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Akademický článek

Determining the Relationship between Mechanical Properties and Quantitative Magnetic Resonance Imaging of Joint Soft Tissues Using Patient-Specific Templates

Autor: Takehito Hananouchi, Shinji Satake, Kei Sakao, Hiroshi Katsuda, Nagakazu Shimada, Erik W. Dorthe, Darryl D. D’Lima

Publikováno v: Bioengineering, Vol 10, Iss 9, p 1050 (2023)

To determine whether the mechanical properties of joint soft tissues such as cartilage can be calculated from quantitative magnetic resonance imaging (MRI) data, we investigated whether the mechanical properties of articular cartilage and meniscus sc

Externí odkaz: https://doaj.org/article/92b4530cadb14425b606208a5bac90cf

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Intra-articular injection of hyaluronan restores the aberrant expression of matrix metalloproteinase-13 in osteoarthritic subchondral bone

Autor: Toshikazu Kubo, Osam Mazda, Kuniaki Honjo, Nobuyuki Hiraoka, Kei Sakao, Yuji Arai, Kenji Takahashi, Sakae Tanaka, Tsunao Kishida

Publikováno v: Journal of Orthopaedic Research. 29:354-360

Subchondral bone is a candidate for treatment of osteoarthritis (OA). We investigated the effects of intra-articular injection of hyaluronan (IAI-HA) on subchondral bone in rabbit OA model. OA was induced by anterior cruciate ligament transection, wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::632fe176d7ab40221d03ece17f8b12f4
https://doi.org/10.1002/jor.21240

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Influence of extracellular matrix on the expression of inflammatory cytokines, proteases, and apoptosis-related genes induced by hydrostatic pressure in three-dimensionally cultured chondrocytes

Autor: Toru Morihara, Atsuo Inoue, Yuji Arai, Hitoshi Tonomura, Toshikazu Kubo, Kei Sakao, Osam Mazda, Taisuke Kunitomo, Kenji Takahashi, Jiro Imanishi, Masazumi Saito, Kuniaki Honjo

Publikováno v: Journal of Orthopaedic Science. 14:776-783

The purpose of this study was to investigate the influence of hydrostatic pressure (HP) on the gene expression of cartilage matrix, cytokines, and apoptosis-associated factors in chondrocytes in which the cartilage was in extracellular matrix (ECM)-r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e5d56a1b1a704a831f92603fcabfe5
https://doi.org/10.1007/s00776-009-1393-0

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Asporin and transforming growth factor-β gene expression in osteoblasts from subchondral bone and osteophytes in osteoarthritis

Autor: Osam Mazda, Nobuyuki Hiraoka, Toshikazu Kubo, Masazumi Saito, Kuniaki Honjyo, Kenji Takahashi, Kei Sakao, Yuji Arai, Jiro Imanishi, Tsunao Kishida

Publikováno v: Journal of Orthopaedic Science. 14:738-747

To clarify the significance of subchondral bone and osteophytes in the pathology of osteoarthritis (OA), we investigated the expression of asporin (ASPN), transforming growth factor-beta1 (TGF-beta1), TGF-beta2, TGF-beta3, and runt-related transcript

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0760ba0696cdc2b269086189da0dbdc7
https://doi.org/10.1007/s00776-009-1401-4

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N -acetylcysteine prevents nitric oxide-induced chondrocyte apoptosis and cartilage degeneration in an experimental model of osteoarthritis

Autor: Kuniaki Honjo, Osam Mazda, Shuji Nakagawa, Tsunao Kishida, Kenji Takahashi, Yuji Arai, Jiro Imanishi, Kei Sakao, Toshikazu Kubo, Masazumi Saito

Publikováno v: Journal of Orthopaedic Research. 28:156-163

We investigated whether N-acetylcysteine (NAC), a precursor of glutathione, could protect rabbit articular chondrocytes against nitric oxide (NO)-induced apoptosis and could prevent cartilage destruction in an experimental model of osteoarthritis (OA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fad1c03793f5482c7f926ca855b1837e
https://doi.org/10.1002/jor.20976

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Comparison of anti-rheumatic effects of local RNAi-based therapy in collagen induced arthritis rats using various cytokine genes as molecular targets

Autor: Masazumi Saito, Kenji Takahashi, Masaharu Shin-Ya, Tsunao Kishida, Hitoshi Tonomura, Kei Sakao, Jiro Imanishi, Toshikazu Kubo, Yuji Arai, Osam Mazda, Toru Morihara, Atsuo Inoue

Publikováno v: Modern Rheumatology. 19:125-133

RNA interference (RNAi) provides a powerful means of sequence-specific gene silencing. Several studies show that RNAi may provide promising strategies to treat human diseases by suppressing disease responsible genes in vivo. In locomotor diseases, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88315ca3992a32b5f121ca8eb76ff1bf
https://doi.org/10.3109/s10165-008-0131-3

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Enhanced expression of interleukin-6, matrix metalloproteinase-13, and receptor activator of NF-κB ligand in cells derived from osteoarthritic subchondral bone

Autor: Kei Sakao, Osam Mazda, Masazumi Saito, Toshikazu Kubo, Yuji Arai, Jiro Imanishi, Hisatake Takamiya, Mikihiro Fujioka, Kenji Takahashi, Hitoshi Tonomura, Atsuo Inoue

Publikováno v: Journal of Orthopaedic Science. 13:202-210

The aim of this study was to clarify the significance of subchondral bone in the pathology of osteoarthritis (OA) by investigating the expression of inflammatory cytokines, proteases, and receptor activator of NF-kappaB ligand (RANKL)/receptor activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d6884b9e993ff856a44f41ca1af6a49
https://doi.org/10.1007/s00776-008-1227-5

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Hydrostatic Pressure Induces Cytokine Production in Human Periodontal Ligament Cells

Autor: Toshikazu Kubo, Toshiro Yamamoto, Narisato Kanamura, Kenji Takahashi, Takeshi Amemiya, Fumishige Oseko, Masakazu Kita, Kei Sakao, Isao Kimura, Akira Nakanishi

Publikováno v: Oral Science International. 3:64-71

Periodontal tissue has a unique structure in that the human periodontal ligament (hPDL) lies between the hard tissues of cementum and alveolar bone. Although the role of cytokines in hPDL function is not clearly understood, we investigated the effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617b5a007e1f477eb092eb026ff4b5f9
https://doi.org/10.1016/s1348-8643(06)80003-0

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N-acetylcysteine prevents nitric oxide-induced chondrocyte apoptosis and cartilage degeneration in an experimental model of osteoarthritis

Autor: Shuji, Nakagawa, Yuji, Arai, Osam, Mazda, Tsunao, Kishida, Kenji A, Takahashi, Kei, Sakao, Masazumi, Saito, Kuniaki, Honjo, Jiro, Imanishi, Toshikazu, Kubo

Publikováno v: Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 28(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26da7845ad2b3a7818fba61602daae80
https://pubmed.ncbi.nlm.nih.gov/19725096

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Osteoblasts derived from osteophytes produce interleukin-6, interleukin-8, and matrix metalloproteinase-13 in osteoarthritis

Autor: Kenji Takahashi, Masazumi Saito, Yuji Arai, Kei Sakao, Hidetsugu Asada, Kuniaki Honjo, Osam Mazda, Jiro Imanishi, Toshikazu Kubo, Masaharu Shin-Ya, Nobuyuki Hiraoka

Publikováno v: Journal of bone and mineral metabolism. 27(4)

To clarify the significance of the osteophytes that appear during the progression of osteoarthritis (OA), we investigated the expression of inflammatory cytokines and proteases in osteoblasts from osteophytes. We also examined the influence of mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b16dd2089d8deb1f5448677ce96503
https://pubmed.ncbi.nlm.nih.gov/19333684

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