AC. Methods Am
Autor:
Akira Nozaki, Yasushi Okuno, Yosuke Yamamoto, Akira Yoshioka, Mika Baba, Tatsuya Morita, Shuji Hiramoto, Yoshitaka Nishikawa, Masahiko Nakatsui, Masashi Kanai, Yu Uneno, Kei Taneishi, Shigemi Matsumoto, Teruko Tomono, Kazuya Okamoto, Tomohiro Kuroda, Manabu Muto, Daisuke Yamaguchi
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183291 (2017)
PLoS ONE
PLoS ONE
Background We aimed to develop an adaptable prognosis prediction model that could be applied at any time point during the treatment course for patients with cancer receiving chemotherapy, by applying time-series real-world big data. Methods Between A
Publikováno v:
Natural Computing. 12:589-603
In de novo drug design, chemical compounds are quantitized as real-valued vectors called chemical descriptors, and an optimization algorithm runs on known drug-like chemical compounds in a database and outputs an optimal chemical descriptor. Since st