Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Kei Okatsu"'
Autor:
Erika Tsutsumi, Satomi Niwa, Ryota Takeda, Natsuki Sakamoto, Kei Okatsu, Shuya Fukai, Hideo Ago, Satoshi Nagao, Hiroshi Sekiguchi, Kazuki Takeda
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract Iron-sulfur clusters are prosthetic groups of proteins involved in various biological processes. However, details of the immature state of the iron-sulfur cluster into proteins have not yet been elucidated. We report here the first structura
Externí odkaz:
https://doaj.org/article/30b12ec1b8914a4389fcc2ab513e3b95
Autor:
Yusuke Sato, Hikaru Tsuchiya, Atsushi Yamagata, Kei Okatsu, Keiji Tanaka, Yasushi Saeki, Shuya Fukai
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The Lys48-linked polyubiquitin-mediated proteasomal degradation in yeast depends on Cdc48 and its cofactors Ufd1 and Npl4. Here, the authors present crystal structures of Npl4 bound to Lys48-linked diubiquitin and the Npl4-binding motif of Ufd1, prov
Externí odkaz:
https://doaj.org/article/4244723ac5d244baa41f569db4a6c956
Autor:
Norihiko Yokoi, Yuko Fukata, Kei Okatsu, Atsushi Yamagata, Yan Liu, Makoto Sanbo, Yuri Miyazaki, Teppei Goto, Manabu Abe, Hidetoshi Kassai, Kenji Sakimura, Dies Meijer, Masumi Hirabayashi, Shuya Fukai, Masaki Fukata
Publikováno v:
Cell Reports, Vol 37, Iss 11, Pp 110107- (2021)
Summary: What percentage of the protein function is required to prevent disease symptoms is a fundamental question in genetic disorders. Decreased transsynaptic LGI1-ADAM22 protein complexes, because of their mutations or autoantibodies, cause epilep
Externí odkaz:
https://doaj.org/article/5da5384129fc4484b4ce507f1ce2786f
Autor:
Kei OKATSU
Publikováno v:
Nihon Kessho Gakkaishi. 63:259-260
Autor:
Atsushi Yamagata, Hikaru Tsuchiya, Kei Okatsu, Yasushi Saeki, Yusuke Sato, Keiji Tanaka, Shuya Fukai
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Npl4 is likely to be the most upstream factor recognizing Lys48-linked polyubiquitylated substrates in the proteasomal degradation pathway in yeast. Along with Ufd1, Npl4 forms a heterodimer (UN), and functions as a cofactor for the Cdc48 ATPase. Her
Autor:
Yasushi Saeki, Keiji Tanaka, Minoru Ishikawa, Sakurako Goto-Ito, Noriyuki Matsuda, Atsushi Yamagata, Yusuke Sato, Koji Yamano, Shuya Fukai, Kei Okatsu, Ai Kaiho, Yuichi Hashimoto
Publikováno v:
Nature Structural & Molecular Biology. 24:911-919
Parkin ubiquitin (Ub) ligase (also known as PARK2) ubiquitinates damaged mitochondria for their clearance and quality control. USP30 deubiquitinase opposes parkin-mediated Ub-chain formation on mitochondria by preferentially cleaving Lys6-linked Ub c
Autor:
Yuki Kujuro, Queliconi Bruno, Waka Kojima, Kei Okatsu, Noriyuki Matsuda, Mayumi Kimura, Koji Yamano, Fumika Koyano, Keiji Tanaka
Publikováno v:
Genes to Cells. 21:772-788
DJ-1 has been identified as a gene responsible for recessive familial Parkinson's disease (familial Parkinsonism), which is caused by a mutation in the PARK7 locus. Consistent with the inferred correlation between Parkinson's disease and mitochondria
Autor:
Yutaka Ito, Noriyuki Matsuda, Kei Okatsu, Yusuke Sato, Atsushi Yamagata, Toshihiko Oka, Masaki Mishima, Lumi Negishi, Keiji Tanaka, Koji Yamano, Shuya Fukai, Akiko Takahashi, Sakurako Goto-Ito
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Mutations of PTEN-induced putative kinase 1 (PINK1) and the E3 ubiquitin (Ub) ligase parkin can cause familial parkinsonism. These two proteins are essential for ubiquitylation of damaged mitochondria and subsequent degradation. PINK1 phosphorylates
Autor:
Seiji Hori, Akira Kakizuka, Kei Okatsu, Junko Kawawaki, Yukie Kakiyama, Noriyuki Matsuda, Junpei Fukushi, Yoko Kimura, Keiji Tanaka
Publikováno v:
Genes to Cells. 18:1131-1143
VCP/p97 is a hexameric ring-shaped AAA(+) ATPase that participates in various ubiquitin-associated cellular functions. Mis-sense mutations in VCP gene are associated with the pathogenesis of two inherited diseases: inclusion body myopathy associated
Autor:
Mayumi Kimura, Kei Okatsu, Shinsuke Ishigaki, Gen Sobue, Noriyuki Matsuda, Fumika Koyano, Keiji Tanaka, Yusuke Fujioka
Publikováno v:
Genes to Cells
PINK1 and PARKIN are causal genes for hereditary Parkinsonism. Recent studies have shown that PINK1 and Parkin play a pivotal role in the quality control of mitochondria, and dysfunction of either protein likely results in the accumulation of low-qua